Data Sheet 5_Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.xlsx حسب Shengyou Song (22391068)

"…In vivo, lathyrol suppressed the mRNA and protein expression of TGF-β1, TGF-βR1, Smad2, Smad3, Smad4, and Smad9 in RCC xenografts; promoted the protein expression of Smad6; and decreased the protein expression of cyclin D1, cyclin B1, cyclin A1, cyclin E1, CDK6, CDK4, and CDK1 while increasing the expression of P16, P21, and P27.…"

Supplementary file 1_Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.pdf حسب Shengyou Song (22391068)

"…In vivo, lathyrol suppressed the mRNA and protein expression of TGF-β1, TGF-βR1, Smad2, Smad3, Smad4, and Smad9 in RCC xenografts; promoted the protein expression of Smad6; and decreased the protein expression of cyclin D1, cyclin B1, cyclin A1, cyclin E1, CDK6, CDK4, and CDK1 while increasing the expression of P16, P21, and P27.…"

Supplementary file 2_Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.pdf حسب Shengyou Song (22391068)

"…In vivo, lathyrol suppressed the mRNA and protein expression of TGF-β1, TGF-βR1, Smad2, Smad3, Smad4, and Smad9 in RCC xenografts; promoted the protein expression of Smad6; and decreased the protein expression of cyclin D1, cyclin B1, cyclin A1, cyclin E1, CDK6, CDK4, and CDK1 while increasing the expression of P16, P21, and P27.…"

Data Sheet 9_Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.xlsx حسب Shengyou Song (22391068)

"…In vivo, lathyrol suppressed the mRNA and protein expression of TGF-β1, TGF-βR1, Smad2, Smad3, Smad4, and Smad9 in RCC xenografts; promoted the protein expression of Smad6; and decreased the protein expression of cyclin D1, cyclin B1, cyclin A1, cyclin E1, CDK6, CDK4, and CDK1 while increasing the expression of P16, P21, and P27.…"

Data Sheet 6_Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.xlsx حسب Shengyou Song (22391068)

"…In vivo, lathyrol suppressed the mRNA and protein expression of TGF-β1, TGF-βR1, Smad2, Smad3, Smad4, and Smad9 in RCC xenografts; promoted the protein expression of Smad6; and decreased the protein expression of cyclin D1, cyclin B1, cyclin A1, cyclin E1, CDK6, CDK4, and CDK1 while increasing the expression of P16, P21, and P27.…"

Data Sheet 8_Lathyrol inhibits the proliferation of Renca cells by altering expression of TGF-β/Smad pathway components and subsequently affecting the cell cycle.xlsx حسب Shengyou Song (22391068)

"…In vivo, lathyrol suppressed the mRNA and protein expression of TGF-β1, TGF-βR1, Smad2, Smad3, Smad4, and Smad9 in RCC xenografts; promoted the protein expression of Smad6; and decreased the protein expression of cyclin D1, cyclin B1, cyclin A1, cyclin E1, CDK6, CDK4, and CDK1 while increasing the expression of P16, P21, and P27.…"

Data Sheet 1_Transcriptome analysis of historic olives reveals stress-specific biomarkers.docx حسب Hamad A. Alkhatatbeh (21488114)

"…Introduction<p>Water scarcity and soil salinization are increasingly becoming limiting factors in food production, including olives, a major fruit crop in several parts of the world. …"

Data Sheet 1_Global burden, trends and inequalities of maternal hypertensive disorders among reproductive-age women of advanced maternal age, 1990–2021: a population-based study.pd... حسب Xuanyu Zhao (5881895)

"…</p>Conclusion<p>Despite overall declines in MHD burden, significant disparities persist, particularly in low SDI regions. …"

Quantifying bactericidal effects of cold Ar-CAPP against diverse <i>E. coli</i> strains. حسب Elanie F. Briggs (22103678)

"…<p><b>(A)</b> Increasing the gas flow rate and time durations of exposure of cells yields more killing by cold Ar-CAPP when applying 6 kV. …"

Modulation of renal inflammation and tubular injury by calcitriol in patients with early diabetic kidney disease: a randomized controlled trial حسب Pringgodigdo Nugroho (15460802)

