Supplementary file 1_Comprehensive real-time metabolic profiling of peripheral blood mononuclear cells reveals important methodological considerations for immunometabolism research... by Michael Macleod (22516823)

“…Extended blood processing time significantly lowered T cell activation capacity in PBMCs, evidenced by decreased responses of mitochondrial and glycolytic ATP supply to CD3/CD28 activation.…”

<b>Seasonal Hydrology and Projected Landscape Changes Jointly Shape Future Water Quality in a Typical Watershed of the Three Gorges Reservoir Area</b> by Xiaojun Zhao (22390147)

“…Under future scenarios of aggravated landscape fragmentation, TN concentrations decreased while TOC and COD_Mn concentrations significantly increased compared to the 2024 dry season. …”

Image 4_SarZ inhibits the hemolytic activity through regulation of phenol soluble modulins in Staphylococcus epidermidis.jpeg by Xiao Chen (260187)

“…The sarZ psmβ double mutant was further generated and displayed a significantly decreased hemolytic activity compared with the sarZ mutant. …”

Table1_Cover crops lower the dispersal of grapevine foliar pathogens from the ground and contribute to early-season disease management.docx by Gultekin Hasanaliyeva (17752296)

“…This study explored the possibility of decreasing the use of fungicides to control these diseases using cover crops in the inter-row of vineyards. …”

Data Sheet 1_Integrative analysis of transcriptome and metabolome reveals molecular mechanisms of dynamic change of storage substances during dehydration and drying process in pean... by Jingjing Deng (468275)

“…S3d was the key period during which the content of most of the metabolites changed significantly. The contents of most amino acids(87%) and their derivatives decreased significantly, and most of the lipids(68%), sugars(67%) and flavonoids(87%) accumulated to their peak at S3d. …”

Data Sheet 1_Potential cerebrospinal fluid metabolomic biomarkers and early prediction model for Parkinson’s disease.docx by Yifan Zhang (119570)

“…</p>Results<p>Sixty-four metabolites were significantly altered in PD patients compared to HC, with 58 elevated and 6 reduced. …”

Short-term antiretroviral therapy may not correct the dysregulations of plasma virome and cytokines induced by HIV-1 infection by Yingying Ma (3617810)

“…These results suggest that short-term ART may not significantly correct the virome and cytokine dysregulations induced by HIV-1 infection. …”

Data Sheet 1_Lysate of Parabacteroides distasonis prevents severe forms of experimental autoimmune encephalomyelitis by modulating the priming of T cell response.docx by Zuzana Jiraskova Zakostelska (6386825)

“…EAE induction was the main factor in altering the gut microbiota, decreasing the abundance of lactobacilli and segmented filamentous bacteria. …”

Supplementary Material for: Using smartphone data to frequently measure atopic dermatitis severity and understand triggers: A decentralized 12-week observational study by Ali Z. (5634332)

“…Decreasing temperature was significantly associated with higher POEM (estimate -0.18, p=0.012) and EASI score (estimate -0.14, p=0.007), but not with SCORAD. …”

Supplementary Material for: Hypothyroidism promotes microglia M1 polarization by inhibiting BDNF-promoted PI3K-Akt signaling pathway by Zhan Y. (4157410)

“…In BV2 cells, LPS treatment decreased expression of BDNF, IL-10, and Arg1, while BDNF overexpression (BDNF-OE) significantly reversed the inflammation-induced by LPS by repressing iNOS and TNF-α, while increasing IL-10 and Arg1. …”

Molecular features influencing clinical outcome of advanced HER2-positive gastric cancer receiving trastuzumab plus chemotherapy by Yu Lei (266919)

“…Additionally, after treatment, TMB significantly increased in non-responders, while CIN significantly decreased in responders.…”

Data Sheet 1_Investigating the underlying mechanisms of the ethanol extract of saussureae involucratae herba in anti-rheumatoid arthritis effect based on sphingolipidomics.pdf by Pingyuan Chi (21563069)

“…In cell assays, SIE significantly decreased the protein levels of TNF-α and IL-6 (both P < 0.01) in LPS-stimulated RAW 264.7 cells. …”

Supplementary Material for: Protein inhibitor of activated STAT 2 (PIAS2) protects against podocyte injury in diabetic nephropathy via inhibiting JAK2/STAT3 pathway by figshare admin karger (2628495)

“…Overexpression of PIAS2 significantly reversed high glucose-induced human podocytes injury, evidenced by increased cell viability, reduced cell apoptosis, decreased expression of pro-apoptotic proteins Bax and cleaved-Caspase3, increased expression of the anti-apoptotic protein Bcl-2, and reduced secretion of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. …”

Table 1_The relationship between positive future thinking, entrapment, defeat and death-related mental imagery in individuals with and without a suicidal history: an experimental s... by Gonca Köse (21477470)

“…Mean scores for PFT from pre-to post-negative mood induction decreased significantly in the participants with a history of suicidal thoughts/behaviours but not in those without a suicidal history. …”

Data Sheet 1_Stand structure influences understory plant diversity through soil factors: three afforestation types of Masson’s pine in the upper Yangtze River, China.docx by Yongqi Xiang (12548293)

“…In terms of stand structure, MCLMF significantly increased the opening degree (O), mingling index (M), and competition index (CI), while MLMF decreased CI but increased M. …”

Table1_The role of SIRT1-FXR signaling pathway in valproic acid induced liver injury: a quantitative targeted metabolomic evaluation in epileptic children.DOCX by Mingming Zhao (760369)

“…Only three bile acid metabolites, taurodeoxycholic acid, taurochenodeoxycholic acid, and deoxycholic acid, were significantly different between the ANLF1 and ANLF2 groups, increasing at first and then decreasing with the aggravation of liver injury. …”

Proteomic analysis for busulfan-induced spermatogenesis disorder by Ke Hu (84619)

“…Western blotting revealed that LDHAL6B protein significantly increased at 10 days, decreased from 20 to 60 days, and then gradually elevated from 70 to 80 days after busulfan treatment.…”

<b>The Impact of Vitiligo on Pregnancy and Perinatal Outcome: A Systematic Review and Meta-analysis</b> by Lilia Maria Lima de Oliveira (21864683)

“…Pregnant women with vitiligo had a significantly higher chance of spontaneous abortion (OR 1.26; 95% CI [1.17, 1.36]), but a significantly lower chance of cesarean delivery (OR 0.93; 95% CI [0.87, 0.99]) than pregnant women without vitiligo. …”

Data Sheet 1_Baicalein ameliorates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and regulating gut microbiota.docx by Weiguang Lv (8622405)

“…After baicalein treatment, the proinflammatory cytokines (TNF-α, IL-1β), and anti-inflammatory cytokine (IL-10) has decreased. Additionally, high-dose of baicalein strongly reversed oxidative stress alterations caused by DSS, as evidenced by Fe²⁺, MDA, ROS significantly depleted, and MPO, SOD, GSH significantly increased. …”

Quantitative real-time PCR primer sequences. by Lydie M. O. Barbeau (5941712)

“…<div><p>In the last decade, advancements in understanding the genetic landscape of lung squamous cell carcinoma (LUSC) have significantly impacted therapy development. Immune checkpoint inhibitors (ICI) have shown great promise, improving overall and progression-free survival in approximately 25% of the patients. …”