Data Sheet 2_PitNET tissue deconvolution: tracing normal tissue residues and immune dynamics.pdf by Mattia Dalle Nogare (22696022)

“…However, its limited ability to resolve cellular heterogeneity – particularly in samples containing residual non-tumor pituitary cells – remains a significant challenge.</p>Objective<p>We developed and validated a tissue deconvolution framework using a reference dataset derived from single-nucleus RNA sequencing (snRNA-seq) of normal pituitary tissue, aimed at estimating cellular composition in PitNETs from bulk RNA-seq data and characterizing the tumor microenvironment (TME).…”

Table 1_GLP-1 and glucagon receptor dual agonism ameliorates kidney allograft fibrosis by improving lipid metabolism.docx by Linjie Peng (12553717)

“…Pathological analysis demonstrated that TB001 treatment reduced inflammatory cell infiltration and downregulated the expression of fibrosis markers, including TGF-β1, α-SMA, COL1A1, and Vimentin. Further transcriptome sequencing of kidney grafts revealed that TB001-treated group had a gene expression pattern similar to that of the syngeneic control group and showed significant enhancement of lipid metabolism-related pathways, particularly the PPAR pathway. …”

Table 2_PitNET tissue deconvolution: tracing normal tissue residues and immune dynamics.xlsx by Mattia Dalle Nogare (22696022)

“…However, its limited ability to resolve cellular heterogeneity – particularly in samples containing residual non-tumor pituitary cells – remains a significant challenge.</p>Objective<p>We developed and validated a tissue deconvolution framework using a reference dataset derived from single-nucleus RNA sequencing (snRNA-seq) of normal pituitary tissue, aimed at estimating cellular composition in PitNETs from bulk RNA-seq data and characterizing the tumor microenvironment (TME).…”

Table 1_Safety and efficacy of canine recombinant IL-15 in mammary gland tumors.docx by Min-Hee Kang (811734)

“…Sixty-one client-owned dogs were initially enrolled, and 55 completed the 12-week study. Dogs were assigned to a test group receiving rcIL-15 with surgery or a control group undergoing surgery alone. …”

Hesperetin attenuates ischemia/reperfusion-induced acute kidney injury by regulating ferroptosis in mice by Xiaoyu Xie (2568607)

“…Ferroptosis markers showed that hesperetin decreased levels of ACSL4 while increasing GPX4, FTH1, and SLC7A11, suggesting an anti-ferroptotic effect. …”

Table 1_Proteomic profiling of peripheral blood mononuclear cells reveals immune dysregulation and metabolic alterations in kidney transplant recipients with COVID-19.docx by Giuseppe G. F. Leite (18186056)

“…<p>The COVID-19 pandemic has significantly impacted global health, especially in vulnerable populations like kidney transplant recipients (KTRs). …”

Table 1_PitNET tissue deconvolution: tracing normal tissue residues and immune dynamics.xlsx by Mattia Dalle Nogare (22696022)

“…However, its limited ability to resolve cellular heterogeneity – particularly in samples containing residual non-tumor pituitary cells – remains a significant challenge.</p>Objective<p>We developed and validated a tissue deconvolution framework using a reference dataset derived from single-nucleus RNA sequencing (snRNA-seq) of normal pituitary tissue, aimed at estimating cellular composition in PitNETs from bulk RNA-seq data and characterizing the tumor microenvironment (TME).…”

Table 1_Evolving landscape of female cancers along with attributable risk factors in China from 1990 to 2021, and projections to 2040.xlsx by Yali Han (4676677)

“…Background<p>Female cancers pose a significant health burden in China, and this study identified and projected epidemiological trends of these cancers.…”

Table 1_Intergenerational education mobility in India: nonlinearity and the Great Gatsby Curve.docx by P. K. V. Kishan (19744606)

“…</p>Results<p>Our analysis reveals a high degree of intergenerational persistence in education, although this persistence has decreased over time. …”

