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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Shared decision making with black patients: A scoping review
Published 2023“…</p><h3><br></h3><h3>Practice implications</h3><p dir="ltr"><br></p><p dir="ltr">Shared decision making (SDM) has been proposed as a useful tool for improving quality and equity in Black patients’ care. …”
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AI-assisted decision-making in mild traumatic brain injury
Published 2025“…<h3>Objective</h3><p dir="ltr">This study evaluates the potential use of ChatGPT in aiding clinical decision-making for patients with mild traumatic brain injury (TBI) by assessing the quality of responses it generates for clinical care.…”
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Curricular integration of the pharmacists' patient care process
Published 2021“…Results The findings indicate that the PPCP-based laboratory significantly improved students' perception of their preparedness to apply a standardized pharmacist care process to verify prescriptions, to collect relevant patient information, and to develop an individual patient-centered care plan. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Pharmacy Students’ Clinical Reasoning and Decision-Making to Detect and Resolve Medication Errors
Published 2025“…<h3>Objective</h3><p dir="ltr">Medication errors pose a significant challenge in health care, impacting patient safety. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Generative artificial intelligence (GenAI) and decision-making: Legal & ethical hurdles for implementation in mental health
Published 2024“…<p>This article argues that significant risks are being taken with using GenAI in mental health that should be assessed urgently. …”
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Systematic analysis of healthcare big data analytics for efficient care and disease diagnosing
Published 2022“…It contains a gigantic amount of data, especially a plethora of data types that has been significantly useful in diverse research domains. In healthcare domain, the researchers use computational devices to extract enriched relevant information from this data and develop smart applications to solve real-life problems in a timely fashion. …”
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Using Mobile Technology for Coordinating Educational Plans and Supporting Decision Making Through Reinforcement Learning in Inclusive Settings
Published 2021“…Learners with special education needs and disabilities (SEND) require attention from a large set of a care team that includes parents, teachers, specialists, therapists, and doctors. …”
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