Supplementary Material for: Comprehensive Genetic Analysis Exploring Sedentary Lifestyle, Physical Activity, and Respiratory Diseases: A Bidirectional Mendelian Randomization with... by Wan W. (4013744)

“…Despite numerous studies, uncertainties and controversies regarding causal relationships persist. We utilized Mendelian randomization (MR) analysis, an advanced statistical tool, to further investigate causal links. …”

Table 1_BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome.docx by Man Zhao (314232)

“…Furthermore, silencing BNIP3 leads to a significant reduction in mitochondrial damage and mtROS production. …”

Table 3_PitNET tissue deconvolution: tracing normal tissue residues and immune dynamics.xlsx by Mattia Dalle Nogare (22696022)

“…However, its limited ability to resolve cellular heterogeneity – particularly in samples containing residual non-tumor pituitary cells – remains a significant challenge.</p>Objective<p>We developed and validated a tissue deconvolution framework using a reference dataset derived from single-nucleus RNA sequencing (snRNA-seq) of normal pituitary tissue, aimed at estimating cellular composition in PitNETs from bulk RNA-seq data and characterizing the tumor microenvironment (TME).…”

Data Sheet 1_Uncovering the heterogeneity of NK cells on the prognosis of HCC by integrating bulk and single-cell RNA-seq data.csv by Jiashuo Li (7865036)

“…Immunohistochemistry showed that HRG expression was decreased in HCC compared to normal tissues, whereas TUBA1B expression was elevated in HCC.…”

DataSheet2_Deficiency of autism susceptibility gene Trio in cerebellar Purkinje cells leads to delayed motor impairments.zip by Jinxin Wang (1696837)

“…The decreased expression of Calbindin existed in both 12-week and 20-week old mice compared with control. …”

The role of IRF-1 in mediating T-cell immune imbalance in systemic lupus erythematosus and the construction of a diagnostic model by Zichen Huang (6587885)

“…The role of interferon regulatory factor-1 (IRF-1) remains unclear. We integrated single-cell transcriptomes (scRNA-seq; GSE254176), 6 bulk transcriptomic datasets (1079 SLE patients, 137 controls, GSE72326 and GSE61635 were merged as training datasets, including 256 SLE patients and 50 controls), and clinical samples (70 SLE patients and 58 controls). …”

Table 2_Body Mass Index mediates the associations between dietary approaches to stop hypertension and obstructive sleep apnea among U.S. adults.docx by Songtao Li (186776)

“…</p>Conclusion<p>These findings suggested that DASH decreased OSA risk, which was possibly and partly mediated by BMI.…”

Aetiology, clinical characteristics, and risk factors influencing mortality in patients with infective endocarditis: a retrospective study by Özkan Vural (21470515)

“…Despite advancements in diagnosis and treatment, incidence and mortality rates have not decreased. In this study, we evaluated the clinical and laboratory parameters of patients with infective endocarditis followed in our hospital between 2005 and 2018 and assessed their relationship with in-hospital and one-year mortality.…”

Image 1_Immunosuppressants in dermatology on vaccine immunogenicity: a prospective cohort study of pemphigus patients in the pandemic.tif by Kun-Lin Lu (7256960)

“…All pemphigus patients demonstrated improved antibody responses after the third vaccination and none of them suffered from severe COVID-19 illness. Intriguingly, we found that daily dosages of 100 mg or more of azathioprine were linked to significantly decreased anti-viral T-cell responses induced by the vaccination (mean of fold change [SD]; higher azathioprine dosage = 0.70 [0.61] folds vs. lower azathioprine dosage = 2.11 [1.03] folds; p = 0.044).…”

Image 2_Immunosuppressants in dermatology on vaccine immunogenicity: a prospective cohort study of pemphigus patients in the pandemic.tif by Kun-Lin Lu (7256960)

“…All pemphigus patients demonstrated improved antibody responses after the third vaccination and none of them suffered from severe COVID-19 illness. Intriguingly, we found that daily dosages of 100 mg or more of azathioprine were linked to significantly decreased anti-viral T-cell responses induced by the vaccination (mean of fold change [SD]; higher azathioprine dosage = 0.70 [0.61] folds vs. lower azathioprine dosage = 2.11 [1.03] folds; p = 0.044).…”

Image 1_Uncovering the heterogeneity of NK cells on the prognosis of HCC by integrating bulk and single-cell RNA-seq data.jpeg by Jiashuo Li (7865036)

“…Immunohistochemistry showed that HRG expression was decreased in HCC compared to normal tissues, whereas TUBA1B expression was elevated in HCC.…”

Synergy is not captured by low-dimensional manifolds. by Thomas F. Varley (8446899)

“…<p><b>Top left:</b> For significantly redundancy-dominated triads, the normalized O-information is strongly correlated with the variance explained by the first principal component, indicating that as the overall amount of redundancy increases, the degree of compressibility does as well. …”

<b>Three-dimensional analysis of the horizontal condylar angle in the temporomandibular joint: morphology and surgical implications</b> by Mingqi Ma (22228960)

“…In the disc repositioning group, HCA decreased significantly after surgery.<b>Conclusions. …”

Image 3_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff by Marisa R. Young (7919255)

“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”

Table 2_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.docx by Marisa R. Young (7919255)

“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”

Image 2_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff by Marisa R. Young (7919255)

“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”

Image 11_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff by Marisa R. Young (7919255)

“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”

Image 7_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff by Marisa R. Young (7919255)

“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”

Image 8_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff by Marisa R. Young (7919255)

“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”

Image 6_No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.tiff by Marisa R. Young (7919255)

“…There were statistically significant but moderate absolute decreases in proportion of CD45+ and CD4+ T cells in CVL, and CD4+ T cells in blood, and increased proportion of CD69+ T cells in blood post-HC. …”