First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…”

First Sila-Vitamin D Analogues: Design, Synthesis, Structural Analysis and Biological Activity by Julian Loureiro (20357035)

“…These sila-analogues show similar VDR binding and transcriptional activity in comparison with the natural hormone 1,25D₃, but with significantly less hypercalcemic activity. The new analogues, when combined with chemotherapy, significantly decrease cell proliferation.…”

Data Sheet 1_Global burden of inflammatory bowel disease in the elderly: trends from 1990 to 2021 and projections to 2051.docx by Ying Liu (18461)

“…Death number increased from 14,400 to 33,490, but the age-standardized mortality rate decreased from 3.21 to 2.84 per 100,000. …”

Supplementary file 1_Mechanism of soil microbial community degradation under long-term tomato monoculture in greenhouse.docx by Menglu Li (4458208)

“…Results demonstrated a significant increase in fungal abundance and diversity in >10 years samples, alongside reduced bacterial richness. …”

Presentation 1_Global, regional, and national burden of cardiovascular disease attributable to high body mass index from 1990 to 2021 and projection to 2045.pptx by Hui Li (32376)

“…Over the study period, the overall CVD burden attributable to HBMI decreased significantly, while the burden of atrial fibrillation and flutter increased. …”

Table 2_Mortality and trends of pulmonary arterial hypertension, 1990–2021: a population-based study.docx by Linhong Jiang (5004347)

“…</p>Results<p>The global ASMR of PAH decreased from 0.35 (per 100,000 population) in 1990 to 0.27 (per 100,000 population) in 2021, with an annual percentage change of −0.82, while number of deaths increased from 14,842 in 1990 to 22,021 in 2021, an increase of 48.37%. …”

Table 1_Mortality and trends of pulmonary arterial hypertension, 1990–2021: a population-based study.docx by Linhong Jiang (5004347)

“…</p>Results<p>The global ASMR of PAH decreased from 0.35 (per 100,000 population) in 1990 to 0.27 (per 100,000 population) in 2021, with an annual percentage change of −0.82, while number of deaths increased from 14,842 in 1990 to 22,021 in 2021, an increase of 48.37%. …”

Table 1_Global, regional, and national burden of four major neurological diseases in women from 1990 to 2021.xlsx by Xiaofang Guo (385478)

“…</p>Results<p>In 2021, an estimated 6191564.2, 572999.9, 1536118.7, and 39191.7 new cases of female AD and other dementias, Parkinson’s disease, multiple sclerosis, and idiopathic epilepsy were reported globally, with a significant increase in age-standardized incidence rate (ASIR) from 1990 to 2021. …”

Supplementary file 1_Global, regional, and national burden of four major neurological diseases in women from 1990 to 2021.docx by Xiaofang Guo (385478)

“…</p>Results<p>In 2021, an estimated 6191564.2, 572999.9, 1536118.7, and 39191.7 new cases of female AD and other dementias, Parkinson’s disease, multiple sclerosis, and idiopathic epilepsy were reported globally, with a significant increase in age-standardized incidence rate (ASIR) from 1990 to 2021. …”

Table 3_Mortality and trends of pulmonary arterial hypertension, 1990–2021: a population-based study.docx by Linhong Jiang (5004347)

“…</p>Results<p>The global ASMR of PAH decreased from 0.35 (per 100,000 population) in 1990 to 0.27 (per 100,000 population) in 2021, with an annual percentage change of −0.82, while number of deaths increased from 14,842 in 1990 to 22,021 in 2021, an increase of 48.37%. …”

Data_Sheet_1_Effects of stand age and soil microbial communities on soil respiration throughout the growth cycle of poplar plantations in northeastern China.pdf by Xiangrong Liu (380124)

“…As stand age increased, Rs showed a significant decreasing trend. …”

Table 1_Relationship between nocturia, depression, and cognitive function and the mediating effects of nutritional indexes in older adults: data from NHANES 2011–2014.docx by Yin Xu (159474)

“…Thus, improving nutrition may decrease the risk of nocturia in older adults.</p>…”

Results of Welch’s t-test. by Yachiyo Tobita (20613887)

