Table 1_Integrated analysis of serum metabolomics and fecal microbiome in infants with necrotizing enterocolitis.docx by Zhi-ying Lin (12997350)

“…Serum metabolomics identified significantly decreased ornithine, DL-arginine, L-threonine, leucine, and D-proline in NEC-D versus non-NEC. …”

DataSheet3_Dysregulation of the 3β-hydroxysteroid dehydrogenase type 2 enzyme and steroid hormone biosynthesis in chronic kidney disease.xlsx by Yiyi Zuo (19945293)

“…</p>Results<p>Metabolic characteristics revealed significant shifts in CKD, with 61 metabolites increased and 65 metabolites decreased, highlighting the disruption in steroid hormone biosynthesis pathways influenced by HSD3B2. …”

Data Sheet 2_Featured intestinal microbiota associated with hepatocellular carcinoma in various liver disease states.docx by Xiu Sun (8539698)

“…In the CHB-HCC, CC-HCC, and DC-HCC groups, the abundance of Bacteroides, Prevotella, and Faecalibacterium gradually decreased, whereas Klebsiella, Haemophilus, and Streptococcus increased. …”

Table 6_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.xlsx by Tien Le (634791)

“…Crim1 encodes a type I transmembrane protein that is expressed at the cell membrane of lens epithelial and fiber cells at the stage of lens pit formation. Decreased Crim1 expression in the mouse reduced the number of lens epithelial cells and caused defective adhesion between lens epithelial cells and between the epithelial and fiber cells.…”

Image2_Causal association between matrix metalloproteinases and diabetic neuropathy: a two-sample Mendelian randomization study.tif by Chao Bai (4428472)

“…Objective<p>Diabetic neuropathy (DN), a common and debilitating complication of diabetes, significantly impairs the quality of life of affected individuals. …”

Table_2_Effect of probiotic supplementation combined with bismuth-containing quadruple therapy on gut microbiota during Helicobacter pylori eradication: a randomized, double-blind,... by Zhongxue Han (19855215)

“…After treatment, the GSRS score decreased significantly in the probiotic group (p = 0.039). …”

Implementation and clinical impact of an interdisciplinary tool to promote skin integrity after flap surgery in Veterans with spinal cord injury by Byron Eddy (6281057)

“…The one-year flap failure rate abruptly decreased from 40.5% (15/37) of the 2009–2012 surgeries to 7.7% (6/78) of the 2013–2019 surgeries (P < .0001). …”

Data Sheet 3_Global, regional, and national burden of musculoskeletal disorders, 1990–2021: an analysis of the global burden of disease study 2021 and forecast to 2035.pdf by Meizhi Liu (21898892)

“…Frontier analysis revealed significant gaps between current burdens and achievable benchmarks, particularly in high-SDI regions, while some low-SDI regions demonstrated effective management despite limited resources. …”

Data Sheet 10_Global, regional, and national burden of musculoskeletal disorders, 1990–2021: an analysis of the global burden of disease study 2021 and forecast to 2035.pdf by Meizhi Liu (21898892)

“…Frontier analysis revealed significant gaps between current burdens and achievable benchmarks, particularly in high-SDI regions, while some low-SDI regions demonstrated effective management despite limited resources. …”

Table 1_Unveiling the gut-heart potential connection: microbiota’s role in kawasaki disease and coronary artery lesions.docx by Qing Yang (67856)

“…Thirteen genera showed statistically significant changes, including Enterococcus, Bacteroides, Faecalibacterium, Agathobacter, Lachnospiraceae_NK4A136_group, Roseburia, Monoglobus, etc. …”

Table 1_Sitagliptin phosphate ameliorates chronic inflammation in diabetes mellitus via modulating macrophage polarization.docx by Xiaoxia Hu (170413)

“…</p>Results<p>In vitro cell experiments and transcriptomics showed that Sitagliptin phosphate decreased the secretion of inflammatory factors IL-6 and TNF-α induced by high-glucose, and increased secretion of anti-inflammatory factor IL-10 by enhancing macrophage polarization. …”

Image1_Hypoxia-induced PD-L1 expression and modulation of muscle stem cell allograft rejection.JPEG by Jacob Raiten (20021262)

“…In vivo, these preconditioned MuSCs led to decreased infiltration of CD4⁺ and CD8⁺ T cells in implanted limb muscles of mouse models. …”

Data Sheet 1_The vicious circle: how systemic barriers perpetuate maternity interpreting service inadequacies for migrant women in the UK.docx by Li Li (14993)

“…Introduction<p>Migrant women who speak languages other than English in the UK face elevated risks of adverse birth outcomes and experience significant maternal health disparities, conditions exacerbated by persistent inadequacies in interpreting service availability, quality, and costs. …”

Table 2_Rapid reshaping of the soil microbiome and metabolome during short-term flooding and draining in rice.xlsx by Yanyao Lu (22163632)

“…The results revealed that S-PPO, S-POD, and S-CAT decreased with prolonged drainage time, whereas the soil redox potential (Eh-mV) and POD increased. …”

Table 1_From challenge to competence: the role of learning engagement in mediating stress and performance among clinical medical students in English-medium dental education.docx by Runheng Liu (5221034)

“…While stress decreased over time in both groups, EMI students maintained consistently high engagement. …”

Table 3_Does COVID-19 vaccination affect risk perception and adherence to preventive behaviors? A systematic review and meta-analysis.docx by Michele Sorrentino (16538214)

“…Meta-analysis revealed no significant difference in risk perception between vaccinated (70.3, 95% CI 60.8–79.8) and unvaccinated subgroups (70.8, 95% CI 61.9–79.6; I² = 17.5%), suggesting limited influence on behavior maintenance.…”

DataSheet1_Effects of total flavonoids of Rhizoma Drynariae on biochemical indicators of bone metabolism: a systematic review and meta-analysis.DOCX by Wei Li (7081)

“…The tartrate-resistant acid phosphatase (TRACP) decreased significantly (WMD: −1.34; 95% CI: −1.62, −1.06; p < 0.00001). …”

Image 1_Berberine alleviates atherosclerosis by modulating autophagy and inflammation through the RAGE-NF-κB pathway.tif by Peng Zhang (2071)

“…Introduction<p>Lipid accumulation and foam cell formation are significant features that expedite the progression of atherosclerosis (AS). …”

Supplementary Material for: How the COVID-19 Pandemic Impacted Neurological Hospital Admissions in Germany - A Retrospective Analysis by figshare admin karger (2628495)

“…While overall admissions decreased, average case severity was significantly higher. …”

Data Sheet 1_Burden of NASH related liver cancer from 1990 to 2021 at the global, regional, and national levels.pdf by Shuang Li (146392)

“…At the national level, ASRs consistently decreased with higher SDI.</p>Conclusion<p>This study highlights the substantial burden of NRLC at global, regional, and national levels. …”