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significant advances » significant advantages (Expand Search), significantly advanced (Expand Search), significant advancements (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
advances decrease » advanced disease (Expand Search), advanced defense (Expand Search)
significant advances » significant advantages (Expand Search), significantly advanced (Expand Search), significant advancements (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
advances decrease » advanced disease (Expand Search), advanced defense (Expand Search)
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19781
Design, synthesis and biological evaluation of marine naphthoquinone-naphthol derivatives as potential anticancer agents
Published 2024“…Further mechanistic studies revealed that compound <b>13</b> significantly induced cell apoptosis by increasing the expression levels of cleaved caspase-3 and reducing Bcl-2 proteins through downregulating the EGFR/PI3K/Akt signalling pathway, leading to the inhibition of proliferation in HCT116 and PC9 cells. …”
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19782
Supplementary Material for: A common variant in NID1 gene associated with the prognosis of heart failure
Published 2025“…Western blot analysis demonstrated that the protein level of NID1 was significantly higher in the rs3738530-T allele compared to the A allele (P < 0.05). …”
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19783
Data Sheet 1_GPER1 signaling restricts macrophage proliferation and accumulation in human hepatocellular carcinoma.pdf
Published 2024“…The expression of G protein–coupled estrogen receptor 1 (GPER1), a non-classical estrogen receptor, was significantly decreased in proliferating macrophages, and was inversely correlated with macrophage proliferation in HCC tumors. …”
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19784
Data Sheet 12_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.pdf
Published 2025“…We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”
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19785
Dust particle flow trace diagram.
Published 2025“…Results indicate that installing a return pipe significantly reduces dust overflow caused by impact airflow during blanking. …”
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19786
Adverse events in patients with castration-resistant prostate cancer treated with ra-223: a retrospective pharmacovigilance study
Published 2024“…Four sequential analysis strategies were employed to assess the significance of these AEs.</p> <p>In total, 4,228 Ra-223-related AE reports were identified in the FAERS database. …”
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19787
Model inputs.
Published 2024“…Clinical findings have showed that deprescribing service significantly decreased inappropriate PPIs utilization. …”
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19788
Image 5_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.tif
Published 2025“…Wheat seed inoculation significantly enhanced germination metrics, seedling vigor, and altered carbohydrate metabolism in the seed endosperm. …”
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19789
Discrete phase parameter setting.
Published 2025“…Results indicate that installing a return pipe significantly reduces dust overflow caused by impact airflow during blanking. …”
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19790
Data Sheet 3_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.csv
Published 2025“…We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”
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19791
Table 1_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le...
Published 2025“…Furthermore, 29 out of 47 differential metabolites significantly correlated with the eight dominant microbial genera. …”
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19792
Table 1_Case report: Treatment of severe phorate poisoning.xlsx
Published 2025“…In the follow-up treatment, the concentration of five metabolites gradually decreased. The concentration of the phorate sulfoxide and phorate sulfone rebounded with the suspension of HP, but that of the other metabolites did not rebound. …”
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19793
Bgh/GelMA/CMCS hydrogel with bone MSC-EVs for lunate defect repair
Published 2025“…In vivo, the M1/M2 ratio and inflammatory factors decreased significantly one-week post-implantation, while CD31 and VEGF-positive cells increased at four weeks, and BMP2 and OPN-positive cells at eight weeks. …”
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19794
Disruption of Astrocyte Communication by Carbenoxolone During Shockwave-Induced Stress
Published 2025“…Peak calcium intensity was significantly reduced at 100 µM CBX, and both rise and fall rates of calcium signals decreased with increasing CBX concentration. …”
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19795
Supplementary file 1_Metabolic insights into hypoxia adaptation in adolescent athletes at different altitudes: a cross-sectional study.docx
Published 2025“…Lipid metabolism was significantly altered in moderate-altitude athletes, including pathways such as linolenic and linoleic acid, sphingolipid, and arachidonic acid, as well as processes involving the transfer of acetyl groups into mitochondria and fatty acid biosynthesis. …”
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19796
Table 1_Study on the effect of different types of sugar on proliferation and inflammatory in goose fatty liver.docx
Published 2025“…Glucose combined with si-CPT1A treatment decreased CyclinD3 while increasing p21 expression. …”
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19797
Image 2_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.tif
Published 2025“…Wheat seed inoculation significantly enhanced germination metrics, seedling vigor, and altered carbohydrate metabolism in the seed endosperm. …”
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19798
Image 2_Modulation of VR-HMD-induced cybersickness using cathodal transcranial direct current stimulation: a functional near-infrared spectroscopy study.jpeg
Published 2025“…Results showed that cathodal tDCS significantly reduced nausea-related cybersickness symptoms compared to sham stimulation (p < 0.05). fNIRS analysis revealed decreased oxyhemoglobin concentrations in the bilateral superior parietal lobule and angular gyrus following cathodal tDCS, indicating reduced cortical activity in these regions. …”
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19799
The structure of IRAU and Res2Net+ block [22].
Published 2025“…However, after removing the integrated residual attention unit and depth-wise separable convolution, the accuracy decreased by 1.91% and the latency increased by 117ms. …”
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19800
Table 1_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.xlsx
Published 2025“…Wheat seed inoculation significantly enhanced germination metrics, seedling vigor, and altered carbohydrate metabolism in the seed endosperm. …”