Showing 17,461 - 17,480 results of 21,342 for search '(( significant challenge decrease ) OR ( significant decrease decrease ))', query time: 0.51s Refine Results
  1. 17461

    Data Sheet 2_Effects and safety of Salvia miltiorrhiza on the improvement of renal function, inflammatory factors, and vascular endothelium in patients with diabetic kidney disease... by Shuyu Zheng (5570231)

    Published 2025
    “…Notably, the safety profile remained sound, with no significant differences in adverse event rates between the two groups (P > 0.05).…”
  2. 17462

    Presentation_1_Multifaceted neuroprotective approach of Trolox in Alzheimer's disease mouse model: targeting Aβ pathology, neuroinflammation, oxidative stress, and synaptic dysfunc... by Muhammad Tahir (741682)

    Published 2024
    “…This research study is significant as it aims to assess the neuroprotective properties of vitamin E (VE) analog Trolox in an Aβ<sub>1 − 42</sub>-induced AD mouse model. …”
  3. 17463

    Table 1_RPL41 inhibits the proliferation and migration of retinoblastoma through the ARL5B-associated lysosomal trafficking.xlsx by Ye Li (290115)

    Published 2025
    “…ARL5B expression was significantly downregulated in treated Y79 and Weri-RB1 cells. …”
  4. 17464

    Data Sheet 1_Deep learning-based image reconstruction benefits diffusion tensor imaging for assessing severity of depression.docx by Yuanyuan Cui (276987)

    Published 2025
    “…</p>Results<p>Twenty-eight patients with mild-to-moderate depression and 24 with severe depression were included. No significant differences were observed between the two groups in terms of gender (p = 0.115), age (p = 0.603), or educational background (p = 0.148). …”
  5. 17465

    Table 2_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.docx by Tien Le (634791)

    Published 2025
    “…Crim1 encodes a type I transmembrane protein that is expressed at the cell membrane of lens epithelial and fiber cells at the stage of lens pit formation. Decreased Crim1 expression in the mouse reduced the number of lens epithelial cells and caused defective adhesion between lens epithelial cells and between the epithelial and fiber cells.…”
  6. 17466

    Table 1_Real-world first-line serplulimab therapy for advanced esophageal cancer: effectiveness, safety, and clinical implications.docx by Fei Yan (128878)

    Published 2025
    “…Objective<p>The phase III ASTRUM-007 trial demonstrated significant clinical benefit in patients with PD-L1-positive esophageal squamous cell carcinoma (ESCC) treated with first-line serplulimab plus chemotherapy. …”
  7. 17467

    Table 1_Eculizumab is efficacious and safe in pediatric patients with various forms of hemolytic uremic syndrome: a retrospective clinical experience of a tertiary center.docx by Naama Lax (20998004)

    Published 2025
    “…TMA event-free status was reached in 15 (63%) patients. Significant improvements were observed in platelet count (63%), lactate dehydrogenase levels (76% within the first week), hemoglobin (60%), and estimated glomerular filtration rate (79%); while CH-50 levels decreased. …”
  8. 17468

    Data Sheet 1_Global, regional, and national burden of musculoskeletal disorders, 1990–2021: an analysis of the global burden of disease study 2021 and forecast to 2035.pdf by Meizhi Liu (21898892)

    Published 2025
    “…Frontier analysis revealed significant gaps between current burdens and achievable benchmarks, particularly in high-SDI regions, while some low-SDI regions demonstrated effective management despite limited resources. …”
  9. 17469

    Table 1_The effect of khat chewing on sexual desire among adults in North East Ethiopia: a propensity score-match analysis.docx by Temesgen Gebeyehu Wondmeneh (9716120)

    Published 2025
    “…Background<p>Although the number of khat chewers has increased from time to time in Ethiopia, the direction (increased or decreased) of khat chewing on sexual desire is not well known due to the absence of adequate studies. …”
  10. 17470

    Table1_Causal association between matrix metalloproteinases and diabetic neuropathy: a two-sample Mendelian randomization study.docx by Chao Bai (4428472)

    Published 2025
    “…Objective<p>Diabetic neuropathy (DN), a common and debilitating complication of diabetes, significantly impairs the quality of life of affected individuals. …”
  11. 17471

    Table 1_From lockdown to recovery: changing patterns of viral infection severity in a pediatric cohort with asthma.docx by Cassidy Jones (22301638)

    Published 2025
    “…RV/EV was the most common virus during all periods. Viral incidence decreased during NPIs but rebounded post-NPI with unusual seasonality. mWHO OSI scores declined over time (pre-NPI: 2.98; NPI: 2.49; post-NPI: 2.28), with significant reductions in hospitalizations, PICU admissions, and oxygen use (p < 0.0001). …”
  12. 17472

    <b>Species richness, composition and dominance of core and climate relicts of African Miombo woodlands</b> by Justice Muvengwi (22631075)

    Published 2025
    “…Significant differences in species composition were observed between sites, with the most pronounced dissimilarities between the core miombo woodland and Mozambique relict. …”
  13. 17473

    Table 2_Survival assessment in extremely preterm neonates in a middle-income setting.docx by Maria J. Rodriguez-Sibaja (17456689)

    Published 2025
    “…Notably, survival after extremely preterm birth was associated with significant morbidity.</p>…”
  14. 17474

    Table_1_Association between the Planetary Health Diet Index and biological aging among the U.S. population.DOCX by Shaoqun Huang (19810725)

    Published 2024
    “…</p>Conclusion<p>Our study explored a significant correlation between PHDI and biological aging, indicating that adherence to PHD may prevent biological aging.…”
  15. 17475

    Image 1_STZ-induced hyperglycemia differentially influences mitochondrial distribution and morphology in the habenulointerpeduncular circuit.tiff by Mohammad Jodeiri Farshbaf (20466956)

    Published 2024
    “…Introduction<p>Diabetes is a metabolic disorder of glucose homeostasis that is a significant risk factor for neurodegenerative diseases, such as Alzheimer’s disease, as well as mood disorders, which often precede neurodegenerative conditions. …”
  16. 17476

    Data - <i>trus</i>RNAi wing size measurement. by Saeko Takada (21616085)

    Published 2025
    “…In mutant larvae, we found decreased cell proliferation and growth defects in the brain and imaginal discs. …”
  17. 17477

    Table 1_Methodological approaches to survey complex ice cave environments - the case of Dobšiná (Slovakia).docx by Katarína Pukanská (20431835)

    Published 2024
    “…</p>Results<p>Between 2018 and 2023, the ice volume in certain sections of the cave decreased by up to 667 m³, with notable reductions in ice thickness ranging from 0.3 to 0.9 m in areas like the Small Hall and Collapsed Dome. …”
  18. 17478

    Image5_Hypoxia-induced PD-L1 expression and modulation of muscle stem cell allograft rejection.JPEG by Jacob Raiten (20021262)

    Published 2024
    “…In vivo, these preconditioned MuSCs led to decreased infiltration of CD4<sup>+</sup> and CD8<sup>+</sup> T cells in implanted limb muscles of mouse models. …”
  19. 17479

    Characteristics of children in the study. by Shijie Yu (511369)

    Published 2025
    “…</p><p>Conclusions:</p><p>This study found a significant association between myopia and worse HRQOL in primary and secondary school children. …”
  20. 17480

    Table 1_Obinutuzumab in systemic lupus erythematosus: a real-world experience.docx by Chunmei Wu (3202050)

    Published 2025
    “…Among 15 lupus nephritis patients, 86.7% achieved complete renal response. Significant hematologic improvement was observed in autoimmune hemolytic anemia and thrombocytopenia. …”