LDH expression is a surrogate for cell death. by Bryan S. Margulies (21492667)

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Diagrammatic illustration showing the time-course of the experimental set-up as well as the experimental endpoints. by Bryan S. Margulies (21492667)

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Mice in the NTC and MBC-005 treatment groups were evaluated for bioluminescent signaling at 6-, 13-, and 21-days after tumor inoculation. by Bryan S. Margulies (21492667)

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Echogenic properties were assessed using a portable ultrasound, similar to the devices that are used clinically. by Bryan S. Margulies (21492667)

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MCF7 cultures were treated with either MBC-005 or doxorubicin. by Bryan S. Margulies (21492667)

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Cox proportional hazard ratios. by Bryan S. Margulies (21492667)

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Liver samples were stained with hematoxylin and eosin and imaged at 4x. by Bryan S. Margulies (21492667)

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Bioluminescent Doubling Time. by Bryan S. Margulies (21492667)

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Study Design. by Bryan S. Margulies (21492667)

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Liver weights were normalized by the mouse body weight to derive the %liver weight. by Bryan S. Margulies (21492667)

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Histomorphometric analysis of the tumor volume fraction (V_f) in the liver and necrosis volume fraction. by Bryan S. Margulies (21492667)

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(A) Release rate (i.e., elution) of N-allyl noroxymorphone hydrochloride evaluated using UPLC from two samples of MBC-005. The equations predict that at 24-hours there will be betw... by Bryan S. Margulies (21492667)

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The MTT assay and the LDH assay were used to assess the effects of the hydrogel component of MBC-005 on tumor cell number and cell death. by Bryan S. Margulies (21492667)

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The spheroid assay is used to assess long-term effects of therapy on tumor cell by culturing the tumor cells in a micro-mass, which is a 3D tumor mass used as a surrogate for in vi... by Bryan S. Margulies (21492667)

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Survival in mice with liver metastases after MBC-005 TREATMENT. by Bryan S. Margulies (21492667)

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Inhibitor versus the normalized dose response curves. by Bryan S. Margulies (21492667)

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Viscosity assessed using a tuning-fork viscometer. by Bryan S. Margulies (21492667)

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Interpolated survival in mice with or without lung metastases. by Bryan S. Margulies (21492667)

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The p21 ELISA assay was used to assess the effects of MBC-005 on tumor cell expression of p21. by Bryan S. Margulies (21492667)

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Ictogenic changes in input correlation and adaptation gains are associated with increased dynamical variability during baseline activity. by Scott Rich (9873638)

“…<b>B</b>: <i>U</i>_<i>e</i> and <i>U</i>_<i>i</i> Normalized SD during baseline activity (top) and SLE rate (bottom) in the default model compared to two non-ictogenic scenarios— decreased from 50.0 to 40.0 and decreased from 1.2 to .8. …”