Supplementary file 1_Comprehensive real-time metabolic profiling of peripheral blood mononuclear cells reveals important methodological considerations for immunometabolism research... by Michael Macleod (22516823)

“…Extended blood processing time significantly lowered T cell activation capacity in PBMCs, evidenced by decreased responses of mitochondrial and glycolytic ATP supply to CD3/CD28 activation.…”

<b>Seasonal Hydrology and Projected Landscape Changes Jointly Shape Future Water Quality in a Typical Watershed of the Three Gorges Reservoir Area</b> by Xiaojun Zhao (22390147)

“…Under future scenarios of aggravated landscape fragmentation, TN concentrations decreased while TOC and COD_Mn concentrations significantly increased compared to the 2024 dry season. …”

Image 4_PRP pre-treatment of the implantation zone improves the survival rate of fat autograft.jpeg by Ilona Pak (21074279)

“…</p>Discussion<p>We have demonstrated that the pre-implantation use of platelet-rich plasma significantly improves the standard intraoperative technique and increases the survival rate of the fat autograft by enhancing angiogenesis, with a decreased degree of hypoxic-ischemic, fibrotic, and inflammatory damage in the implant area.…”

Image 4_SarZ inhibits the hemolytic activity through regulation of phenol soluble modulins in Staphylococcus epidermidis.jpeg by Xiao Chen (260187)

“…The sarZ psmβ double mutant was further generated and displayed a significantly decreased hemolytic activity compared with the sarZ mutant. …”

Table1_Cover crops lower the dispersal of grapevine foliar pathogens from the ground and contribute to early-season disease management.docx by Gultekin Hasanaliyeva (17752296)

“…This study explored the possibility of decreasing the use of fungicides to control these diseases using cover crops in the inter-row of vineyards. …”

Data Sheet 1_Integrative analysis of transcriptome and metabolome reveals molecular mechanisms of dynamic change of storage substances during dehydration and drying process in pean... by Jingjing Deng (468275)

“…S3d was the key period during which the content of most of the metabolites changed significantly. The contents of most amino acids(87%) and their derivatives decreased significantly, and most of the lipids(68%), sugars(67%) and flavonoids(87%) accumulated to their peak at S3d. …”

Table 1_Genome-wide analysis of lncRNA in wheat (Triticum aestivum) and functional characterization of TalncR9 in response to drought stress.xlsx by Lianzhe Wang (6202643)

“…Silencing TalncR9 in wheat reduced drought tolerance, decreased soluble sugar and proline levels, and increasing MDA levels. …”

Data Sheet 1_Potential cerebrospinal fluid metabolomic biomarkers and early prediction model for Parkinson’s disease.docx by Yifan Zhang (119570)

“…</p>Results<p>Sixty-four metabolites were significantly altered in PD patients compared to HC, with 58 elevated and 6 reduced. …”

Short-term antiretroviral therapy may not correct the dysregulations of plasma virome and cytokines induced by HIV-1 infection by Yingying Ma (3617810)

“…These results suggest that short-term ART may not significantly correct the virome and cytokine dysregulations induced by HIV-1 infection. …”

Data Sheet 1_Lysate of Parabacteroides distasonis prevents severe forms of experimental autoimmune encephalomyelitis by modulating the priming of T cell response.docx by Zuzana Jiraskova Zakostelska (6386825)

“…EAE induction was the main factor in altering the gut microbiota, decreasing the abundance of lactobacilli and segmented filamentous bacteria. …”

Data Sheet 1_Dietary canthaxanthin improves egg production rate through regulating hepatic lipid metabolism and redox status in indigenous chickens.docx by Jie Chen (5892)

“…At week 9, 8 mg/kg CX significantly decreased serum MDA levels (p < 0.05). …”

Supplementary Material for: Using smartphone data to frequently measure atopic dermatitis severity and understand triggers: A decentralized 12-week observational study by Ali Z. (5634332)

“…Decreasing temperature was significantly associated with higher POEM (estimate -0.18, p=0.012) and EASI score (estimate -0.14, p=0.007), but not with SCORAD. …”

Supplementary Material for: Hypothyroidism promotes microglia M1 polarization by inhibiting BDNF-promoted PI3K-Akt signaling pathway by Zhan Y. (4157410)

“…In BV2 cells, LPS treatment decreased expression of BDNF, IL-10, and Arg1, while BDNF overexpression (BDNF-OE) significantly reversed the inflammation-induced by LPS by repressing iNOS and TNF-α, while increasing IL-10 and Arg1. …”

Supplementary Material for: High expression of tetraspanin CD63 predicts poor prognosis in esophageal squamous cell carcinoma by Matsumoto Y. (2866151)

“…Herein, we report the significance of CD63 expression by analyzing ESCC patient samples and ESCC cell lines. …”

Table 1_Nanocarrier-mediated RNAi of CYP9E2 and CYB5R enhance susceptibility of invasive tomato pest, Tuta absoluta to cyantraniliprole.docx by Farman Ullah (783297)

“…Notably, nanocarrier-encapsulated dsRNA targeting CYB5R and CYP9E2 genes significantly reduced their expression levels. Further, the activity of cytochrome P450 was substantially decreased after the knockdown of the CYB5R and CYP92 genes. …”

Supplementary file 1_Effects of human urine application on soil physicochemical properties, microbial communities, and enzymatic activities.docx by Guangquan Yu (21630101)

“…<p>Human urine (HU) is rich in nutrients necessary for plant growth, and recycling HU as fertilizer has multiple positive impacts, such as enhancing agricultural sustainability, reducing wastewater pollution, and decreasing reliance on chemical fertilizers, so it is of great significance to explore the effects of urine agricultural utilization on soil environment. …”

Table 1_Safety and efficacy comparison of single-stage and two-stage ERCP combined with laparoscopic cholecystectomy: a meta-analysis and systematic review.xlsx by Jian-Xiong Tai (22696688)

“…The incidence of pancreatitis was significantly higher in the sequential surgery group compared to LERV (RR = 1.90, 95% CI: 1.61–2.24). …”

Data from: The relationship between pollinator community and pollination services is mediated by floral abundance in urban landscapes by Hamutahl Cohen (11520447)

“…In the field, we found that jalapeño seed number increased significantly with herbaceous (weed, crop, and ornamental) plant richness and the number of perennial trees and shrubs at the site level, but decreased with the amount of natural landscape cover. …”

Data Sheet 1_Investigating the underlying mechanisms of the ethanol extract of saussureae involucratae herba in anti-rheumatoid arthritis effect based on sphingolipidomics.pdf by Pingyuan Chi (21563069)

“…In cell assays, SIE significantly decreased the protein levels of TNF-α and IL-6 (both P < 0.01) in LPS-stimulated RAW 264.7 cells. …”

Supplementary Material for: Protein inhibitor of activated STAT 2 (PIAS2) protects against podocyte injury in diabetic nephropathy via inhibiting JAK2/STAT3 pathway by figshare admin karger (2628495)

“…Overexpression of PIAS2 significantly reversed high glucose-induced human podocytes injury, evidenced by increased cell viability, reduced cell apoptosis, decreased expression of pro-apoptotic proteins Bax and cleaved-Caspase3, increased expression of the anti-apoptotic protein Bcl-2, and reduced secretion of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. …”