بدائل البحث:
marked decrease » marked increase (توسيع البحث)
challenge » challenges (توسيع البحث)
يعرض 1 - 3 نتائج من 3 نتيجة بحث عن '(( significant challenge decrease ) OR ( significantly ((larger decrease) OR (marked decrease)) ))~', وقت الاستعلام: 0.39s تنقيح النتائج
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    Reliable high-PAP-1-loaded polymeric micelles for cancer therapy: preparation, characterization, and evaluation of anti-tumor efficacy حسب Fang Ye (112854)

    منشور في 2025
    "…Molecular simulations revealed that PAE’s tertiary amine protonation affected the self-assembly process, modifying hydrophobicity and resulting in larger, loosely packed particles. Furthermore, compared to free PAP-1 or PAP-1 combined with MDR inhibitors, PAP-1-loaded micelles significantly enhanced cytotoxicity and apoptosis induction in Jurkat and B16F10 cells, through mechanisms involving decreased mitochondrial membrane potential and elevated caspase-3 activity. …"
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