يعرض 18,281 - 18,300 نتائج من 21,342 نتيجة بحث عن '(( significant (challenge OR challenges) decrease ) OR ( significant decrease decrease ))', وقت الاستعلام: 0.41s تنقيح النتائج
  1. 18281

    Table 3_Efgartigimod for the treatment of immune checkpoint inhibitor-associated myocarditis complicated with impending crisis state of myasthenia gravis: a case report.docx حسب Mingjia Lu (21593324)

    منشور في 2025
    "…Treatment with efgartigimod (10 mg/kg) significantly improved myasthenic symptoms, with Myasthenia Gravis–Activities of Daily Living (MG-ADL) and Quantitative Myasthenia Gravis (QMG) scores decreasing from 11 to 5 and 26 to 11, respectively. …"
  2. 18282

    Evening Micro-Sprinkler Pavement Cooling / Riego Microaspersor Vespertino para Pavimentos حسب Ricardo Riveros (22484566)

    منشور في 2025
    "…We propose pilot monitoring in cities with significant urban heat island (UHI) effects, evaluating surface and air temperature reduction, water usage efficiency, and public health impact.…"
  3. 18283

    Figure 5 from KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma حسب Elisabet Figuerola-Bou (22618659)

    منشور في 2025
    "…<p>KDM6A KO decreases Ewing sarcoma tumor growth. <b>A,</b> Colony formation assay of KDM6A KO cells (sgRNA#1 and sgRNA#2) compared with parental cells and sgCTRL in A-673. …"
  4. 18284

    Table 1_Integrated gut microbiota and metabolomic profiling reveals key associations between amino acid levels and gut microbial composition in patients with obesity.docx حسب Musen Qi (22489075)

    منشور في 2025
    "…Metabolomic analysis revealed that in patients with obesity, the abundance of carnosine (log2FC = 1.16, FDR = 0.0016, VIP = 0.707), creatinine (log2FC = 0.21, FDR = 0.0009, VIP = 2.02), and cystine (log2FC = 0.55, FDR = 0.009, VIP = 1.47) was significantly increased compared with that in the controls; in contrast, that of ornithine (log2FC = −0.59, FDR = 0.0009, VIP = 1.19), citrulline (log2FC = −0.59, FDR = 0.0003, VIP = 0.707), glycine (log2FC = −0.54, FDR = 0.0003, VIP = 1.41), and serine (log2FC = −0.38, FDR = 0.0019, VIP = 1.62) was significantly decreased. …"
  5. 18285

    NHR-49/80 mediated FEDUS via the peroxisomal activation. حسب Meiyu Ruan (19929335)

    منشور في 2024
    "…Lower population density significantly decreased palmitic acid-induced AWC maturation. …"
  6. 18286

    Ca<sup>2+</sup> homeostasis and the corpuscles of Stannius regulate sensory gating. حسب Susannah S. Schloss (21238775)

    منشور في 2025
    "…<b>(A)</b> Exposure to high (10 mM) Ca<sup>2+</sup> caused a slight but significant increase in whole-body Ca<sup>2+</sup> levels, compared to normal 0.33 mM Ca<sup>2+</sup> (*<i>p</i> = 0.024). …"
  7. 18287
  8. 18288

    Data Sheet 3_Identification of novel gut microbiota-related biomarkers in cerebral hemorrhagic stroke.zip حسب Fengli Ye (22123540)

    منشور في 2025
    "…Due to ambiguous symptoms and limited biomarkers, early diagnosis and prognosis remain challenging. Recent evidence suggests that gut microbiota dysregulation influences neuroinflammation and outcomes in ICH, but the underlying molecular mechanisms remain unclear.…"
  9. 18289

    A platform for the rapid screening of equine immunoglobins F (ab)2 derived from single equine memory B cells able to cross-neutralize to influenza virus حسب Yuezhi Lin (9287759)

    منشور في 2024
    "…Furthermore, it effectively protected EIV-challenged mice, resulting in significantly improved survival, reduced pulmonary inflammation and decreased viral titers. …"
  10. 18290

    Data Sheet 1_Identification of novel gut microbiota-related biomarkers in cerebral hemorrhagic stroke.zip حسب Fengli Ye (22123540)

    منشور في 2025
    "…Due to ambiguous symptoms and limited biomarkers, early diagnosis and prognosis remain challenging. Recent evidence suggests that gut microbiota dysregulation influences neuroinflammation and outcomes in ICH, but the underlying molecular mechanisms remain unclear.…"
  11. 18291

