Data Sheet 1_Case Report: A case of first-line treatment for rare ROS1 fusion mutation lung adenocarcinoma with entrectinib.pdf by Yifan Yang (170387)

“…Subsequently, the patient underwent whole-brain radiotherapy. Significant improvements were noted in her headache and insomnia symptoms. …”

Image 3_Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer... by Chase Garcia (21803576)

“…</p>Results<p>At this concentration, BHB significantly and concentration-dependently decreased the following: 1) inflammatory cytokine expression (IL-6, TNF-α, and IL-1β), 2) inflammatory morphological changes, and 3) activation of p-ERK and p-p38MAPK, which are key pathways involved in microglial inflammation. …”

Supplementary file 1_Differential adaptations of japonica rice to submergence stress during the tillering stage under various seedling cultivation and transplanting methods.docx by Sumei Duan (18711099)

“…Over two-thirds of tillers survived under complete submergence for up to 7 days during the tillering stage. Submergence significantly affected POD and SOD activities, MDA and PRO contents, and SPAD values, characterized by initial increases followed by decreases in antioxidant enzyme activities, MDA accumulation, and PRO content elevation. …”

Supplementary file 1_Exploring dupilumab for asthma: from mechanistic insights to clinical outcomes, safety, and cost-effectiveness.docx by Omar Z. Ameer (8900039)

“…Clinical trials have demonstrated significant reductions in asthma exacerbation rates, improvements in forced expiratory volume in one second (FEV₁), and decreased oral corticosteroid (OCS) dependence in adults and children with moderate-to-severe asthma. …”

Supplementary file 1_Effects of different urban vegetation cover and green space types on soil greenhouse gas emissions and carbon sequestration.docx by Ruisha Zhang (21287978)

“…In comparison to park green spaces, the CO₂ flux of residential and street soils decreased by 2.11% and 3.25%, respectively, while the N₂O flux dropped by 16.61% and 22.41%, respectively. …”

Data Sheet 1_Top motor and non-motor complaints in patients with Parkinson's disease.docx by José Fidel Baizabal-Carvallo (11416508)

“…Cognitive impairment was a significant predictor of non-motor symptoms in their top three tiers [odds ratio [OR]: 3.88 (95% CI: 1.647 to 9.169)]. …”

Image 1_Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activa... by Jiaochen Luan (9704384)

“…Multi-omics analysis revealed significant enrichment in lipid metabolic pathways, with Fasn identified as a hub gene. …”

Pathogenicity and transmissibility differences in goose-originated subgenotype 3 duck Tembusu virus in goose embryos and 3-day-old goslings by Ziqiao Zhao (18785775)

“…In the autumn of 2022, an outbreak of an infectious disease resembling DTMUV was reported in Guangdong Province, China, which caused significantly high mortality in goose embryos, and decreased egg production. …”

Table 1_Association between androgenetic alopecia and psychological well-being: a systematic review and meta-analysis.docx by Yuan Kong (110669)

“…However, no significant difference was observed in general distress (pooled SMD = -0.01, 95% CI [-0.39,0.37], p = 0.97). …”

Data Sheet 1_Divergent trends and regional disparities in PM2.5 and O3 health economic burdens in China, 2013–2023: an integrated assessment with policy implications.zip by Ziqi Tang (10904159)

“…With 0 and 15 μg/m³ taken as the reference concentrations, all-cause mortality decreased by 47.41% (233,173 cases) and 65.55% (240,448 cases), respectively. …”

Table 7_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.xlsx by Fuxing Lin (7418234)

“…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …”

Supplementary file 1_Healthy lifestyle moderates the association between recent negative life events and depressive symptoms: a cross-sectional study.docx by Yang Yang (45629)

“…The overall lifestyle was observed as significant moderating role on the association between RNLEs and depressive symptoms (OR, 95%CI: 0.61 [0.40–0.95]).…”

LncRNA MCM3AP-AS1 protects against cerebral ischemia-reperfusion injury via targeting miR-27b-3p by Rouli Dai (17063211)

“…<p>Cerebral ischemia-reperfusion (CI/R) injury is a significant hurdle in ischemic stroke treatment. Substantial evidence indicates that long non-coding RNAs (lncRNAs) are implicated in CI/R injury. …”

Data Sheet 2_Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis.zip by Li Cui (37567)

“…ART showed the most significant improvements in BMI, IL-6, and TNF-α levels. …”

DataSheet2_Chitinase 1: a novel therapeutic target in metabolic dysfunction-associated steatohepatitis.docx by Jung Hoon Cha (19723588)

“…Although the population of F4/80⁺CD11b⁺ intrahepatic mononuclear phagocytes remained unchanged, their infiltration and activation (CHIT1⁺MerTK⁺) significantly decreased in OATD-01-treated mice, compared with that observed in vehicle-treated mice.…”

Data Sheet 1_Impact of a moderate-intensity aerobic exercise intervention on systemic and uterine natural killer cells in women with unexplained recurrent pregnancy loss.pdf by Aysel Gurbanova (21477746)

“…We also observed decreased percentages of IFN-γ⁺ pNK cells (49% vs 25.2%, p=0.027) after exercise.…”

Image 4_Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activa... by Jiaochen Luan (9704384)

“…Multi-omics analysis revealed significant enrichment in lipid metabolic pathways, with Fasn identified as a hub gene. …”

Datasheet1_Endovascular treatment of aortic coarctation using covered balloon-expandable stents—a systematic review and meta-analysis.pdf by Fei He (145896)

“…The estimated pooled procedural success rate was 100% [95% confidence interval (CI): 98%–100%, I2 = 0, P = 0.78]. Significant decreases in trans-coarctation PGs and SBP were observed. …”

Data Sheet 1_Post-COVID syndrome patients show reduced anti-Spike antibodies compared to COVID-recovered controls, but enhanced IgG4/IgG1 switch after the third vaccine dose.pdf by Nineth Rossi (22355524)

“…Introduction<p>Long COVID and post-COVID syndromes represent a significant global health crisis and a substantial societal challenge. …”

Data Sheet 1_Integrated physiological, transcriptomic, and metabolomic analyses of Chrysanthemum ‘Boju’ under excessive indole-3-acetic acid stress.pdf by Yuqing Wang (110531)

“…Exogenous IAA treatment also led to a significant reduction in endogenous hormone levels, including gibberellins (GA₃ and GA₄), abscisic acid (ABA), and IAA, with decreases of 93%, 45%, 99%, and 99%, respectively.Transcriptomic and metabolomic analyses identified 263 differentially expressed metabolites and 144 differentially expressed genes.…”