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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Health-related quality of life and its predictors among adults living with HIV/AIDS and receiving antiretroviral therapy in Pakistan
منشور في 2022"…<h2>Background</h2> <p>Health-related quality of life (HRQoL) is considered to be the fourth 90 of UNAIDS 90-90-90 target to monitor the effects of combination antiretroviral therapy (ART). ART has significantly increased the life expectancy of people living with HIV/AIDS (PLWHA). …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Qatari national scholarships: University selectivity and student outcomes
منشور في 2015"…<p dir="ltr">The scholarship program in Qatar provides aid for students wishing to enroll in “top-ranked” universities around the world by supplying them with tuition, fees, board, and travel. …"
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Effect of community-based intervention on knowledge and practice of rural mothers toward children home injuries
منشور في 2023"…Rural mothers require effective community-based intervention programs to achieve appropriate levels of awareness and practices regarding these unintentional home injuries. …"
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NOVEL STACKING CLASSIFICATION AND PREDICTION ALGORITHM BASED AMBIENT ASSISTED LIVING FOR ELDERLY
منشور في 2022"…Therefore, this thesis proposed a Novel Stacking Classification and Prediction (NSCP) algorithm based on AAL for the older people with Multi-strategy Combination based Feature Selection (MCFS) and Novel Clustering Aggregation (NCA) algorithms. …"
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A comprehensive review on harvesting of microalgae using Polyacrylamide-Based Flocculants: Potentials and challenges
منشور في 2021"…For the first time, a comprehensive evaluation of existing harvesting studies for freshwater and marine microalgae species using polyacrylamide-based flocculants was conducted. The impact of polyacrylamide-based flocculant characteristics (e.g., charge type, charge density, polymer architecture, molecular weight) on flocculation efficiencies was examined. …"
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A novel spherical fuzzy-based decision model for assessing data management maturity in governmental institutions
منشور في 2025"…The criteria were subjectively weighted by an expert panel (SME) to reflect the significance of each criterion in a government setting. …"
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Prioritizing factors for the adoption of IoT-based smart irrigation in Saudi Arabia: a GRA/AHP approach
منشور في 2024"…This study is focused on the identification of the factors and challenges through a systematic review and ranking of the challenges/factors that exert a significant influence on the adoption of I-SIMS. Ranking aids in determining the importance of various alternatives. …"
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Artificial intelligence based anomaly detection of energy consumption in buildings: A review, current trends and new perspectives
منشور في 2021"…Following, insights about current research trends are discussed to widen the applications and effectiveness of the anomaly detection technology before deriving future directions attracting significant attention. This article serves as a comprehensive reference to understand the current technological progress in anomaly detection of energy consumption based on artificial intelligence.…"
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Prostate-based biofluids for the detection of prostate cancer: A comparative study of the diagnostic performance of cell-sourced RNA biomarkers
منشور في 2016"…The aim of this study was to investigate if PEUW contained prostate-based material, evidenced by the presence of prostate specific antigen (PSA), and to evaluate the diagnostic performance of PEUW-based biomarkers. …"
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