Neonatal autoimmune lymphoproliferative syndrome with a novel pathogenic homozygous FAS variant effectively treated with sirolimus: Case report by Fawzia M. Elgharbawy (17045534)

“…<h3>Background</h3><p dir="ltr">Autoimmune lymphoproliferative syndrome (ALPS) is a rare disease characterized by defective FAS signaling, which results in chronic, nonmalignant lymphoproliferation and autoimmunity accompanied by increased numbers of “double-negative” T-cells (DNTs) (T-cell receptor αβ+ CD4−CD8−) and an increased risk of developing malignancies later in life.…”

Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis by Maria K. Smatti (4675852)

“…Remarkably, Africans seem to carry extremely lower frequencies of SARS-CoV-1 susceptibility alleles, reaching to 32-fold decrease compared to other populations.</p><h3>Conclusion</h3><p dir="ltr">Multiple genetic variants, which could potentially modulate SARS-CoV-2 infection, are significantly variable between populations, with the lowest frequency observed among Africans. …”

Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy by Nassiba Taib (14557385)

“…</p><h2>Results</h2><p dir="ltr">DAC treatment significantly upregulated stemness markers in both primary 1076 Col and meta-static 1872 Col cell lines, although a lower effect occurred on the latter: CD44 (7.85 fold; ***p = 0.0001 vs. (4.19 fold; *p = 0.0120), Nanog (4.1 fold; ***p < 0.0001 vs.1.69 fold; ***p = 0.0008), KLF-4 (4.33 fold; ***p < 0.0001 vs.2.48 fold; ***p = 0.0005), CD133 (16.77 fold; ***p = 0.0003 vs.6.36 fold; *p = 0.0166), and MSI-1 (2.33 fold; ***p = 0.0003 vs.2.3 fold; ***p = 0.0004), respectively. …”

Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine by Hamda A. Al-Naemi (14151675)

“…Exposure to Cd increases the risk of cardiovascular disease by disrupting vascular homeostasis at the endothelium. …”

Targeting Breast Cancer Using Hyaluronic Acid-Conjugated Liposomes Triggered with Ultrasound by Ben-Daya, Mohamed

“…HA conjugation to the liposomes resulted in a significant increase in calcein uptake by the breast cancer cell line MDA-MB-231 known for its CD44 (HA receptor) overexpression, while such an effect was not recorded with NIH-3T3, an embryonic mouse fibroblast, with low levels of CD44 expression. …”
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Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population by Ghassibe-Sabbagh, Michella

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A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells by Abou-Ghazal, Mohamed K.

“…The p-STAT3 inhibitor WP1066 enhanced CD3+ (which contained Tregs) but not CD8+ T cell cytotoxicity against human A375 melanoma cells, indicating that this p-STAT3 blockade agent did not directly activate CD8+ T cells. …”
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Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells <i>via</i> Tryptophan 2,3 Dioxygenase by Marta Cecchi (21363581)

“…Expression of cancer stem cell markers (CD133, CD44, ganglioside GD2) was significantly increased in A375 spheres, as detected by flow cytometry. …”

Squamous Cell Carcinomas of the Head and Neck Cancer Response to Programmed Cell Death Protein-1 Targeting and Differential Expression of Immunological Markers: A Case Report by Maysaloun Merhi (4246147)

“…The NY-ESO-1-specific T cells response of the patient was found to be increased after the third and the fifth (**p = 0.002) cycles of treatment but had a significant decline after progression (**p = 0.0028). …”

Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death by Tohme, Sara

“…Acute Myeloid Leukemia (AML) poses significant challenges due to its unfavorable prognosis and limited treatment options, particularly in elderly patients. …”
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Risk Factors for Post-Cesarean, Surgical Site Infections in a Multi-Ethnic Population of Qatar by Sufia Athar (14777830)

“…In our hospital, the SSIs after CD were noted to increase in 2016 and first quarter of 2017. …”

Exposure to Toxic Metals from the Consumption of Cornflakes in Lebanon by El Khoury, Celine

“…Estimated Daily Intake (EDI) and Hazard Quotient (HQ) calculations indicated no significant health risk for adults. Nevertheless, the frequent detection of contaminated samples and the increasing consumption of ready-to-eat cereals raise concerns about cumulative exposure, particularly among children. …”
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A genome-wide transcriptomic analysis of embryos fathered by obese males in a murine model of diet-induced obesity by Laura Bernhardt (14152842)

“…Furthermore, we could show a significant increase in expression of both Gata6 and Samd4b during differentiation of stromal vascular cells into mature adipocytes. …”

Health-related quality of life and its predictors among adults living with HIV/AIDS and receiving antiretroviral therapy in Pakistan by Ali Ahmed (2567584)

“…Multivariate linear regression analysis revealed that the factors significantly associated with HRQoL were: female gender; age  > 50 years; having primary and secondary education;  > 1 year since HIV diagnosis; HIV serostatus AIDS-converted; higher CD 4 T lymphocytes count; detectable viral load; and increased time to ART.…”

Optimisation of PV Cleaning Practices: Comparison Between Performance Based and Periodic Based Approaches by ALHAJERI, RASHED ABDULLA

“…Higher relative humidity, drier desert climates, larger dust particles/concentration, and lower PV panel tilt angle are all examples of how soiling or its effects are increased. The losses resulting from this can lead to significant losses, especially in a place like Dubai, UAE which meet many of these factors. …”
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Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma by Peter Kubatka (11008854)

“…In treated rat carcinomas, we found significant caspase-3, Bax, and Bax/Bcl-2 expression increases; on the other side, a significant down-regulation of Bcl-2, Ki67, CD24, ALDH1, and EpCam expressions and MDA levels. …”

Therapeutic Impact of P-PENT, P-HEX and 5CLSS (IV) Platinum (IV) complexes on Acute Myeloid Leukemia in vitro and in vivo by Bou Chacra, Joelle

“…A significant increase in ROS production was also observed upon cell treatment with the complexes. …”
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Differential water quality in confined and free-flowing water bodies, Lebanon by Korfali, Samira Ibrahim

“…Measured water parameters were temperature, pH, conductivity, BOD, HCO3-, Ca2+, Mg2+, Cl-, SO42-, PO43-, NO3-, NH3, Fe, Mn, Zn, Pb, and Cd. Statistical analysis of the data revealed significant differences in water quality. …”
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An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - Are your sorted cells getting SICS? by Gerald Pfister (17075275)

“…These findings are evaluated and their potential significance in cell sorting experiments is discussed.…”

Wound healing potential of quercetin-3-O-rhamnoside and myricetin-3-O-rhamnoside isolated from Pistacia lentiscus distilled leaves in rats model by Wiem Elloumi (17148337)

“…Also, the expression of the pro-inflammatory factor TNF-α and the angiogenesis marker CD-31 in PDL 20, MM, and QM treated groups is lower than in the negative control group. …”