Supplementary file 1_Pedunculoside targets P2X7R to protect against myocarditis by regulating the NLRP3/PIP2/MAPK signaling pathway.docx حسب Youqiong Zhuo (10361585)

"…</p>Results<p>We found that PE demonstrated inhibition of H9c2 cell death and decreased ROS, Ca²⁺ levels, and MMP loss induced by LPS + ATP. …"

Image 1_sodA modulates in vitro and in vivo virulence of Yersinia enterocolitica.jpeg حسب Yingying Zhang (42910)

"…</p>Results<p>The ΔsodA mutant exhibited significantly reduced adhesion to and invasion of epithelial cells, impaired survival within macrophages, and decreased colonization in murine ileum and colon tissues. …"

<b>RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy</b> حسب Hongmei Qian (538647)

"…</p><p><br></p><p dir="ltr"><b>Results:</b> In glaucomatous mice, RTA408 significantly reduces the apoptosis levels of RGCs and decreases RGC loss. …"

Table 1_Adherence to recombinant human growth hormone therapy in children: influencing factors and clinical implications.xlsx حسب Wenjing Chang (8334480)

"…However, non-adherence remains a significant challenge, affecting treatment efficacy and patient prognosis. …"

Image 2_Phage (cocktail)-antibiotic synergism: a new frontier in addressing Klebsiella pneumoniae resistance.tif حسب Chandrasekar Karthika (21255878)

"…In vitro investigations demonstrated that the phage cocktail significantly decreased both planktonic and sessile cells. …"

Table 1_Salt tolerance characterization and genome-wide association study of Gossypium barbadense accessions reveal salinity-adaptive variations.xlsx حسب Huazu Li (22228792)

"…VIGS of GbXTH27 exacerbated salt-induced wilting phenotypes and significantly decreased antioxidant enzyme activities.…"

Supplementary file 2_Global burden of pulmonary sarcoidosis from 1990 to 2021: a comprehensive analysis based on the GBD 2021 study.xlsx حسب Jinming Cao (7837883)

"…</p>Results<p>In 2021, global incidence cases reached 390,000, with 43.07 million prevalence cases, 1.88 million deaths and 40.42 million DALYs. Despite decreases in ASR since 1990, absolute numbers rose. …"

Table3_Dynamics of flavonoid metabolites in coconut water based on metabolomics perspective.xlsx حسب Mingming Hou (11341656)

"…The total flavonoid content in both types of coconut water exhibited a decreasing trend with developmental progression, but the total flavonoid content in CK was significantly higher than that in W5. …"

<b><i>Assessment of Diseases’ Prevalence, Nutrition and Associated Factors in a Conflict-Affected Region: A Study in Leepa Valley, Azad Jammu and Kashmir, Pakistan</i></b> حسب Zoha Khan (19100603)

"…Moreover, 76.3% reported decreased employment opportunities in Leepa Valley due to the ongoing border conflicts. …"

Table 1_Biofilm formation and role of other pathogenic factors in the virulence of Staphylococcus epidermidis clinical isolates.docx حسب María Coronada Fernández-Calderón (21993110)

"…The primary virulence factor of S. epidermidis is biofilm formation, which decreases antibiotic efficacy and host immune response. …"

Table 1_Pachymic acid alleviates metabolic dysfunction-associated steatotic liver disease by inhibiting ferroptosis through PPARα.xlsx حسب Guilin Ren (18720749)

"…</p>Results<p>HFD induced biochemical abnormalities and liver injury, which were significantly reversed by Pac, as evidenced by decreased plasma levels of AST (Aspartate aminotransferase), ALT (Alanine aminotransferase), TG (Triglyceride), and TC (Total cholesterol), and reduced hepatic TG and TC levels. …"

Data_Sheet_1_Global burden of multiple sclerosis and its attributable risk factors, 1990–2019.PDF حسب Saeid Safiri (3713035)

"…</p>Conclusion<p>Although the global age-standardized DALY rate of MS decreased between 1990 and 2019, MS continues to account for a considerable number of DALYs and prevalent cases. …"

Table 1_In vivo profiling of the PE/PPE proteins of Mycobacterium tuberculosis reveals diverse contributions to virulence.xlsx حسب Benjamin Koleske (11581641)

"…We found consistent, time-dependent changes in mutant abundance across our animal replicates and identified decreases in several key mutant strains known to promote bacterial growth or virulence. …"

Image 1_Salt tolerance characterization and genome-wide association study of Gossypium barbadense accessions reveal salinity-adaptive variations.jpeg حسب Huazu Li (22228792)

"…VIGS of GbXTH27 exacerbated salt-induced wilting phenotypes and significantly decreased antioxidant enzyme activities.…"

Table 7_Transcriptome and metabolome profiling reveal the chlorogenic acid as a resistance substance for rice against the white-backed planthopper Sogatella furcifera (Horváth).xls... حسب Wenqi Xie (5903936)

"…Exogenous application of CGA to TN1 enhanced its tolerance and antixenosis to WBPH, significantly decreasing WBPH’s survival and mean dry weight. …"

Table 4_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden... حسب Jiaoli Xu (20871584)

"…</p>Results<p>We report a 55.34% reduction in CHD-related deaths among children, with global mortality rates decreasing from 28.63 per 100,000 in 1990 to 11.06 per 100,000 in 2021. …"

Supplementary file 1_Monitoring the dual-season hydrological dynamics of the Pong reservoir in Himachal Pradesh, India.docx حسب Rajesh Sarda (13162317)

"…The study employed a spatial linear trend modelling approach to identify trends in relative water depth, revealing a decreasing trend and a quantifiable reduction in the reservoir’s depth for both seasons. …"

Table 3_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden... حسب Jiaoli Xu (20871584)

"…</p>Results<p>We report a 55.34% reduction in CHD-related deaths among children, with global mortality rates decreasing from 28.63 per 100,000 in 1990 to 11.06 per 100,000 in 2021. …"

Table 3_Nutritional and inflammatory biomarkers in predicting spontaneous anastomotic leakage closure following enterocutaneous fistula resection: the role of postoperative CRP-lym... حسب Tianchi Yu (3335091)

"…Notably, the resolution rate was considerably lower in patients whose ECF was attributable to pancreatitis, with an OR of 0.21 (p = 0.02) relative to other causes.</p>Conclusion<p>Decreasing CLR subsequent to leakage may be one of supportive predictor for spontaneous closure of AL following ECF resection.…"

Table 1_Specific inhibition of glutamine synthase involved in the metabolic pathway of amino acids is associated with anti-arthritic effects of sinomenine hydrochloride.docx حسب Gejing Li (18948236)

"…Experimental validation confirmed that SH (50–200 μM) significantly inhibited GS activity and GLUL expression and consequently decreased glutamine levels in RA-FLS. …"