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challenge » challenges (Expand Search)
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6381
Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario
Published 2025“…<p>Preeclampsia (PE) is characterized by systemic endothelial dysfunction and remains a significant clinical challenge. Activation of NLRP3 inflammasome, reactive oxygen species (ROS) production, and pyroptosis and autophagy are important mechanisms in this condition. …”
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6382
DataSheet1_Polystyrene microplastics exposition on human placental explants induces time-dependent cytotoxicity, oxidative stress and metabolic alterations.pdf
Published 2024“…Levels of mitochondrial and total superoxide anion (p < 0.01 and p < 0.05, respectively) and hydrogen peroxide (p < 0.001) were significantly elevated. PS-MP exposure resulted in a reduction in total sulfhydryl content (p < 0.05) and the activities of antioxidant enzymes superoxide dismutase (p < 0.01) and catalase (p < 0.05), while glutathione peroxidase activity increased (p < 0.05), and the oxidized/reduced glutathione ratio decreased (p < 0.05). …”
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6383
Data Sheet 1_Burn inhalation injury and intubation with dexamethasone-eluting endotracheal tubes modulate local microbiome and alter airway inflammation.xlsx
Published 2025“…Differential abundance analysis demonstrated significant positive log fold changes in genera such as Bergeriella, Peptostreptococcus, and Bacteriodes with thermal injury over time. …”
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6384
Image 6_Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in...
Published 2025“…</p>Results<p>Behavioral tests demonstrated that LPS-induced rats exhibited significant depressive-like behaviors, including reduced sucrose preference, decreased activity levels in the open field, and restricted exploratory behavior in the elevated plus maze. taVNS intervention significantly alleviated these depressive-like behaviors. …”
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6385
Image 2_Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in...
Published 2025“…</p>Results<p>Behavioral tests demonstrated that LPS-induced rats exhibited significant depressive-like behaviors, including reduced sucrose preference, decreased activity levels in the open field, and restricted exploratory behavior in the elevated plus maze. taVNS intervention significantly alleviated these depressive-like behaviors. …”
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6386
Image 5_Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in...
Published 2025“…</p>Results<p>Behavioral tests demonstrated that LPS-induced rats exhibited significant depressive-like behaviors, including reduced sucrose preference, decreased activity levels in the open field, and restricted exploratory behavior in the elevated plus maze. taVNS intervention significantly alleviated these depressive-like behaviors. …”
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6387
Data Sheet 1_Impact of individualized and structured aerobic exercise on clinical outcomes in pediatric congenital heart diseases with post-surgical rehabilitation: a meta-analysis...
Published 2025“…Background<p>Children with congenital heart defects (CHD) commonly experience decreased exercise capacity due to structural heart abnormalities, surgical interventions, and parental-and physician-imposed activity restrictions. …”
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6388
Image 10_Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway i...
Published 2025“…</p>Results<p>Behavioral tests demonstrated that LPS-induced rats exhibited significant depressive-like behaviors, including reduced sucrose preference, decreased activity levels in the open field, and restricted exploratory behavior in the elevated plus maze. taVNS intervention significantly alleviated these depressive-like behaviors. …”
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6389
Table 1_Efficacy and safety of esketamine in patients undergoing painless gastrointestinal endoscopy: a systematic review and meta-analysis of randomized controlled trials.doc
Published 2025“…Safety outcomes indicated significantly reduced intraoperative hypotension, bradycardia, apnea, cough, body movement and injection pain, alongside transient increases in HR and MAP during instrumentation without clinically significant SpO<sub>2</sub> changes. …”
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6390
Image 9_Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in...
Published 2025“…</p>Results<p>Behavioral tests demonstrated that LPS-induced rats exhibited significant depressive-like behaviors, including reduced sucrose preference, decreased activity levels in the open field, and restricted exploratory behavior in the elevated plus maze. taVNS intervention significantly alleviated these depressive-like behaviors. …”
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6391
Image 8_Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in...
Published 2025“…</p>Results<p>Behavioral tests demonstrated that LPS-induced rats exhibited significant depressive-like behaviors, including reduced sucrose preference, decreased activity levels in the open field, and restricted exploratory behavior in the elevated plus maze. taVNS intervention significantly alleviated these depressive-like behaviors. …”
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6392
Image 4_Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in...
Published 2025“…</p>Results<p>Behavioral tests demonstrated that LPS-induced rats exhibited significant depressive-like behaviors, including reduced sucrose preference, decreased activity levels in the open field, and restricted exploratory behavior in the elevated plus maze. taVNS intervention significantly alleviated these depressive-like behaviors. …”
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6393
Image 1_Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in...
Published 2025“…</p>Results<p>Behavioral tests demonstrated that LPS-induced rats exhibited significant depressive-like behaviors, including reduced sucrose preference, decreased activity levels in the open field, and restricted exploratory behavior in the elevated plus maze. taVNS intervention significantly alleviated these depressive-like behaviors. …”
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6394
Image 7_Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in...
Published 2025“…</p>Results<p>Behavioral tests demonstrated that LPS-induced rats exhibited significant depressive-like behaviors, including reduced sucrose preference, decreased activity levels in the open field, and restricted exploratory behavior in the elevated plus maze. taVNS intervention significantly alleviated these depressive-like behaviors. …”
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6395
Image 3_Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in...
Published 2025“…</p>Results<p>Behavioral tests demonstrated that LPS-induced rats exhibited significant depressive-like behaviors, including reduced sucrose preference, decreased activity levels in the open field, and restricted exploratory behavior in the elevated plus maze. taVNS intervention significantly alleviated these depressive-like behaviors. …”
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6396
Table 1_Burn inhalation injury and intubation with dexamethasone-eluting endotracheal tubes modulate local microbiome and alter airway inflammation.xlsx
Published 2025“…Differential abundance analysis demonstrated significant positive log fold changes in genera such as Bergeriella, Peptostreptococcus, and Bacteriodes with thermal injury over time. …”
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6397
Data Sheet 1_What regulates decomposition in agroecosystems? Insights from reading the tea leaves.pdf
Published 2025“…No-tillage increased, but perennial cropping decreased, the rate of rooibos tea decomposition (C:N = 50.1). …”
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6398
Data Sheet 3_Epidemiology of inflammatory bowel disease-associated anemia in children and adolescents from 1990 to 2021: a global, regional analysis from the Global Burden of Disea...
Published 2025“…</p>Conclusion<p>The ASPR of IBD-associated anemia in children and adolescents increased from 2005 to 2010 and then decreased after reaching a peak in 2010. In the future, IBD-associated anemia will continue to pose a significant public health problem.…”
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6399
Data Sheet 2_Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence.pdf
Published 2025“…Metabolite analysis revealed associations between decreased proline, isoleucine, valine, and alanine levels with IS. …”
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6400
Data Sheet 1_Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence.pdf
Published 2025“…Metabolite analysis revealed associations between decreased proline, isoleucine, valine, and alanine levels with IS. …”