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    Oxidative Nickel-Catalyzed <i>ortho</i>-C–H Amination of (Iso)quinolines with Alicyclic Amines Directed by a Sacrificial <i>N</i>‑Oxide Group by Weiqi Zhu (17845973)

    Published 2024
    “…Transition metal (TM)-catalyzed direct amination of C–H bonds on free or fused pyridine (Py) rings with free amines still remains scarce because amines and the Py ring tend to adopt a nonproductive N-bound coordination with many TMs, leading to a significant decrease of catalytic reactivity. We herein disclose a nickel-catalyzed and a sacrificial <i>N</i>-oxide group directed oxidative coupling of (iso)quinolyl C–H bonds and alicyclic amines, which furnishes bioimportant amino(iso)quinolines efficiently and selectively in a single step. …”
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