Thymoquinone from Nigella sativa seeds promotes the antitumor activity of noncytotoxic doses of topotecan in human colorectal cancer cells in vitro حسب Khalife, Rana

"…The reduction in proliferation was significantly dose- and time-dependent. After determining the best combination (40 µM thymoquinone and 0.6 µM topotecan), cell proteins were extracted after treatment, and the expression levels of B-cell lymphoma 2 and of its associated X protein, proteins p53 and p21, and caspase-9, caspase-3, and caspase-8 were studied by Western blot. …"
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Using XAI Techniques to Detect Targeted Data Poisoning Attacks on Healthcare Applications of Machine Learning Systems حسب Eyad Dhaher Megdadi

"…We propose a method of monitoring the impact level of carefully chosen features as an indicator of potential poisoning, using predetermined thresholds to trigger warnings when unusual patterns are detected. …"
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16S rRNA Gene-Based Characterization and Functional Profiling of the Microbiome in Young Adults حسب Makhlouf, Rita

"…The high observed Firmicutes to Bacteroidetes ratio and the dominance of Bacteroides over Prevotella are associated with a diet rich in fat and proteins. An increased Proteobacteria level was linked with gut dysbiosis and reported in Type 2 diabetes, metabolic disorders, and Inflammatory Bowel Disease (IBD). …"
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Numerical investigation of design strategies to achieve perpetual pavements حسب Abou-Jaoude, Grace

"…Such methods are based on the idea of reducing the tensile strain at the bottom of the HMA layer below the Fatigue Endurance Limit (FEL), a level of strain below which no cumulative damage occurs to the HMA mixture. …"
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Cytokine-Mediated Dysregulation of Signaling Pathways in the Pathogenesis of Multiple Myeloma حسب Sabah Akhtar (5809925)

"…The imbalance between inflammatory and anti-inflammatory cytokines in MM leads to an increased level of pro-inflammatory cytokines, which in turn play a significant role in dysregulation of signaling pathways and proliferation of MM cells; however, the association appears to be inadequate and needs more research. …"

Frugal innovation for sustainable rural development حسب Mokter Hossain (14634969)

"…However, certain SDGs have limited potential for frugal or other types of innovation to make significant contributions, as these goals are mainly intended to be assessed at the national level. …"

TCAD Simulation and Analysis of Selective Buried Oxide MOSFET Dynamic Power حسب Mahmoud, Rana

"…This power difference becomes significant at the chip level. For instance, at 1 MHz, SOI and SELBOX exhibit an average dynamic power consumption of 0.0026 μWless than that of the BULK structure. …"
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The Stakeholders’ Perceptions about the Effectiveness of iPads Integrations in Third Grade English Classes in a Private School in Sharjah, UAE حسب AL-HUSSAINI, OLA SALEH HUSSAIN

"…The analysis revealed that parents and teachers have neutral attitude toward the use of iPads, they believe that iPads are important for students learning but not for this specific grade level as it has negative effect on students’ fundamental skills. …"
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Enhancing Thermal Comfort in Urban Communities with Urban Configurations and Green Coverage: A Case Study of Dubai Sustainable City حسب MUAILEQ, LAMA SULIMAN ABU

"…Moreover, courtyard design impacts air distribution and air temperature, which is connected to predicted mean vote values, and green coverage percentage in the courtyard impacts microclimate variables, as it reduces air temperature by increasing relative humidity to a moderate level. Finally, all previous enhancements applied to the outdoor thermal comfort variable affects the indoor total energy consumption, as it reduces the energy load needed to mitigate the outdoor environment.…"
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Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer In vitro حسب Najem, Sonia A.

"…Furthermore, the combination therapy upregulates protein expression levels of pro-apoptotic proteins Bax, p53 and cytochrome c, downregulates the expression of antiapoptotic Bcl-2 protein and increases the cleavage of procaspases 8 and 9; this suggests that the combination activates apoptosis via both the intrinsic and extrinsic pathways. …"
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Airflow dynamics in an emergency department: A CFD simulation study to analyse COVID-19 dispersion حسب Odi Fawwaz Alrebi (19499188)

"…The analysis revealed that three critical areas of the emergency department, namely overnight patient beds, operating rooms, and resuscitation rooms, had significantly higher air velocity, dispersion, and mixing levels than the rest of the department's spaces. …"

Assessment of Disinfection By-Product Formation in Polymeric Pipe Distribution Systems حسب Shabani, Sina

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Positional and dimensional temporomandibular joint osseous changes in patients treated with the forsus fatigue resistant device: a non-randomized clinical trial حسب Ramy Abdul-Rahman Ishaq (22928974)

"…In the treatment group, condylar width decreased significantly by 0.52 ± 0.92 mm, in contrast to an increase of 0.17 ± 0.35 mm in the control group (<i>P</i> = 0.010). …"

Circulating and Tumor-Infiltrating Immune Checkpoint-Expressing CD8+ Treg/T Cell Subsets and Their Associations with Disease-Free Survival in Colorectal Cancer Patients حسب Alhasan Alsalman (14802873)

"…We found that FoxP3 expression and ICs including PD-1, CTLA-4, TIM-3, and LAG-3 were significantly increased in tumor-infiltrating CD8+ T cells compared with NT and peripheral blood. …"

Global, regional and national burden of bladder cancer and its attributable risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of... حسب Saeid Safiri (3713035)

"…<h3>Introduction</h3><p dir="ltr">The current study determined the level and trends associated with the incidence, death and disability rates for bladder cancer and its attributable risk factors in 204 countries and territories, from 1990 to 2019, by age, sex and sociodemographic index (SDI; a composite measure of sociodemographic factors).…"

Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice حسب Ayman, Alzu'bi

"…These findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (BDNF), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. …"
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Retinal nerve fiber layer and macular thickness in amblyopia as measured by spectral domain optical coherence tomography حسب Al-Haddad, Christiane E.

"…The mean macular thickness was significantly increased in the amblyopic (273.8 μm) vs fellow eyes (257.9 μm), p=0.001. …"
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Space size relative to prey width and total cover in an area both influence the habitat choices of freshwater angelfish Pterophyllum scalare in mesocosms حسب Bartholomew, Aaron

"…Hypotheses predict that prey survivorship is maximized at intermediate Sp/Py values and that prey survivorship increases rapidly from zero to low cover but increases at a slower rate as cover increases further. …"
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Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice حسب Ayman Alzu'bi (18192898)

"…These findings were found to be correlated with increased level of <u>oxidative stress, neuroinflammation,</u> and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (BDNF), which plays an essential role in modulating <u>synaptic plasticity</u> integral for promoting learning and memory in the hippocampus. …"

A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report حسب Mohamed Kamal Sabra (17075230)

"…On examination, he had jaundice, bilateral exophthalmos, diffuse goiter, ascites, and significant lower limb edema. Laboratory investigations showed increased Thyroxin level with a suppressed thyroid stimulating hormone and positive anti‐thyrotropin receptor antibodies. …"