يعرض 6,301 - 6,320 نتائج من 8,227 نتيجة بحث عن '(( significant challenge decrease ) OR ( significant ((changes decrease) OR (largest decrease)) ))', وقت الاستعلام: 0.52s تنقيح النتائج
  1. 6301

    Table 1_Carnosine as a protective metabolic mediator in inflammatory lung injury by inhibiting macrophage infiltration and M1-like polarization.docx حسب Lianjie Ruan (22660265)

    منشور في 2025
    "…To evaluate its therapeutic potential, we administered exogenous carnosine in both models and assessed its effects on body weight, inflammatory cytokine expression, and histopathological changes.</p>Results<p>Carnosine supplementation significantly improved body weight maintenance, reduced the expression of pro-inflammatory cytokines, and attenuated histological lung damage in both LPS- and papain-induced lung injury models. …"
  2. 6302

    Raw Data حسب Kevin Gries (21956942)

    منشور في 2025
    "…These findings indicate that a single day of reduced physical activity can elicit modest but significant changes in the metabolic and transcriptomic exercise response. …"
  3. 6303

    Data Sheet 2_Identification of the malonylation modification in Staphylococcus aureus and insight into the regulators in biofilm formation.xlsx حسب Xiaoyan Yu (319080)

    منشور في 2025
    "…</p>Results<p>Quantitative profiling identified 2,833 malonylated sites across 788 proteins, with significant enrichment in biofilm-associated proteins. …"
  4. 6304

    Supplementary Material for: Adjuvant Lip Gauze Wet Dressing Restores Lip Barrier Function and Improves Atopic Cheilitis حسب figshare admin karger (2628495)

    منشور في 2025
    "…Results indicated that patients exhibited decreased lip barrier function, which improved significantly with gauze wet dressing, enhancing hydration and normalizing pH levels within 30 minutes. …"
  5. 6305

    Table 1_High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota.xlsx حسب Yu Xia (8822)

    منشور في 2025
    "…Furthermore, oral administration of high-dose thiamine also regulated HFFD-induced gut microbiota dysbiosis by reshaping its structure and composition of gut microbiota, such as increasing the relative abundance of Actinobacteria and Bifidobacterium pseudolongum, and reducing the relative abundance of Proteobacteria and Ruminococcus gnavus, accompanied by decreased level of gut-derived endotoxin. Finally, significant correlations were found between obesity-related phenotypes and gut microbiota through correlation analysis.…"
  6. 6306

    Data Sheet 1_Comprehensive analysis on the regulatory mechanism of active ingredient accumulation during fermentation process of Massa Medicata Fermentata: microbe and metabolic pr... حسب Yun Li (692280)

    منشور في 2025
    "…In this study, we aimed to investigate the dynamic changes and correlations of physicochemical properties, microbial communities, and metabolite profiles in different fermentation stages (0, 48, 72, and 96 h) of MMF.…"
  7. 6307

    Data_Sheet_1_Efficacy of transcranial magnetic stimulation treatment in reducing neuropsychiatric symptomatology after traumatic brain injury.PDF حسب Gianna Carla Riccitelli (19823673)

    منشور في 2024
    "…After 4 weeks, impulsivity further declined, though no other significant changes were noted. At 8 weeks, a persistent positive effect was observed, including enhanced positive emotions.…"
  8. 6308

    Data Sheet 1_In vivo profiling of the PE/PPE proteins of Mycobacterium tuberculosis reveals diverse contributions to virulence.pdf حسب Benjamin Koleske (11581641)

    منشور في 2025
    "…We found consistent, time-dependent changes in mutant abundance across our animal replicates and identified decreases in several key mutant strains known to promote bacterial growth or virulence. …"
  9. 6309

    Table 1_Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.docx حسب Helena Hernández-Cuervo (9956465)

    منشور في 2025
    "…</p>Results<p>Mice lacking Bmi1 versus WT exposed to hyperoxia exhibited hallmarks of human acute lung injury (ALI) such as increased lung permeability, alveolar edema, hemorrhage, interstitial thickening, and infiltration of immune cells; and alterations in lung mechanics, including increased elastance and decreased lung compliance.</p>Discussion<p>Bmi1<sup>−/−</sup> mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to WT mice. …"
  10. 6310

