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Serum metabolic signatures for Alzheimer’s Disease reveal alterations in amino acid composition: a validation study
منشور في 2024"…<h3>Introduction</h3><p dir="ltr">Alzheimer’s Disease (AD) is complex and novel approaches are urgently needed to aid in diagnosis. …"
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Spectrum of genetic variants associated with maple syrup urine disease in the Middle East, North Africa, and Türkiye (MENAT): a systematic review
منشور في 2025"…<h3>Background</h3><p dir="ltr">Maple syrup urine disease (MSUD) is a hereditary metabolic disorder caused by a deficiency in the branched-chain α-keto acid dehydrogenase (BCKD) enzymatic complex. …"
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Next-generation nanoparticles for cancer and autoimmune therapy
منشور في 2025"…Additionally, dual-function NPs designed to target multiple immune pathways simultaneously are examined, offering innovative solutions for complex diseases. Despite ongoing challenges related to compatibility, safety, and scalability, the integration of nanotechnology with immune modulation presents significant potential to transform therapeutic outcomes. …"
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GLP-1 receptor agonists, are we witnessing the emergence of a paradigm shift for neuro-cardio-metabolic disorders?
منشور في 2025"…The <u>neuroprotective </u>attributes of GLP-1 RAs have garnered significant interest, with research indicating their potential to alleviate cognitive decline associated with <u>neurodegenerative diseases</u>. …"
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Enhanced coronary artery segmentation and stenosis detection: Leveraging novel deep learning techniques
منشور في 2025"…<p dir="ltr">Coronary artery disease (CAD) is a significant global health concern, emphasizing the need for reliable and automated diagnostic solutions. …"
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A Comprehensive Analysis of Healthcare Big Data Management, Analytics and Scientific Programming
منشور في 2020"…Scientific programming play a significant role to overcome the existing issues and future problems involved in the management of large scale data in healthcare, such as by assisting in the processing of huge data volumes, complex system modelling, and sourcing derivations from healthcare data and simulations. …"
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Clinical diagnostic reference levels in neuroradiology based on clinical indication
منشور في 2024"…<p dir="ltr">This study focuses on patient radiation exposure in interventional neuroradiology (INR) procedures, a field that has advanced significantly since its inception in the 1980s. INR employs minimally invasive techniques to treat complex cerebrovascular diseases in the head, neck, and spine. …"
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The efficacy of transcranial direct current stimulation in patients with medication overuse headaches secondary to chronic migraines (P4.128)
منشور في 2018"…There was also a significant decrease in the consumption of analgesic medications in the DLPFC group and in the pain intensity in the Occipital group. …"
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A novel hybrid methodology for fault diagnosis of wind energy conversion systems
منشور في 2023"…Feature selection pre-processing is an important step to increase the accuracy of the classification algorithm and decrease the dimensionality of a dataset. …"
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Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
منشور في 2020"…In the mouse model, R. coriaria at a higher dose (1%) significantly decreased tumor volume by 27% when compared to controls. …"
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Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-...
منشور في 2025"…The high discontinuation rate and results of the STAND trial led to a significant decrease in the use of crizanlizumab. The HOPE trial demonstrated a 51 % improvement in hemoglobin response and a reduction in hemolytic markers in patients treated with voxelotor. …"
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Managing Endothelial Dysfunction in COVID-19
منشور في 2022"…Furthermore, there were no statistically significant differences in the need for mechanical ventilation or ICU admission, all-cause mortality, and the occurrence of side effects between the endothelial protocol group and the placebo group. …"
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Communication Network for Ultrasonic Acoustic Water Leakage Detectors
منشور في 2020"…Acoustic detectors were found the most suitable technology for the atmosphere in UAE, where the levels of humidity and, consequently, soil moisture are high, because both of GPRs and IR cameras operational capability to detect leaks tend to decrease sharply as soil moisture increases. On the other side, a conventional acoustic detector has very limited scope of detection. …"
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F-box proteins in cancer stemness: An emerging prognostic and therapeutic target
منشور في 2021"…<p dir="ltr">Cancer is a complex heterogenic disease with significant therapeutic challenges. …"
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A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems
منشور في 2021"…The results of the conducted computational experiments indicate that an increase in infrastructure investment through high speed chargers can significantly decrease the size of the necessary fleets. …"