Showing 1,661 - 1,680 results of 23,096 for search '(( significant ((role decrease) OR (fold increases)) ) OR ( significant decrease decrease ))', query time: 0.54s Refine Results
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    Placebo test. by Le Zhu (1771669)

    Published 2025
    Subjects:
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    Advantages of Novel Anti-cancer Selenosemicarbazones: Preferential Reactivity of Their Fe(III), Cu(II), and Zn(II) Complexes with Key Physiological Reductants/Ligands Versus Isoste... by Mahendiran Dharmasivam (14165426)

    Published 2025
    “…Considering this: (1) [Fe(PPP4pSe)<sub>2</sub>]<sup>+</sup> demonstrated increased reduction relative to [Fe(PPP4pT)<sub>2</sub>]<sup>+</sup> with glutathione and l-cysteine, while l-ascorbate led to comparable reduction; (2) glutathione led to complete dissociation of [Zn(PPP4pSe)<sub>2</sub>], while incomplete dissociation of [Zn(PPP4pT)<sub>2</sub>] occurred; and (3) [Cu(PPP4pSe)Cl] demonstrated complete coordinate sphere substitution with glutathione, l-cysteine, and l-ascorbate, whereas [Cu(PPP4pT)Cl] demonstrated partial substitution. The role of glutathione in all three latter reactions is significant, given the greater reactivity of the selenosemicarbazone, and glutathione’s key role in selenosemicarbazone and thiosemicarbazone anticancer activity.…”
  20. 1680

    Advantages of Novel Anti-cancer Selenosemicarbazones: Preferential Reactivity of Their Fe(III), Cu(II), and Zn(II) Complexes with Key Physiological Reductants/Ligands Versus Isoste... by Mahendiran Dharmasivam (14165426)

    Published 2025
    “…Considering this: (1) [Fe(PPP4pSe)<sub>2</sub>]<sup>+</sup> demonstrated increased reduction relative to [Fe(PPP4pT)<sub>2</sub>]<sup>+</sup> with glutathione and l-cysteine, while l-ascorbate led to comparable reduction; (2) glutathione led to complete dissociation of [Zn(PPP4pSe)<sub>2</sub>], while incomplete dissociation of [Zn(PPP4pT)<sub>2</sub>] occurred; and (3) [Cu(PPP4pSe)Cl] demonstrated complete coordinate sphere substitution with glutathione, l-cysteine, and l-ascorbate, whereas [Cu(PPP4pT)Cl] demonstrated partial substitution. The role of glutathione in all three latter reactions is significant, given the greater reactivity of the selenosemicarbazone, and glutathione’s key role in selenosemicarbazone and thiosemicarbazone anticancer activity.…”