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challenge » challenges (Expand Search)
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19621
DataSheet_1_RETRACTED: Tregs depletion aggravates activation of astrocytes by modulating IL-10/GXP4 following cerebral infarction.docx
Published 2024“…</p>Results<p>In the tMCAO mouse model, depletion of tregs protected against activation of astrocyte and significantly decreased FSP1, IL-6, IL-2, and NLRP3 expression levels, while partially reversing the changes in Tregs. …”
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19622
Impact of Carbene Ligands on the Properties and Reactivity of Diazoboranes
Published 2025“…The results demonstrate that increasing carbene π-acidity weakens the B–N bond while strengthening the N–N bond, significantly decreasing thermal stability. Kinetic studies reveal that less π-acidic carbenes promote a second-order decay mechanism, leading to dibora-azine formation, whereas more π-acidic carbenes favor first-order dinitrogen dissociation, facilitating borylene generation. …”
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19623
Table 8_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.xlsx
Published 2025“…Wheat seed inoculation significantly enhanced germination metrics, seedling vigor, and altered carbohydrate metabolism in the seed endosperm. …”
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19624
Data Sheet 14_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.pdf
Published 2025“…We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”
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19625
Data Sheet 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.xlsx
Published 2025“…</p>Results<p>Alirocumab significantly improved spatial working memory, restored hippocampal long-term potentiation, and normalized synaptophysin expression. …”
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19626
Table 1_Exogenous myo-inositol enhances drought tolerance in maize seedlings by antioxidant defense, and photosynthetic efficiency.docx
Published 2025“…</p>Results<p>The results demonstrate that MI significantly restored growth parameters under drought conditions, increasing shoot and root biomass by 40.74% and 28.30%, respectively, on Day 7. …”
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19627
Image 10_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg
Published 2025“…In vivo, RBM15 depletion significantly delayed tumor progression and enhanced CD8⁺ T cell infiltration and activation in the tumor microenvironment.…”
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19628
Table 1_Integrated multi-omics analysis reveals the mechanisms of naringin in ameliorating high-fat diet-induced metabolic dysfunction-associated steatotic liver disease.doc
Published 2025“…Lipidomic analysis revealed that Nar restored hepatic lipid homeostasis, significantly decreasing levels of TGs and diglycerides (DGs), with 20 differentially abundant lipid species identified as potential biomarkers. …”
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19629
Complexity comparison of different models.
Published 2025“…The computational complexity of the improved model decreased dramatically, but the average classification accuracy was only 1.6% lower than that before the improvement. …”
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19630
Dust particle size distribution.
Published 2025“…Results indicate that installing a return pipe significantly reduces dust overflow caused by impact airflow during blanking. …”
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19631
Image 3_3KO-NSCs ameliorate behavioral deficits and modulate gut microbiota in a VPA-induced C57BL/6 mouse model of autism.tif
Published 2025“…</p>Results<p>3KO-hiPSC-NSC treatment significantly ameliorated VPA-induced ASD-like behaviors. …”
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19632
Data of all figures
Published 2025“…Our findings evidence that SPD significantly ameliorates SALI via the regulation of AMPK-mediated necroptosis. …”
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19633
Image 3_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg
Published 2025“…In vivo, RBM15 depletion significantly delayed tumor progression and enhanced CD8⁺ T cell infiltration and activation in the tumor microenvironment.…”
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19634
Friedman statistic and p-value across iterations.
Published 2025“…However, the model’s robustness decreased when the data structure was shuffled, indicating limited generalization to unseen data. …”
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19635
Table 1_Evaluation of mesenchymal stem cells as an in vitro model for inherited retinal diseases.docx
Published 2024“…In the preclinical research phase, in vitro models complement in vivo models by reducing animal studies, decreasing costs, and shortening research timelines. …”
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19636
Glutamate dehydrogenase 2 is required for virulence by facilitating fungal growth in the host hemocoel
Published 2025“…Loss of <i>MrGDH2</i> function resulted in significantly reduced virulence during both cuticle-passing and cuticle-bypassing infections but did not affect appressorium formation or cuticle penetration. …”
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19637
Image 1_3KO-NSCs ameliorate behavioral deficits and modulate gut microbiota in a VPA-induced C57BL/6 mouse model of autism.tif
Published 2025“…</p>Results<p>3KO-hiPSC-NSC treatment significantly ameliorated VPA-induced ASD-like behaviors. …”
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19638
Dynamic window based median filtering algorithm.
Published 2025“…The computational complexity of the improved model decreased dramatically, but the average classification accuracy was only 1.6% lower than that before the improvement. …”
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19639
Image 7_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.tif
Published 2025“…In vivo, RBM15 depletion significantly delayed tumor progression and enhanced CD8⁺ T cell infiltration and activation in the tumor microenvironment.…”
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19640
Table 1_Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study.docx
Published 2025“…</p>Results<p>Among 67 patients analyzed, LSG significantly decreased serum concentrations of arginine, alanine, threonine, glutamic acid, branched-chain amino acids (valine, isoleucine, leucine), and aromatic amino acids (tyrosine, phenylalanine, tryptophan) (p < 0.05), while serine and glycine increased (p < 0.05). …”