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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
role decrease » rate decreased (Expand Search), road decreased (Expand Search), note decreased (Expand Search)
fold decrease » fold increase (Expand Search), fold increased (Expand Search), fold increases (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
role decrease » rate decreased (Expand Search), road decreased (Expand Search), note decreased (Expand Search)
fold decrease » fold increase (Expand Search), fold increased (Expand Search), fold increases (Expand Search)
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Advantages of Novel Anti-cancer Selenosemicarbazones: Preferential Reactivity of Their Fe(III), Cu(II), and Zn(II) Complexes with Key Physiological Reductants/Ligands Versus Isoste...
Published 2025“…Considering this: (1) [Fe(PPP4pSe)<sub>2</sub>]<sup>+</sup> demonstrated increased reduction relative to [Fe(PPP4pT)<sub>2</sub>]<sup>+</sup> with glutathione and l-cysteine, while l-ascorbate led to comparable reduction; (2) glutathione led to complete dissociation of [Zn(PPP4pSe)<sub>2</sub>], while incomplete dissociation of [Zn(PPP4pT)<sub>2</sub>] occurred; and (3) [Cu(PPP4pSe)Cl] demonstrated complete coordinate sphere substitution with glutathione, l-cysteine, and l-ascorbate, whereas [Cu(PPP4pT)Cl] demonstrated partial substitution. The role of glutathione in all three latter reactions is significant, given the greater reactivity of the selenosemicarbazone, and glutathione’s key role in selenosemicarbazone and thiosemicarbazone anticancer activity.…”
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Advantages of Novel Anti-cancer Selenosemicarbazones: Preferential Reactivity of Their Fe(III), Cu(II), and Zn(II) Complexes with Key Physiological Reductants/Ligands Versus Isoste...
Published 2025“…Considering this: (1) [Fe(PPP4pSe)<sub>2</sub>]<sup>+</sup> demonstrated increased reduction relative to [Fe(PPP4pT)<sub>2</sub>]<sup>+</sup> with glutathione and l-cysteine, while l-ascorbate led to comparable reduction; (2) glutathione led to complete dissociation of [Zn(PPP4pSe)<sub>2</sub>], while incomplete dissociation of [Zn(PPP4pT)<sub>2</sub>] occurred; and (3) [Cu(PPP4pSe)Cl] demonstrated complete coordinate sphere substitution with glutathione, l-cysteine, and l-ascorbate, whereas [Cu(PPP4pT)Cl] demonstrated partial substitution. The role of glutathione in all three latter reactions is significant, given the greater reactivity of the selenosemicarbazone, and glutathione’s key role in selenosemicarbazone and thiosemicarbazone anticancer activity.…”
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Raw data.
Published 2025“…Blocking CD36 function with SSO further decreased viral infectivity, demonstrating the critical role of lipid uptake in HSV-1 life cycle. …”
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