Showing 5,781 - 5,800 results of 8,227 for search '(( significant challenge decrease ) OR ( significant ((changes decrease) OR (largest decrease)) ))', query time: 0.51s Refine Results
  1. 5781

    Table 1_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.docx by Xiao Li (107004)

    Published 2024
    “…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”
  2. 5782

    Image 3_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.jpeg by Xiao Li (107004)

    Published 2024
    “…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”
  3. 5783

    Image 1_The gut microbiota in liver transplantation recipients during the perioperative and postoperative recovery period.png by Zhongyuan Bai (8859077)

    Published 2025
    “…Metagenomic sequencing, analyzed using the LEfSe method, identified a total of 50 genera that played significant roles in this process. The changes in microbiota exhibited the same trend as the 16S rRNA results. …”
  4. 5784

    Image 2_The gut microbiota in liver transplantation recipients during the perioperative and postoperative recovery period.jpeg by Zhongyuan Bai (8859077)

    Published 2025
    “…Metagenomic sequencing, analyzed using the LEfSe method, identified a total of 50 genera that played significant roles in this process. The changes in microbiota exhibited the same trend as the 16S rRNA results. …”
  5. 5785

    Related to Fig 3. by Mohammad Nafees Ansari (22232505)

    Published 2025
    “…(<b>O</b>, <b>P</b>) Cell proliferation assay confirms an increase in cell proliferation of BT-474_ZFX<sup>OE</sup> cells (mean ± SEM, <i>n</i> = 5) (O), whereas BT-474_ZFX<sup>SL</sup> cells (mean ± SEM, <i>n</i> = 3) show decreased cell proliferation (P). (<b>Q</b>) Tumor growth kinetics recorded a significantly higher growth of BT-474_ZFX<sup>OE</sup> (mean ± SEM, <i>n</i> = 5) than BT-474_VECT<sup>OE</sup> tumors. …”
  6. 5786

    Table 1_GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.xlsx by Fumiya Ito (14833366)

    Published 2025
    “…However, resistance to EGFR inhibitors, such as erlotinib, presents a significant challenge in treating lung cancer. In this study, we established an EGFR-independent, erlotinib-resistant (ER) phenotype in lung cancer A549 cells by exposing them to erlotinib for an extended period. …”
  7. 5787

    Data Sheet 1_GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.pdf by Fumiya Ito (14833366)

    Published 2025
    “…However, resistance to EGFR inhibitors, such as erlotinib, presents a significant challenge in treating lung cancer. In this study, we established an EGFR-independent, erlotinib-resistant (ER) phenotype in lung cancer A549 cells by exposing them to erlotinib for an extended period. …”
  8. 5788
  9. 5789

    Data_Sheet_1_Effects of household solid fuel use on sarcopenia in middle-aged and older adults: evidence from a nationwide cohort study.docx by Shaohui Su (19779057)

    Published 2024
    “…Switching to clean cooking fuels significantly reduced sarcopenia risk (HR 0.766, 95% CI 0.599–0.979). …”
  10. 5790

    Image 2_Dietary risk factors and cancer mortality burden from 1990 to 2021: a comparative study of China and global regions with varying sociodemographic development levels based o... by Chunxiu Zhao (21650204)

    Published 2025
    “…Joinpoint regression models quantified temporal trends through Annual Percent Change (APC) and Average Annual Percent Change (AAPC).…”
  11. 5791

    Data Sheet 1_Dietary risk factors and cancer mortality burden from 1990 to 2021: a comparative study of China and global regions with varying sociodemographic development levels ba... by Chunxiu Zhao (21650204)

    Published 2025
    “…Joinpoint regression models quantified temporal trends through Annual Percent Change (APC) and Average Annual Percent Change (AAPC).…”
  12. 5792

    Image 1_Dietary risk factors and cancer mortality burden from 1990 to 2021: a comparative study of China and global regions with varying sociodemographic development levels based o... by Chunxiu Zhao (21650204)

    Published 2025
    “…Joinpoint regression models quantified temporal trends through Annual Percent Change (APC) and Average Annual Percent Change (AAPC).…”
  13. 5793

    Image 3_Dietary risk factors and cancer mortality burden from 1990 to 2021: a comparative study of China and global regions with varying sociodemographic development levels based o... by Chunxiu Zhao (21650204)

    Published 2025
    “…Joinpoint regression models quantified temporal trends through Annual Percent Change (APC) and Average Annual Percent Change (AAPC).…”
  14. 5794

    Short-Ranged United-Atom Model for Efficient Simulations of Glycerol and Its Aqueous Mixtures by Prabir Khatua (1738339)

    Published 2025
    “…Capturing its structural and thermodynamic properties in liquid and glass states remains challenging due to discrepancies between NMR, neutron scattering experiments, and all-atom (AA) simulations. …”
  15. 5795

    Table 1_Impact of removing laver (Porphyra) farming racks on the distribution, diversity and foraging behavior of waterbirds in coastal wetlands in eastern China.xlsx by Taiyu Chen (6063248)

    Published 2025
    “…Notably, the numbers of ducks, plovers, and sandpipers increased significantly, while gull numbers decreased significantly, likely due to habitat structure loss. (3) The proportion of foraging behaviors of 4 common waterbird species increased significantly after restoration, while the percentage of resting behavior significantly decreased. (4) No significant differences in macrobenthos species richness, abundance, biomass or α-diversity indices were detected post-restoration, but the macrobenthos in laver racks area (lower tidal zone) were significantly more abundant than those in the non-racks area (middle tidal zone).…”
  16. 5796

    Data Sheet 1_The expression regulation of recA gene and bacterial class 2 integron-associated genes induced by antibiotics.xlsx by Jinglu Ye (18768758)

    Published 2025
    “…Induced strains exhibited increased resistance to the drugs, with the most significant changes observed in the clinical isolates, particularly concerning CIP resistance. …”
  17. 5797

    Table 2_The expression regulation of recA gene and bacterial class 2 integron-associated genes induced by antibiotics.xlsx by Jinglu Ye (18768758)

    Published 2025
    “…Induced strains exhibited increased resistance to the drugs, with the most significant changes observed in the clinical isolates, particularly concerning CIP resistance. …”
  18. 5798

    Table 1_Ultrasonographic assessment of optic nerve sheath diameter on the affected and unaffected sides as a predictor of clinical deterioration at discharge in patients with large... by Changlan Li (704841)

    Published 2025
    “…Longitudinal changes in bilateral ONSD showed remarkable overlap in both individual and group observations. …”
  19. 5799

    Discriminatory learning preferentially enhances reward associated input. by Rahul Garg (3064578)

    Published 2025
    “…(E) Fraction of glomeruli with significant changes post learning. Yellow: increased, dark grey: decreased, light grey: unchanged. …”
  20. 5800

    Data Sheet 1_Increased accrual of diverse patient populations in oncology phase I clinical trials at the University of Colorado Cancer Center.docx by Ahmed Alsafar (21716735)

    Published 2025
    “…However, in the most common cancer type, colorectal cancer, higher ADI scores were associated with decreased median PFS and OS.</p>Conclusion<p>The interventions resulted in an increase in accrual of non-English speaking patients, however, there was not yet a significant change in overall race and ethnicity. …”