Image1_MAP3K1 Variant Causes Hyperactivation of Wnt4/β-Catenin/FOXL2 Signaling Contributing to 46,XY Disorders/Differences of Sex Development.TIF by Hong Chen (108084)

“…Functional assays demonstrated that the MAP3K1^R186G variant was associated with significantly decreased affinity to ubiquitin (Ub; 43–49%) and increased affinity to RhoA, which was 3.19 ± 0.18 fold, compared to MAP3K1. …”

Image2_MAP3K1 Variant Causes Hyperactivation of Wnt4/β-Catenin/FOXL2 Signaling Contributing to 46,XY Disorders/Differences of Sex Development.TIF by Hong Chen (108084)

“…Functional assays demonstrated that the MAP3K1^R186G variant was associated with significantly decreased affinity to ubiquitin (Ub; 43–49%) and increased affinity to RhoA, which was 3.19 ± 0.18 fold, compared to MAP3K1. …”

Image5_MAP3K1 Variant Causes Hyperactivation of Wnt4/β-Catenin/FOXL2 Signaling Contributing to 46,XY Disorders/Differences of Sex Development.TIF by Hong Chen (108084)

“…Functional assays demonstrated that the MAP3K1^R186G variant was associated with significantly decreased affinity to ubiquitin (Ub; 43–49%) and increased affinity to RhoA, which was 3.19 ± 0.18 fold, compared to MAP3K1. …”

Table_1_Tumor Growth in the High Frequency Medulloblastoma Mouse Model Ptch1+/−/Tis21KO Has a Specific Activation Signature of the PI3K/AKT/mTOR Pathway and Is Counteracted by the... by Manuela Ceccarelli (4398151)

“…Additionally, the phosphorylation of AKT, S6 and 4EBP1 was significantly inhibited, indicating inactivation of the PI3K/AKT/mTOR pathway. …”

<i>daf-16</i> is required to prevent precocious adoption of adult cell fate during dauer. by Matthew J. Wirick (11708043)

“…These collagens were expressed at significantly different levels (FDR ≤ 0.05) in <i>daf-16(0)</i> vs control dauer larvae in all cases except those collagens indicated by †. …”

<i>headcase</i> affects the physiology of the prothoracic gland and the release of ecdysone. by Panagiotis Giannios (10113763)

“…(D) Relative expression levels for the mRNAs of the ecdysone targets <i>Hr3</i>, <i>Hr4</i> and <i>Br-C</i> in total larval extracts appear significantly decreased in <i>phmGal4/hdc</i>^<i>RI</i> larvae compared to control <i>phmGal4/+ larvae</i> (alpha set at <i>0</i>.…”

The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis by Shulan Pi (8562315)

“…Genetic knockdown of the essential autophagy gene <i>Atg5</i> significantly attenuated P2RY12 receptor inhibitor-induced cholesterol efflux in VSMCs. …”

LRIG1 and CDK6 expression in the lateral ventricular wall cells by Hyung-song Nam (8914220)

“…Although the <i>Cdk6</i> mRNA decreases significantly in the neuroblasts, the DCX+ neuroblasts still show a lot of td-sfGFP immunoreactivity.…”