This file includes a supplementary figure relevant to the main body of the manuscript. by Aahan Arif (20189512)

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This file includes a supplementary figure relevant to the main body of the manuscript. by Aahan Arif (20189512)

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This file includes a supplementary figure relevant to the main body of the manuscript. by Aahan Arif (20189512)

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This file includes a supplementary figure relevant to the main body of the manuscript. by Aahan Arif (20189512)

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This file includes a supplementary figure relevant to the main body of the manuscript. by Aahan Arif (20189512)

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(A) O2PLS−Scores scatter diagram; (B) Integrated analysis of the top 20 KEGG pathways. by Bingshuo Shi (21485387)

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Human <i>CTSZ</i> variants are associated with TB severity, and CTSZ is present at the host-pathogen interface within human pulmonary <i>Mtb</i> granulomas. by Rachel K. Meade (22216529)

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Identification and validation of <i>Ctsz</i> as the lead candidate gene underlying <i>Tip5.</i> by Rachel K. Meade (22216529)

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IRE1 depletion induces cell cycle arrest independently of apoptosis. by Iratxe Zuazo-Gaztelu (21071939)

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Original raw data used to generate graphs in Figs 1–6 and S1–S6 Fig. by Iratxe Zuazo-Gaztelu (21071939)

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IRE1 silencing downregulates cell cycle genes and engages TP53 and specific CDK inhibitors. by Iratxe Zuazo-Gaztelu (21071939)

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Experimental design. by Xueyan Lin (448667)

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Endogenous IRE1 protein can localize to the nuclear envelope. by Iratxe Zuazo-Gaztelu (21071939)

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<i>Ctsz</i>^{<i>−/−</i>} mice have higher lung burden and earlier spleen dissemination during acute infection followed by greater chronic inflammation and mortality risk.... by Rachel K. Meade (22216529)

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IRE1 silencing downregulates cell cycle genes and engages TP53 and specific CDK inhibitors. by Iratxe Zuazo-Gaztelu (21071939)

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Cathepsin Z is highly expressed in macrophages across species following mycobacterial infection and mediates levels of CXCL1 in murine macrophages. by Rachel K. Meade (22216529)

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IRE1 depletion downregulates multiple cell cycle proteins in synchronized cells. by Iratxe Zuazo-Gaztelu (21071939)

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IRE1 depletion downregulates multiple cell cycle proteins in synchronized cells. by Iratxe Zuazo-Gaztelu (21071939)

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Fig 1B raw image. by Rachel K. Meade (22216529)

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Complete list of 81 <i>CTSZ</i> SNPs present in Ugandan household contact study cohorts and their associations with TB severity. by Rachel K. Meade (22216529)

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