Image 1_Quantitative analysis of targeted lipidomics in the hippocampus of APP/PS1 mice employing the UHPLC-MS/MS method.jpeg by Shiyu Xiao (8147688)

“…Furthermore, hexosylceramides (HexCers) and ceramides (Cers) in the AD model’s hippocampus, the prominent sphingolipids in the hippocampus of AD mice, existed as the two primary changed lipid metabolites. The levels of some TGs in GLs and CEs in STs showed a significant elevation (p < 0.05, VIP > 1). …”

Image 2_Quantitative analysis of targeted lipidomics in the hippocampus of APP/PS1 mice employing the UHPLC-MS/MS method.jpeg by Shiyu Xiao (8147688)

“…Furthermore, hexosylceramides (HexCers) and ceramides (Cers) in the AD model’s hippocampus, the prominent sphingolipids in the hippocampus of AD mice, existed as the two primary changed lipid metabolites. The levels of some TGs in GLs and CEs in STs showed a significant elevation (p < 0.05, VIP > 1). …”

Data Sheet 1_Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway.pdf by figshare admin frontiersin (4545187)

“…Combining network pharmacology prediction analysis with our validation data from animal models and colonic organoids, we demonstrated that Cyn significantly inhibits IEC apoptosis, as indicated by a decrease in the proportion of TUNEL-positive cells and changes in apoptosis-related protein levels. …”

DataSheet1_Clerodendranthus spicatus [Orthosiphon aristatus (Blume) Miq.] maintains uric acid homeostasis via regulating gut microbiota and restrains renal inflammation in hyperuri... by Yang Wang (5921)

“…Also known as C. spicatus, which has a significant therapeutic effect on hyperuricemia nephropathy (HN), however, the specific mechanism of its action is still unknown.…”

<b>Microplastic and drought influence the positive effect of plant diversity on plant biomass production</b> by Jing Man (22181824)

“…By contrast, drought significantly weakened this positive relationship by inducing a negative complementarity effect that led to a negative net diversity effect through strongly reduced shoot biomass of legumes. …”

Betti curves of CD4(+) T cells, B220(+) DN T cells and megakaryocytes populations in the murine spleen tissue. by Maria Torras-Pérez (22439376)

“…For this cell type, the total cell counts do not change significantly between health and disease (Welch t-test p-value is 0.16). …”

Strategy parameters across development for female mice in set size = 2 and set size = 4 from winning computational model. by Juliana Chase (20469427)

“…However, female mice had a significant decrease in parameter S1 “Inappropriate Lose-Shift” in set size = 4 (H: <i>p</i> = 0.04) with a trend in a similar direction in set size = 2 (C: <i>p</i> = 0.08).…”

Table 1_Food waste management practices in hospital foodservices and their associated greenhouse gas emissions: potential for increased environmental sustainability.docx by Yee Man Janis Yip (21346568)

“…There was a statistically significant median reduction in GHGs when changing from landfill to donations (−11.54, p < 0.001), landfill to industrial uses (−25.92, p < 0.001), and landfill to composting (−15.24, p < 0.001). …”

Image 1_Emphysema-related mortality rates in the U.S. from 1999 to 2022.pdf by Alexandra Brown (225908)

“…</p>Discussion<p>Emphysema-related deaths in the United States decreased overall between 1999 and 2022, likely a result of a greater emphasis on health education concerning the significant dangers of smoking and policy changes that made cigarettes less accessible and less affordable, and more available access to resources and support networks.…”

Supplementary file 1_Patterns in (es)citalopram prescriptions to Medicaid and Medicare patients in the United States: the potential effects of evergreening.docx by Luke R. Cavanah (19022435)

“…We hypothesized that prescription rates of citalopram will decrease with a concurrent increase in escitalopram, consistent with “evergreening”.…”

Data Sheet 1_Non-stationary response of Pacific saury (Cololabis saira) in the northwestern Pacific to climate variability.docx by Chang Cao (2592700)

“…The dynamics of Pacific saury from 1970 to 2021 could be divided into four periods: the 1970s and 1980s when the Siberian High and the intensification of the East Asian winter monsoon drove down the water temperature, providing a suitable habitat and resulting in an increase in resource abundance; In the 1990s, the rise in temperature led to a reduction in resource abundance; At the beginning of the 21st century, the enhancement of the Siberian High brought about a suitable habitat, and the resource abundance showed a significant increase; The unfavorable high water temperature environment in the 2010s caused the resource abundance to decrease once again. …”

Figure S5 from Immunoproteasome Activation Expands the MHC Class I Immunopeptidome, Unmasks Neoantigens, and Enhances T-cell Anti-Myeloma Activity by Priyanka S. Rana (15136410)

“…Compound A induced a marked decrease in PD-1 surface expression, while no significant change was observed in TIM-3, CTLA-4, and LAG-3.…”

Data Sheet 1_The role of intestinal homeostasis in sevoflurane-induced myelin development and cognitive impairment in neonatal mice.docx by Chang Liu (35901)

“…</p>Results<p>After repeated exposure to sevoflurane, neonatal mice developed persistent gut microbiota imbalance accompanied by a decrease in short-chain fatty acids. Short-term intestinal inflammation emerged, with damage to the mucus layer and barrier function. …”

Table 1_Opposing effects of sugar-free claims on perceived healthiness and sweetness reduce consumers’ willingness to pay for sugar-free products.docx by Ksenia Panidi (5991186)

“…However, this positive effect was overridden by a significant decrease in perceived tastiness and sweetness of products labeled as sugar-free compared to sugar-containing ones, which in turn led to a reduction in the willingness to pay. …”

Table 1_Effectiveness of conversational script optimization by intelligent consultation robots on daily work efficiency in vaccination clinics.docx by Bei Zhou (5219792)

“…</p>Results<p>As the scripts evolved, there was a notable increase in automated response rates and a decrease in human support transfers. …”

Ydj1 acetylation alters interactions with client proteins. by Siddhi Omkar (12413434)

“…Interactors are colored according to change in interaction as follows: green (significant increase), red (significant decrease), or purple (no significant change) 6KQ/6KR. …”

Datasheet1_Analysis of blood metabolite characteristics at birth in preterm infants with bronchopulmonary dysplasia: an observational cohort study.pdf by Yanping Guo (2467576)

“…To control for GA differences, we conducted a subgroup analysis. In the GA 24⁺⁴–27⁺⁶ weeks subgroup, we observed a significant decrease in histidine levels and the ornithine/citrulline ratio in the BPD group. …”

Data Sheet 1_Epidemiological trends and age-period-cohort effects on subarachnoid hemorrhage burden across the BRICS-plus from 1992 to 2021.docx by Liang Guo (95092)

“…A significant negative correlation was observed between the incidence rate of SAH and SDI values. …”

The ADMET analysis of the selected compounds. by Ali Alisaac (14658440)

“…RMSF analysis indicated greater flexibility in ligand-binding regions of LasI-Sulfaperin and QscR complexes, suggesting weaker binding. SASA showed a decrease in solvent-accessible surface area for the LasI-Sulfamerazine complex, supporting a compact structure. …”

AMDET profiling parameters and shorting criteria. by Ali Alisaac (14658440)

“…RMSF analysis indicated greater flexibility in ligand-binding regions of LasI-Sulfaperin and QscR complexes, suggesting weaker binding. SASA showed a decrease in solvent-accessible surface area for the LasI-Sulfamerazine complex, supporting a compact structure. …”