Data Sheet 1_Danqi soft caspule alleviates myocardial ischemia-reperfusion injury induced cardiomyocyte apoptosis by attenuating mitochondrial fission.docx by Ye Yang (297214)

“…Background<p>Myocardial ischemia-reperfusion (I/R) injury which leads to continuously worsening ventricular remodeling and cardiac dysfunction in the chronic stage, is a significant contributor to the global prevalence of heart failure. …”

Data_Sheet_1_Effects of stand age and soil microbial communities on soil respiration throughout the growth cycle of poplar plantations in northeastern China.pdf by Xiangrong Liu (380124)

“…As stand age increased, Rs showed a significant decreasing trend. We further identified r-selected microbial communities (copiotrophic species) as key biological factors influencing the decline in Rs with increasing stand age. …”

Table 3_Proteomic profiling of peripheral blood mononuclear cells reveals immune dysregulation and metabolic alterations in kidney transplant recipients with COVID-19.xlsx by Giuseppe G. F. Leite (18186056)

“…<p>The COVID-19 pandemic has significantly impacted global health, especially in vulnerable populations like kidney transplant recipients (KTRs). …”

Image_2_Cytomegalovirus results in poor graft function via bone marrow-derived endothelial progenitor cells.PNG by Weiran Lv (715679)

“…Introduction<p>Poor graft function (PGF), characterized by myelosuppression, represents a significant challenge following allogeneic hematopoietic stem cell transplantation (allo-HSCT) with human cytomegalovirus (HCMV) being established as a risk factor for PGF. …”

Data Sheet 1_GLP-1 and glucagon receptor dual agonism ameliorates kidney allograft fibrosis by improving lipid metabolism.pdf by Linjie Peng (12553717)

“…Pathological analysis demonstrated that TB001 treatment reduced inflammatory cell infiltration and downregulated the expression of fibrosis markers, including TGF-β1, α-SMA, COL1A1, and Vimentin. Further transcriptome sequencing of kidney grafts revealed that TB001-treated group had a gene expression pattern similar to that of the syngeneic control group and showed significant enhancement of lipid metabolism-related pathways, particularly the PPAR pathway. …”

DataSheet1_Engineered myeloid precursors differentiate into osteoclasts and resorb heterotopic ossification in mice.docx by Cameron Rementer (20310858)

“…Once symptomatic, HO causes pain, limited mobility and decreased quality of life. Current treatments are limited and have significant complications with high recurrence rates, underscoring the need for improved therapeutic interventions. …”

Data Sheet 1_Evolving landscape of female cancers along with attributable risk factors in China from 1990 to 2021, and projections to 2040.pdf by Yali Han (4676677)

“…Background<p>Female cancers pose a significant health burden in China, and this study identified and projected epidemiological trends of these cancers.…”

Data Sheet 1_Genome-wide development of SSR molecular markers for modern sugarcane cultivars.docx by Yi Xu (131145)

“…In this study, We searched for and identified SSR loci within the genomes of 14 Poaceae plants. Notably, a significant positive correlation (r = 0.958) was detected between genome size and the number of SSRs. …”

Table 1_Global, regional, and national burden of cardiovascular disease attributable to high body mass index from 1990 to 2021 and projection to 2045.docx by Hui Li (32376)

“…Over the study period, the overall CVD burden attributable to HBMI decreased significantly, while the burden of atrial fibrillation and flutter increased. …”

Image 3_Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response.tif by Jorgo Lika (21189020)

“…Treatment with these inhibitors also impacts neutrophil redox status, migration, and apoptosis without significantly changing overall bioenergetics.</p>Conclusions<p>Together, these results demonstrate that mitochondrial metabolism is dynamically remodeled and plays a significant role in neutrophils. …”

Supplementary Materials - Figure by Shaojie Zhang (20807333)

“…<p dir="ltr">Exposure to hypobaric hypoxia during rapid ascent to high altitudes significantly impacts intestinal barrier function. Goblet cells, as one of the primary cell types in the intestinal mucosa, play a crucial role in maintaining this barrier. …”