Supplementary Material for: Efficacy and safety of finerenone in Asian patients with type 2 diabetes and chronic kidney disease: A FIDELITY analysis by figshare admin karger (2628495)

“…Methods For this subanalysis, efficacy outcomes included a CV composite (time to CV death, non-fatal myocardial infarction, non-fatal stroke or hospitalization for heart failure) and kidney composite (kidney failure, sustained ≥57% estimated glomerular filtration rate [eGFR] decrease from baseline over ≥4 weeks or renal death) outcome. …”

List of DEGs from neuronal cell analysis. by Sara Cuvertino (18892069)

“…In contrast with the epigenomic changes, the number of DEGs decrease as differentiation progresses. Our analysis reveals significant enrichment of differentially downregulated genes in areas containing putative enhancer regions with H3K4me1 loss. …”

Table 1_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx by Bin Liao (714989)

“…Simultaneous knockout of HIF1α and HIF2α in GBM cells resulted in the highest LDH release and apoptosis rates under hypoxic conditions, accompanied by the most significant decrease in IGF1R, p-PDK1, and p-AKT levels. …”

Table 7_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.xlsx by Joanna Palade (17712960)

“…Next, we examined the functional capabilities of patient NKEVs in organoid structures derived from primary tumor cells, finding that exposure to patient NKEVs resulted in a 40-45% decrease in organoid viability, and significantly lowered the cisplatin dose required to elicit cytotoxicity. …”

Image 1_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.jpg by Joanna Palade (17712960)

“…Next, we examined the functional capabilities of patient NKEVs in organoid structures derived from primary tumor cells, finding that exposure to patient NKEVs resulted in a 40-45% decrease in organoid viability, and significantly lowered the cisplatin dose required to elicit cytotoxicity. …”

Table 8_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.xlsx by Joanna Palade (17712960)

“…Next, we examined the functional capabilities of patient NKEVs in organoid structures derived from primary tumor cells, finding that exposure to patient NKEVs resulted in a 40-45% decrease in organoid viability, and significantly lowered the cisplatin dose required to elicit cytotoxicity. …”

Image5_A distinct immune landscape in anti-synthetase syndrome profiled by a single-cell genomic study.jpeg by Jiayu Ding (12005975)

“…</p>Results<p>After meticulous annotation of PBMCs, we noticed a significant decrease in the proportion of mucosal-associated invariant T (MAIT) cells in ASS patients compared to HCs, while there was a notable increase in the proportion of proliferative NKT cells. …”

Inclusion and exclusion table. by Tong-jie Yang (20939652)

“…</p><p> Conclusion </p><p>(1) HU can effectively contribute to the evaluation of bone and soft tissue densities in the proximal femur, and reflect local stress changes. (2) In ONFH patients, bone density does not decrease in the necrotic area of the femoral head before collapse. …”

Table 1_Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation.docx by Weilong Li (8778146)

“…Importantly, the loss of Claudin-2 significantly decreased the deposition of the C5b-9 complex, commonly referred to as the membrane attack complex (MAC), whereas the overexpression of Claudin-2 enhanced the deposition of the C5b-9 complex, indicating that Claudin-2 facilitates complement activation. …”

Image3_A distinct immune landscape in anti-synthetase syndrome profiled by a single-cell genomic study.jpeg by Jiayu Ding (12005975)

“…</p>Results<p>After meticulous annotation of PBMCs, we noticed a significant decrease in the proportion of mucosal-associated invariant T (MAIT) cells in ASS patients compared to HCs, while there was a notable increase in the proportion of proliferative NKT cells. …”

Image 4_CXCR7-TAGLN2 protein complex regulates invasion and metastasis in papillary thyroid carcinoma: a potential therapeutic target.tif by Chao Zeng (452370)

“…High expression of both proteins was significantly associated with lymph node metastasis in PTC patients, and a significant positive correlation was observed between CXCR7 and TAGLN2 expression levels. …”

Image 1_The role of Sophora alopecuroides alkaloids in colon health of lambs fed high-concentrate diets for extended periods: impact on barrier function, antioxidation, and microfl... by Shufang Li (3183168)

“…The concentration of propionate and lactate in colon contents in HC group increased significantly, while the pH decreased significantly (p < 0.05). …”

Table 4_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.xlsx by Joanna Palade (17712960)

“…Next, we examined the functional capabilities of patient NKEVs in organoid structures derived from primary tumor cells, finding that exposure to patient NKEVs resulted in a 40-45% decrease in organoid viability, and significantly lowered the cisplatin dose required to elicit cytotoxicity. …”

Data Sheet 2_Liver X receptor agonist T0901317 alleviates sepsis-induced acute lung injury by enhancing macrophage autophagy.csv by Ben Wang (250897)

“…Analysis of the human transcriptome data revealed a significant negative correlation between LXRα and S100A8 (R = −0.98, p < 0.001).…”

Mass spectrum of 7-MH. by Juthamart Maneenet (15999769)

“…<div><p>Pancreatic cancer presents a significant therapeutic challenge characterized by poor survival rates, leading to development of innovative treatment strategies. …”

Image 1_Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice.pdf by Yan Gong (103494)

“…Additionally, MA notably inhibited osteoclast activity, as evidenced by a decrease in the number of osteoclasts and a significant suppression of F-actin formation. …”

Table 2_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx by Bin Liao (714989)

“…Simultaneous knockout of HIF1α and HIF2α in GBM cells resulted in the highest LDH release and apoptosis rates under hypoxic conditions, accompanied by the most significant decrease in IGF1R, p-PDK1, and p-AKT levels. …”

Co-immunoprecipitation and BiFC experiments related to Abd-B and Exd interaction. by Jesús R. Curt (20553231)

“…Protein present in the co-IPs is indicated above the gels. There is a significant decrease in the amount of the Abd-B^W protein captured on the resin when compared to the Abd-B wildtype protein (24%), while Exd remains almost unchanged (2%). …”

Image3_Fever management in children and insights into fever of unknown origin: a survey among Italian pediatricians.jpeg by Elena Chiappini (304802)

“…Compared to what participants reported for the treatment of non-prolonged fever, a significant decrease in the prescription of paracetamol as first-choice drug in children with FUO was observed (80.5%; P < 0.0001). …”

Table1_A distinct immune landscape in anti-synthetase syndrome profiled by a single-cell genomic study.docx by Jiayu Ding (12005975)

“…</p>Results<p>After meticulous annotation of PBMCs, we noticed a significant decrease in the proportion of mucosal-associated invariant T (MAIT) cells in ASS patients compared to HCs, while there was a notable increase in the proportion of proliferative NKT cells. …”