    Data Sheet 2_Identification of novel gut microbiota-related biomarkers in cerebral hemorrhagic stroke.zip حسب Fengli Ye (22123540)

    منشور في 2025
    "…Due to ambiguous symptoms and limited biomarkers, early diagnosis and prognosis remain challenging. Recent evidence suggests that gut microbiota dysregulation influences neuroinflammation and outcomes in ICH, but the underlying molecular mechanisms remain unclear.…"
  12. 18292

    Data Sheet 1_Efficacy and safety of anlotinib combined with 125I seed implantation for iodine-refractory thyroid cancer.docx حسب Zhijun Chen (254277)

    منشور في 2025
    "…Background and objective<p>Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) remains challenging to treat due to a lack of effective therapies. …"
  13. 18293

    Image 1_A four-gene signature identified by integrated transcriptomic analysis for differential diagnosis and prognosis of uterine smooth muscle tumors.pdf حسب Huiyi Hu (11226995)

    منشور في 2025
    "…Moreover, survival analysis revealed the prognostic significance of this four-gene signature: high TOP2A with low ABLIM1, FHL5, and MAP3K8 expression correlated with decreased overall survival in ULMS, implicating their potential role as diagnostic and prognostic markers. …"
  14. 18294

    Table 1_Therapeutic potential of Triptolide in inhibiting breast cancer-induced bone destruction – PTHrP as a therapeutic target.docx حسب Wu Di (11561998)

    منشور في 2025
    "…Introduction<p>Bone metastases are a common and severe complication in advanced breast cancer, affecting approximately 65% to 70% of patients and significantly reducing survival time. Osteolytic bone metastases, in particular, are challenging to manage due to their association with skeletal-related events (SREs) that accelerate disease progression and diminish the quality of life. …"
  15. 18295

    HK2 regulates mRNA translation in melanoma cells. حسب Ana Luisa Dian (22258504)

    منشور في 2025
    "…HK2 depletion significantly decreased the abundance of <i>SOX10</i>, <i>CDH2</i>, and <i>WNT5A</i> mRNAs extracted from polysome fractions, but not in total RNAs. …"
  16. 18296

    VB2 cell fate analysis of <i>hlh-17</i>, <i>hlh-31</i>, and <i>hlh-32</i> mutant animals. حسب G. Robert Aguilar (13889674)

    منشور في 2025
    "…(<b>B</b>) In <i>hlh-17/31/32</i><sup>null</sup> mutants, <i>flp-32(syb4374)</i> reporter allele expression in VB2 is decreased, reaching the same level of expression as that in VB1. …"
  17. 18297

    Data Sheet 1_Characterization of the Vibrio anguillarum VaRyhB regulon and role in pathogenesis.docx حسب Yingjie Li (2106778)

    منشور في 2025
    "…The virulence of VaRyhB was evaluated by challenging turbot larvae intraperitoneally. </p>Results<p>The small RNA called VaRyhB identified in V. anguillarum strain 775 is significantly longer than that in Escherichia coli. …"
  18. 18298

    Table 2_Cornuside mitigates acute lung injury through suppression of NLRP3 inflammasome-mediated pyroptosis and activation of the Keap1-Nrf2 antioxidant response.xlsx حسب Tong Luo (458639)

    منشور في 2025
    "…</p>Results<p>CNS significantly improved survival, reduced pulmonary edema, and alleviated lung inflammation and locomotor deficits in LPS-challenged mice. …"
  19. 18299

    Table 1_Cornuside mitigates acute lung injury through suppression of NLRP3 inflammasome-mediated pyroptosis and activation of the Keap1-Nrf2 antioxidant response.xlsx حسب Tong Luo (458639)

    منشور في 2025
    "…</p>Results<p>CNS significantly improved survival, reduced pulmonary edema, and alleviated lung inflammation and locomotor deficits in LPS-challenged mice. …"
  20. 18300

    <b>Combination of isobavachalcone and amphotericin B has antifungal effect against </b><b>Cryptococcus neoformans</b><b>and protects host tissue damage by inhibiting ferroptosis</b... حسب Weidong Qian (20813608)

    منشور في 2025
    "…The development of novel therapeutic strategies is imperative, albeit challenging. A promising approach involves the synergistic interaction between existing antifungal agents and supplements to enhance efficacy, reduce dosages, and mitigate resistance. …"