AMP binding free energy calculations and per-residue decomposition of holo and PfIleRS-SANC systems. by Curtis Chepsiror (21368103)

Fig 9 - BC. by Curtis Chepsiror (21368103)

Effects of DA-9701 on cellular and molecular markers in STZ-induced diabetic rats. by Minjun Kim (1588486)

“…STZ treatment upregulated c-Kit expression, which was significantly modulated by DA-9701 (*p < 0.05, **p < 0.01). …”

Systemic Inflammation associated with a 24-hour septic insult [cecal slurry (CS; 1.6mg/g) + hyperoxia (HO; 95% O₂)] in female MMP7KO mice and their wild-type littermates... by Brandon Baer (21276471)

“…Although female septic MMP7KO mice showed similar numerical increases across all pro-inflammatory cytokines, they were not significantly different compared to MMP7KO controls. …”

Lung and Kidney Matrix Metalloproteinase Expression induced by a septic insult [cecal slurry (CS; 1.6mg/g) + hyperoxia (HO; 95% O₂)] in male MMP7KO mice and their wild-t... by Brandon Baer (21276471)

“…Septic mice (both WT and MMP7KO) showed numerical increases in kidney MMP9 mRNA expression compared to control mice. …”

Kidney Dysfunction, Inflammation, and Injury induced by a septic insult [cecal slurry (CS; 1.6mg/g) + hyperoxia (HO; 95% O₂)] in MMP7KO mice and their wild-type litterma... by Brandon Baer (21276471)

Fig 10 - EC. by Curtis Chepsiror (21368103)

Systemic Inflammation associated with a 24-hour septic insult [cecal slurry (CS; 1.6mg/g) + hyperoxia (HO; 95% O₂)] in male MMP7KO mice and their wild-type littermates. by Brandon Baer (21276471)

“…Male septic MMP7KO mice showed significantly higher peritoneal inflammatory cell counts compared to control MMP7KO mice. …”

Lung inflammation induced by a septic insult [cecal slurry (CS; 1.6mg/g) + hyperoxia (HO; 95% O₂)] in female MMP7KO mice compared to their wild-type littermates. by Brandon Baer (21276471)

“…Although septic MMP7KO mice showed similar numerical increases they were not significantly different compared to MMP7KO controls. …”

AI-Driven Discovery and Optimization of Positive Allosteric Modulators for NMDA Receptors: Potential Applications in Depression by Tingting Yang (166111)

“…In this study, using structure-based virtual screening and artificial intelligence (AI)-assisted optimization, we identified <b>Y36</b>, a benzene-substituted piperidinol derivative and potent GluN2A-selective PAM. <b>Y36</b> showed higher efficacy (<i>E</i>_max = 397.7%) than GNE-3419 (<i>E</i>_max = 196.4%), reducing the EC₅₀ values and increasing the <i>E</i>_max values for glutamate/glycine at GluN2A receptor. …”

AI-Driven Discovery and Optimization of Positive Allosteric Modulators for NMDA Receptors: Potential Applications in Depression by Tingting Yang (166111)

“…In this study, using structure-based virtual screening and artificial intelligence (AI)-assisted optimization, we identified <b>Y36</b>, a benzene-substituted piperidinol derivative and potent GluN2A-selective PAM. <b>Y36</b> showed higher efficacy (<i>E</i>_max = 397.7%) than GNE-3419 (<i>E</i>_max = 196.4%), reducing the EC₅₀ values and increasing the <i>E</i>_max values for glutamate/glycine at GluN2A receptor. …”

AI-Driven Discovery and Optimization of Positive Allosteric Modulators for NMDA Receptors: Potential Applications in Depression by Tingting Yang (166111)

“…In this study, using structure-based virtual screening and artificial intelligence (AI)-assisted optimization, we identified <b>Y36</b>, a benzene-substituted piperidinol derivative and potent GluN2A-selective PAM. <b>Y36</b> showed higher efficacy (<i>E</i>_max = 397.7%) than GNE-3419 (<i>E</i>_max = 196.4%), reducing the EC₅₀ values and increasing the <i>E</i>_max values for glutamate/glycine at GluN2A receptor. …”

AI-Driven Discovery and Optimization of Positive Allosteric Modulators for NMDA Receptors: Potential Applications in Depression by Tingting Yang (166111)

“…In this study, using structure-based virtual screening and artificial intelligence (AI)-assisted optimization, we identified <b>Y36</b>, a benzene-substituted piperidinol derivative and potent GluN2A-selective PAM. <b>Y36</b> showed higher efficacy (<i>E</i>_max = 397.7%) than GNE-3419 (<i>E</i>_max = 196.4%), reducing the EC₅₀ values and increasing the <i>E</i>_max values for glutamate/glycine at GluN2A receptor. …”

AI-Driven Discovery and Optimization of Positive Allosteric Modulators for NMDA Receptors: Potential Applications in Depression by Tingting Yang (166111)

“…In this study, using structure-based virtual screening and artificial intelligence (AI)-assisted optimization, we identified <b>Y36</b>, a benzene-substituted piperidinol derivative and potent GluN2A-selective PAM. <b>Y36</b> showed higher efficacy (<i>E</i>_max = 397.7%) than GNE-3419 (<i>E</i>_max = 196.4%), reducing the EC₅₀ values and increasing the <i>E</i>_max values for glutamate/glycine at GluN2A receptor. …”

AI-Driven Discovery and Optimization of Positive Allosteric Modulators for NMDA Receptors: Potential Applications in Depression by Tingting Yang (166111)

“…In this study, using structure-based virtual screening and artificial intelligence (AI)-assisted optimization, we identified <b>Y36</b>, a benzene-substituted piperidinol derivative and potent GluN2A-selective PAM. <b>Y36</b> showed higher efficacy (<i>E</i>_max = 397.7%) than GNE-3419 (<i>E</i>_max = 196.4%), reducing the EC₅₀ values and increasing the <i>E</i>_max values for glutamate/glycine at GluN2A receptor. …”

Flowchart of the methodology. by Md. Sakib Hasan (20536529)

“…Furthermore, the cooking loss increased non-significantly (<i>p </i>> 0.05) among treated samples due to lower moisture and fat loss. …”

Preparation of fish ball. by Md. Sakib Hasan (20536529)

“…Furthermore, the cooking loss increased non-significantly (<i>p </i>> 0.05) among treated samples due to lower moisture and fat loss. …”

Raw data of this research work. by Md. Sakib Hasan (20536529)

“…Furthermore, the cooking loss increased non-significantly (<i>p </i>> 0.05) among treated samples due to lower moisture and fat loss. …”

Primer sequence of genes. by Wajeeha Komal (17873637)

“…<div><p>Increasing aquaculture production requires high-density farming, which induces stress, necessitating supplements to mitigate its effects and ensure fish health. …”

S1 Data - by Wajeeha Komal (17873637)

“…<div><p>Increasing aquaculture production requires high-density farming, which induces stress, necessitating supplements to mitigate its effects and ensure fish health. …”