Preparation of albumin-targeted liposomes and the study of their release characteristics using ultrasound by Turki, Renad

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Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy by Samson Mathews Samuel (18808246)

“…We observed robust up-regulation of anti-angiogenic thrombospondin-1 (TSP1) and increased TSP1-CD36 co-localization with a marked decrease in the levels of phosphorylated vascular endothelial growth factor receptor-2 (pVEGFR2; Y1175) in 2DG (5 mM) exposed cells treated with metformin (2 mM). …”

Co-occurrence of antibiotic and metal resistance in long-term sewage sludge-amended soils: influence of application rates and pedo-climatic conditions by Sonia Mokni-Tlili (20487266)

“…Nine isolates showed significant MAR index (≥ 0.3) and co-resistance to Cd, As and Be as well. …”

PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer by Reem Saleh (3513056)

“…Gene set enrichment analyses revealed that a significant number of these genes are related to the NF-kB, PI3K/Akt/mTOR, MAPK, and CD40 signaling pathways. …”

Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer by Adviti Naik (673163)

“…In direct co-cultures, <i>LDHC</i> knockdown reduced the levels of pro-tumorigenic cytokines (IL-1β, IL-4 and IL-6) and increased the secretion of the chemokine CXCL1. In addition, the number of CD8 + T cells expressing PD-1 and CTLA-4 and the cell surface expression of CTLA-4, TIGIT, TIM3, and VISTA were reduced.…”

Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy by Remy Thomas (702843)

“…More specifically, we found an increase in IFN-γ secretion by CD8 + T cells and cancer-cell-killing of HLA-A*0201/LDHC positive breast cancer cells by LDHC⁴¹⁻⁵⁵- and LDHC^288−303-induced T cells, albeit with a possible antigen recognition threshold. …”

Positional and dimensional temporomandibular joint osseous changes in patients treated with the forsus fatigue resistant device: a non-randomized clinical trial by Ramy Abdul-Rahman Ishaq (22928974)

“…In the treatment group, condylar width decreased significantly by 0.52 ± 0.92 mm, in contrast to an increase of 0.17 ± 0.35 mm in the control group (<i>P</i> = 0.010). …”

Dexmedetomidine for improved quality of emergence from general anesthesia by Aoud, MT

“…The respective incidences for the groups D 1, D 0.5, and D 0.25 versus group C were 48%, 64%, and 64% vs 84% for cough-corrected P < .003 between groups D 1 and C; 33%, 34%, and 33% vs 72% for agitation-corrected P < .003 between group C and each of the study groups; and 4%, 2%, and 7% vs 22% for shivering-corrected P = .03 and corrected P = .009 between groups D 1 and D 0.5 versus group C, respectively. The percent increase from baseline blood pressure on extubation for the 3 treatment groups was significantly lower than group C. …”
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