Molecular docking showed that ABT-199 can fit into active site of ALK^Mutant. by Richard Junior Zapata Dongo (17912565)

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The binding energy values of ATP, ALK inhibitors and ABT-199 to ALK were obtained from AlphaFold and modeled protein structures. by Richard Junior Zapata Dongo (17912565)

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Amino acids interactions and binding energy describe that ABT-199 binds to ALK^Mutant. by Richard Junior Zapata Dongo (17912565)

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Western blot analysis of drug combinations. by Richard Junior Zapata Dongo (17912565)

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ALKL1196M –ABT199 interactions. by Richard Junior Zapata Dongo (17912565)

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ALK^wt–ABT199 interactions. by Richard Junior Zapata Dongo (17912565)

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BCL2 protein keeps their expression in different conditions treatment nevertheless each EML4-ALK cell modells exhibit variable expression. by Richard Junior Zapata Dongo (17912565)

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ALK inhibitors (Positive control) and ABT199 (Proposed binding) in complex with the ALK active side. by Richard Junior Zapata Dongo (17912565)

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BCL2 antiapoptotic protein exhibits heterogeneous expression in Ba/F3 EML4-ALK^mutants. by Richard Junior Zapata Dongo (17912565)

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Loewe synergy-antagonism score analysis shows additive and synergistic effects after ALKi and ABT-199 combination treatment. by Richard Junior Zapata Dongo (17912565)

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Negative (Prednisone) and basal (ATP) control compounds binding to ALK protein. by Richard Junior Zapata Dongo (17912565)

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Scatter plots of the relationships between age and the proportions of cells which statistically significantly correlated with age. by Arttu Autio-Kimura (20454681)

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Moderate correlation (R² = 0.136 p = .0085) between Medicare prescriptions per 1,000 persons and the percentage of white population among the fifty US states. by Luke R. Cavanah (19022435)

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Large state-wide variation (8.6-fold) in number of clozapine prescriptions per thousand Medicare Part D enrollees in 2018 ^a indicates ≥1.50 SD (17.9) from the mean (32.9... by Luke R. Cavanah (19022435)

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Strong correlation (R² = 0.734 p < .0001) between Medicare prescriptions per 1,000 persons and Medicaid prescriptions per 1,000 persons among the fifty US states in 2019... by Luke R. Cavanah (19022435)

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Large state-wide variation (11.1-fold) in number of clozapine prescriptions per thousand Medicare Part D enrollees in 2015 ^a indicates ≥1.50 SD (20.2) from the mean (36.... by Luke R. Cavanah (19022435)

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Large state-wide variation (8.6-fold) in number of clozapine prescriptions per thousand Medicare Part D enrollees in 2017 ^a indicates ≥1.50 SD (18.0) from the mean (33.1... by Luke R. Cavanah (19022435)

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Medicare clozapine data analysis. by Luke R. Cavanah (19022435)

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Large state-wide variation (8.5-fold) in number of clozapine prescriptions per thousand Medicare Part D enrollees in 2019 ^a indicates ≥1.50 SD (16.8) from the mean (31.0... by Luke R. Cavanah (19022435)

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Large state-wide variation (8.6-fold) in number of clozapine prescriptions per thousand Medicare Part D enrollees in 2020 ^a indicates ≥1.50 SD (16.0) from the mean (29.9... by Luke R. Cavanah (19022435)

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