"…Although UACR decreased more in the calcitriol group, the difference was not statistically significant (<i>p</i> = 0.099). …"

Supplementary file 3_The interventional effect of astragaloside IV on rodent models of myocardial fibrosis: a systematic review and meta-analysis.doc حسب Haozhe Li (6399116)

"…The findings indicated that AS-IV led to a reduction in morphostructural indices, including CVF, LVESd, LVEDd, IVSd, LVPWd, and LVMI. Moreover, it decreased LVEDp and LVSP, while increasing hemodynamic indices such as LVEF, LVFS, +dp/dtmax, and −dp/dtmax. …"

Supplementary file 1_The interventional effect of astragaloside IV on rodent models of myocardial fibrosis: a systematic review and meta-analysis.doc حسب Haozhe Li (6399116)

"…The findings indicated that AS-IV led to a reduction in morphostructural indices, including CVF, LVESd, LVEDd, IVSd, LVPWd, and LVMI. Moreover, it decreased LVEDp and LVSP, while increasing hemodynamic indices such as LVEF, LVFS, +dp/dtmax, and −dp/dtmax. …"

Supplementary file 2_The interventional effect of astragaloside IV on rodent models of myocardial fibrosis: a systematic review and meta-analysis.doc حسب Haozhe Li (6399116)

"…The findings indicated that AS-IV led to a reduction in morphostructural indices, including CVF, LVESd, LVEDd, IVSd, LVPWd, and LVMI. Moreover, it decreased LVEDp and LVSP, while increasing hemodynamic indices such as LVEF, LVFS, +dp/dtmax, and −dp/dtmax. …"

Age-related driver injury occurrence from crashes at curve–grade combined segments حسب Hellen Shita (19746166)

"…</p> <p>The results emphasize the significance of tailored education and outreach countermeasures, particularly for teen and older drivers, aimed at decreasing the likelihood of injuries in such driving environments. …"

DataSheet1_IVIG response in pediatric acute-onset neuropsychiatric syndrome correlates with reduction in pro-inflammatory monocytes and neuropsychiatric measures.docx حسب Isaac Melamed (6291590)

"…The fraction of pro-inflammatory monocytes and dendritic cells decreased from pre-IVIG treatment levels. The proportional reductions were not compensated by increases in total white blood cells; pro-inflammatory monocytes post-IVIG were decreased as a proportion of CD14+ myeloid cells and in absolute number.…"

Table 1_Trend analysis of pediatric urolithiasis prevalence from 1990 to 2021 in the BRICS.docx حسب Zhi-gang Zhang (328212)

"…</p>Result<p>Globally, the prevalence has been increasing every year, with the greatest increase in the 10–14 age group. …"

Data Sheet 1_A dual inhibitor of TrxR1 and XIAP induces pyroptosis in melanoma.docx حسب Yuan Wang (14955)

"…Mechanistically, TRI-03 not only increases intracellular reactive oxygen species (ROS) levels by inhibiting TrxR1 activity but also decreases XIAP expression, leading to the activation of the caspase-9/caspase-3/GSDME axis and irreversible GSDME-mediated pyroptosis in melanoma cells. …"

Studying Responses of Drosophila Brain After Laser Induced ShockWave Damage حسب Sonia Kang (22347570)

"…NucBlue intensity decreased near the laser focus point, indicating localized impact.…"

Table 2_Drug-induced urinary retention: a real-world pharmacovigilance study using FDA and Canada vigilance databases.xlsx حسب Xianyu Dai (18939514)

"…The median age among these cases was 65 years, with males comprising 53.4%. There were significant annual increases in UR reports associated with antineoplastic agents (0.19% per year) and antidiabetic drugs (0.09% per year), while reports linked to bronchodilators decreased (−0.53% per year). …"

Table 1_Drug-induced urinary retention: a real-world pharmacovigilance study using FDA and Canada vigilance databases.docx حسب Xianyu Dai (18939514)

"…The median age among these cases was 65 years, with males comprising 53.4%. There were significant annual increases in UR reports associated with antineoplastic agents (0.19% per year) and antidiabetic drugs (0.09% per year), while reports linked to bronchodilators decreased (−0.53% per year). …"