    Image 11_Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.tif حسب Helena Hernández-Cuervo (9956465)

    منشور في 2025
    "…</p>Results<p>Mice lacking Bmi1 versus WT exposed to hyperoxia exhibited hallmarks of human acute lung injury (ALI) such as increased lung permeability, alveolar edema, hemorrhage, interstitial thickening, and infiltration of immune cells; and alterations in lung mechanics, including increased elastance and decreased lung compliance.</p>Discussion<p>Bmi1<sup>−/−</sup> mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to WT mice. …"
  11. 6311

    Table 8_The impact of Helicobacter pylori infection and eradication therapies on gut microbiota: a systematic review of microbial dysbiosis and its implications in gastric carcinog... حسب Alia Albush (21669206)

    منشور في 2025
    "…</p>Results<p>A total of 45 studies met the inclusion criteria, which evaluated microbial changes in H. pylori -infected individuals before and after eradication therapies. …"
  12. 6312

    Presentation 1_Combination of αCD4 antibody and retinal antigen injection induces long-term disease control in autoimmune uveitis.pptx حسب Dijie Qiao (22063459)

    منشور في 2025
    "…Flow cytometry was employed to analyze immune cell infiltration, and RNA sequencing of ocular tissue was performed to assess gene expression changes.</p>Results<p>Mice receiving aCD4 antibody and IRBP1-20 showed sustained disease control up to 28 weeks, with reduced ocular inflammation, less retinal damage on OCT, and decreased immune cell infiltration compared to untreated controls. …"
  13. 6313

    Table 3_Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.xlsx حسب Jiahui Chang (15359305)

    منشور في 2025
    "…The lactylation levels of Mtatp8, Atp5mg, and Atp5po proteins in the exercise group were significantly decreased, while their protein levels were significantly increased. …"
  14. 6314

    Table9_Dynamics of flavonoid metabolites in coconut water based on metabolomics perspective.xlsx حسب Mingming Hou (11341656)

    منشور في 2024
    "…The total flavonoid content in both types of coconut water exhibited a decreasing trend with developmental progression, but the total flavonoid content in CK was significantly higher than that in W5. …"
  15. 6315

    Presentation 1_Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.pptx حسب Helena Hernández-Cuervo (9956465)

    منشور في 2025
    "…</p>Results<p>Mice lacking Bmi1 versus WT exposed to hyperoxia exhibited hallmarks of human acute lung injury (ALI) such as increased lung permeability, alveolar edema, hemorrhage, interstitial thickening, and infiltration of immune cells; and alterations in lung mechanics, including increased elastance and decreased lung compliance.</p>Discussion<p>Bmi1<sup>−/−</sup> mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to WT mice. …"
  16. 6316

    Image 1_Global burden of endometriosis from 1990 to 2021 and projections to 2050: a comprehensive analysis based on the global burden of disease study 2021.tif حسب Xiaochuan Yu (2410861)

    منشور في 2025
    "…Future research should investigate the effects of population aging and lifestyle changes on the burden of EMT.</p>…"
  17. 6317

    Table7_Dynamics of flavonoid metabolites in coconut water based on metabolomics perspective.xlsx حسب Mingming Hou (11341656)

    منشور في 2024
    "…The total flavonoid content in both types of coconut water exhibited a decreasing trend with developmental progression, but the total flavonoid content in CK was significantly higher than that in W5. …"
  18. 6318

    Image 3_Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.tif حسب Jiahui Chang (15359305)

    منشور في 2025
    "…The lactylation levels of Mtatp8, Atp5mg, and Atp5po proteins in the exercise group were significantly decreased, while their protein levels were significantly increased. …"
  19. 6319

    Table 1_Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.xlsx حسب Jiahui Chang (15359305)

    منشور في 2025
    "…The lactylation levels of Mtatp8, Atp5mg, and Atp5po proteins in the exercise group were significantly decreased, while their protein levels were significantly increased. …"
  20. 6320

    Image 3_Global burden of endometriosis from 1990 to 2021 and projections to 2050: a comprehensive analysis based on the global burden of disease study 2021.tif حسب Xiaochuan Yu (2410861)

    منشور في 2025
    "…Future research should investigate the effects of population aging and lifestyle changes on the burden of EMT.</p>…"