Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity حسب Mohammed R. Shaker (10316180)

"…Our data reveal that upregulation of <i>KLOTHO</i> significantly reduced β-amyloid-induced neuronal degeneration and apoptosis, as evidenced by decreased cleaved caspase-3 expression and preservation of axonal integrity. …"

How global spine sagittal alignment and spinal degeneration affect locomotive syndrome risk in the elderly حسب Ramada R. Khasawneh (6837734)

"…As LS risk increased, LBP prevalence and VAS scores rose, physical abilities, and back muscle strength decreased. TKA showed no variation across groups, while LLA decreased with advancing LS risk stage. …"

The effect of Dopamine Agonists on patients with advanced Parkinson's disease subjected to subthalamic deep brain stimulation. (c2000) حسب Jabre, Mazen Gerges

"…Striatal dopamine concentration gets significantly reduced, and clinical symptoms, especially the motor handicap, prevail. …"
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Diffusion tensor imaging with tractography in surgical resection of brainstem cavernous malformations: a systematic review and meta-analysis حسب Mohammed Maan Al-Salihi (13105835)

"…The utilization of preoperative diffusion tensor imaging significantly increased the proportion of improved patients and decreased the proportion of worsened patients. …"

An additive manufacturing approach based on electrohydrodynamic printing to fabricate P3HT:PCBM thin films حسب Zulfikre Esa (19457344)

"…The root-mean-square roughness was found to vary significantly with the annealing temperature and the flow rate and ranged from 1.938 to 3.345 nm. …"

Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice حسب Ann Van der Jeugd (18629695)

"…Chronic sodium selenate treatment efficiently reversed hippocampal-dependent learning and memory impairments, and behavior- and neuropsychiatric-like symptoms in old female 3xTg-AD mice. Selenium significantly decreased the number of aggregated tau-positive neurons and astrogliosis, without globally affecting amyloid plaques, in the hippocampus of 3xTg-AD mice. …"

STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration حسب Ayat S. Hammad (9592374)

"…SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. …"

Independent and Combined Effects of Antioxidant Supplementation and Circuit Resistance Training on Selected Adipokines in Postmenopausal Women حسب Ayoub Saeidi (17331085)

"…Our findings demonstrated that visfatin, vaspin, and leptin levels significantly decreased over the intervention period (all p < 0.05), with these values were lower in EG and ZMEG in comparison to CG at post-intervention (all p < 0.05). …"

The effect of microbiome therapy on COVID-19-induced gut dysbiosis: A narrative and systematic review حسب Mahmoud Yousef (9900837)

"…</p><p><br></p><h3>Significance</h3><p dir="ltr">The insights gleaned from this review significantly contribute to our broader comprehension of the therapeutic potential of biotics in addressing COVID-19-related gut dysbiosis and mitigating secondary multi-organ complications.…"

Impact of staying at home measures during COVID-19 pandemic on the lifestyle of Qatar’s population: Perceived changes in diet, physical activity, and body weight حسب Muna Abed Alah (14779534)

"…Despite the benefits gained from such measures in containing the spread of the infection, adverse lifestyle consequences happened. In this study we aimed to assess the impact of staying at home measures imposed during COVID-19 pandemic on dietary behaviors, physical activity, and body weight in Qatar’s population. …"

The Effect of EVA and TPU Custom Foot Orthoses on Running Economy, Running Mechanics, and Comfort حسب Ken Van Alsenoy (14150559)

"…Braking force was decreased by 3.4±9.1% at LS and by 2.7±9.8% at HS for EVA compared to CON (P = 0.03, η² = 0.20). …"

Associations between Bone Mineral Density and WOMAC Scores in Healthy Individuals: Insights from the Qatar Biobank حسب Mohammed Al-Hamdani (16962702)

"…However, BMD measures significantly contributed to predicting stiffness after controlling for sociodemographic variables (R² = 0.065, ΔF(7, 1724) = 3.34, p= 0.002), with a higher total body BMD associated with increased stiffness and a higher trunk BMD associated with decreased stiffness. …"

Anti-xa guided enoxaparin thromboprophylaxis is associated with less thromboembolism than fixed dose dalteparin in trauma patients admitted to intensive care حسب Ahmad Kloub (16855149)

"…Low-molecular-weight heparin (LMWH) is recommended for VTE prophylaxis (VTEp). We investigated whether switching from fixed-dose dalteparin to anti-Xa-guided enoxaparin prophylaxis reduces VTE without increasing the risk of bleeding among hospitalized trauma patients.…"

Masked phenomenon: renal and cardiovascular complications; review and updates حسب Elmukhtar Habas (14777677)

"…Normal blood pressure should be 120/80 mmHg, which generally decreases when a person is sleeping or sitting. High blood pressure or hypertension occurs when the blood pressure is too high. …"

Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity حسب Mohamed Abu-Farha (18535590)

"…In functional assays, our data indicated that ectopic expression of HDAC4 significantly impaired TNF-α-dependent activation of NF-κB, establishing thus a link between HDAC4 and regulation of the immune system. …"

Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer حسب Sampath, Lakshmi

"…Results: (DTPA)n-trastuzumab-(IRDye800)m showed significantly greater binding to SKBr3 cells than to MDA-MB-231 cells. …"
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Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burd... حسب Katherine R Paulson (8674293)

"…</p><p><br></p><h3>Methods</h3><p dir="ltr">We completed all-cause mortality and cause-specific mortality analyses from 204 countries and territories for detailed age groups separately, with aggregated mortality probabilities per 1000 livebirths computed for neonatal mortality rate (NMR) and under-5 mortality rate (U5MR). …"

Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential حسب Azza Naïja (19137067)

"…Results from the cardiac function analysis displayed that DEHP significantly affected the arterial pulse and linear velocity within the Posterior Cardinal Vein (PCV) of exposed fish. …"

Driving against the clock: Investigating the impacts of time pressure on taxi and non-professional drivers’ safety and compliance حسب Qinaat Hussain (15294164)

"…When comparing both groups, non-professional drivers displayed higher speeds and riskier behaviors across various scenarios, whereas taxi drivers were more likely to commit violations associated with drop-offs. …"