“…<div><p>The COVID-19 pandemic triggered social and economic stagnation worldwide, significantly impacting people’s lives. In addition, the Russia-Ukraine war that began in 2022 resulted in rising food prices globally, severely affecting low- and middle-income countries. …”

<b>Metabolic shifts in ratio of ucOcn to cOcn towards bone resorption contribute to age-dependent bone loss in male mice</b> by Bin Wang (16631220)

“…Our findings further demonstrated that the increase in osteoclast activity and the decrease in osteoblast function were significantly corelated with blood levels of ucOcn and cOcn, respectively. …”

Table 1_Molecular hybridization modification improves the stability and immunomodulatory activity of TP5 peptide.docx by Junyong Wang (3807964)

“…The half-life of YTP in plasma is significantly longer than that of YW12D and TP5. YTP also displays an improved ability to protect the host from CTX-induced weight loss and thymus and spleen indices decrease than YW12D and TP5. …”

Table 2_Prevalence of pathogens from clinical samples associated with porcine respiratory and digestive diseases in South Korea from 2021 to 2023.docx by Hye-young Wang (8786045)

“…Among these pathogens, porcine reproductive and respiratory syndrome virus (PRRSV, n = 11,997, 56.7%, 95% CI: 56.1%−57.4%) and rotavirus (n = 4,430, 62.1%, 95% CI: 60.93%−63.2%) were the most prevalent. The trends in 3-year prevalence showed no significant changes, but in 2023, viral infections (e.g., PRRSV, Rotavirus, porcine epidemic diarrhea virus, etc.) decreased and bacterial infections (e.g., Mycoplasma hyopneumoniae (MH), Pasteurella multocida (PM), Haemophilus parasuis (HP), Salmonella spp., Lawsonia intracellularis, and Brachyspira hyodysenteriae) slightly increased (χ² = 11.36, P < 0.001). …”

Table 1_Prevalence of pathogens from clinical samples associated with porcine respiratory and digestive diseases in South Korea from 2021 to 2023.docx by Hye-young Wang (8786045)

“…Among these pathogens, porcine reproductive and respiratory syndrome virus (PRRSV, n = 11,997, 56.7%, 95% CI: 56.1%−57.4%) and rotavirus (n = 4,430, 62.1%, 95% CI: 60.93%−63.2%) were the most prevalent. The trends in 3-year prevalence showed no significant changes, but in 2023, viral infections (e.g., PRRSV, Rotavirus, porcine epidemic diarrhea virus, etc.) decreased and bacterial infections (e.g., Mycoplasma hyopneumoniae (MH), Pasteurella multocida (PM), Haemophilus parasuis (HP), Salmonella spp., Lawsonia intracellularis, and Brachyspira hyodysenteriae) slightly increased (χ² = 11.36, P < 0.001). …”

Identifying hotspots of urbanization and agricultural growth: a spatio-temporal analysis of land use dynamics in Tolga, Algeria (1994–2024) by Mohamed Akram Eddine Ben Ratmia (21662098)

“…<p>Land use and land cover (LULC) changes driven by urbanization and agricultural expansion pose significant challenges to biodiversity, water resources, and sustainable development, particularly in arid and semi-arid regions. …”

Image 2_Prognostic model construction and immune microenvironment analysis of pyroptosis-related genes in hepatocellular carcinoma based on single-cell RNA sequencing.tiff by Haoming Shen (3816988)

“…The prognostic model developed in this study stratified patients into high-risk and low-risk categories based on eight significant genes, achieving area under the curve (AUC) values of 0.73, 0.65, and 0.69 for overall survival at one-year, two-year, and three-year intervals, respectively. …”

Image 1_Prognostic model construction and immune microenvironment analysis of pyroptosis-related genes in hepatocellular carcinoma based on single-cell RNA sequencing.tiff by Haoming Shen (3816988)

“…The prognostic model developed in this study stratified patients into high-risk and low-risk categories based on eight significant genes, achieving area under the curve (AUC) values of 0.73, 0.65, and 0.69 for overall survival at one-year, two-year, and three-year intervals, respectively. …”