بدائل البحث:
significant challenges » significant challenge (توسيع البحث), significant changes (توسيع البحث)
significant decrease » significant increase (توسيع البحث), significantly increased (توسيع البحث)
challenges case » challenges pose (توسيع البحث), challenges raised (توسيع البحث), challenges faced (توسيع البحث)
significant challenges » significant challenge (توسيع البحث), significant changes (توسيع البحث)
significant decrease » significant increase (توسيع البحث), significantly increased (توسيع البحث)
challenges case » challenges pose (توسيع البحث), challenges raised (توسيع البحث), challenges faced (توسيع البحث)
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19281
Ubiquitin degradation of the Ribonuclease H2 subunit B Rnh2B regulates the virulence of <i>Cryptococcus neoformans</i>
منشور في 2025"…Research has shown that the absence of Cdc4, an F-box protein in <i>C. neoformans</i>, decreases virulence, yet the mechanisms by which Cdc4 affects these processes remain unclear. …"
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19282
Image_1_Effect of probiotic supplementation combined with bismuth-containing quadruple therapy on gut microbiota during Helicobacter pylori eradication: a randomized, double-blind,...
منشور في 2024"…After treatment, the GSRS score decreased significantly in the probiotic group (p = 0.039). …"
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19283
Image 1_Safety assessment of temozolomidee: real-world adverse event analysis from the FAERS database.png
منشور في 2025"…Notable PTs included *petechiae* (ROR 9.87), *hemiparesis* (ROR 9.36), and *platelet count decreased* (ROR 8.61). Unexpected AEs, such as *pulmonary embolism* (ROR 4.96) and *Pneumocystis jirovecii pneumonia* (ROR 7.09), were identified. …"
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19284
Data Sheet 1_Interstitial fluid transport in linea alba is involved in acupuncture-induced attenuation of ovarian hypofunction in aged rats.pdf
منشور في 2025"…Background<p>Age-related ovarian dysfunction, characterized by declining follicular reserve and hormonal imbalance, poses a significant challenge in reproductive endocrinology, severely compromising fertility and quality of life. …"
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19285
Table 1_Interleukin-26 expression in tuberculosis disease and its regulatory effect in macrophage polarization and intracellular elimination of Mycobacterium tuberculosis.docx
منشور في 2024"…In this study, we observed significantly elevated IL-26 mRNA expression in peripheral blood mononuclear cells of active-TB patients compared to healthy individuals. …"
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19286
Research framework.
منشور في 2025"…The results indicated that from 1990 to 2020, the area of unused land in the Shiyang River Basin decreased the most, mainly converted into farmland, construction land, and water areas. …"
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19287
Post-traumatic stress disorder in German youth: representative claims data pre- vs. intra-COVID-19-pandemic
منشور في 2025"…Hospitalisations among female adolescents only decreased for those with low SES (OR = 0.67 [0.38, 1.19]).…"
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19288
Supplementary Material for: WHOverlap Multicenter Study: Dissecting the Insufficient/Inadequate/Non-Diagnostic Category and Its Overlap with the Benign Category in the WHO Reportin...
منشور في 2025"…Introduction: Distinguishing between Non-Diagnostic (ND) and Benign (B) categories in lung cytopathology remains clinically challenging, especially given the significant overlap and the high risk of malignancy (ROM) often reported for ND cases. …"
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19289
Data Sheet 1_Analysis of pharmacotherapeutic approaches for multiple myeloma and correlated renal and pulmonary impairments: a retrospective real-world registry study in the Greate...
منشور في 2025"…Background<p>Multiple myeloma (MM) is a plasma cell malignancy with significant unmet medical needs, particularly in the treatment of relapsed and refractory disease. …"
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19290
Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario
منشور في 2025"…<p>Preeclampsia (PE) is characterized by systemic endothelial dysfunction and remains a significant clinical challenge. Activation of NLRP3 inflammasome, reactive oxygen species (ROS) production, and pyroptosis and autophagy are important mechanisms in this condition. …"
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19291
Data_Sheet_1_Banxia-Yiyiren alleviates insomnia and anxiety by regulating the gut microbiota and metabolites of PCPA-induced insomnia model rats.zip
منشور في 2024"…Additionally, there was a significant Pearson correlation between the genus-level differences in the gut microbiota and the differentially abundant metabolites among the G1–G2, G3–G2, and G6–G2 groups.…"
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19292
Data Sheet 2_Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy.docx
منشور في 2025"…The levels of pro-inflammatory cytokines in blood were also significantly decreased in shPD-L1 treated mice. Additionally, T cell apoptosis rates in the spleen showed a 2-fold increase in treated mice. …"
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19293
Data Sheet 1_Risk factors of low bone mass in young patients with transfusion-dependent beta-thalassemia.docx
منشور في 2025"…Without height-adjusted BMD correction, the overall prevalence was 31.6% (33.4% in the 5-19-year subgroup), which significantly decreased to 15.8% in the 5-19-year subgroup after height-adjusted correction, highlighting that traditional BMD assessments may overestimate risk due to unaccounted short stature. …"
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19294
Data Sheet 1_Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy.pdf
منشور في 2025"…The levels of pro-inflammatory cytokines in blood were also significantly decreased in shPD-L1 treated mice. Additionally, T cell apoptosis rates in the spleen showed a 2-fold increase in treated mice. …"
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19295
Highly Sensitive and Selective Electrochemical Sensor via Cu-BTC/Au@Cu-BTC Modified Screen-Printed Electrode for the Detection of Chemical Agents
منشور في 2025"…Chemical agents present significant threat to international peace, security, and human health due to their potential toxicity. …"
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19296
Data Sheet 1_Efficacy and mechanism of cyprosulfamide in alleviating the phytotoxicity of clomazone residue on maize seedling.docx
منشور في 2024"…Introduction<p>The residues of clomazone (Clo) can lead to phytotoxic symptoms such as foliar bleaching, reduced plant height, and decreased maize yields. Herbicide safener represent one of the most economically efficient strategies for mitigating herbicide-induced damage.…"
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19297
Data Sheet 1_Addressing common biases in the evaluation of lifetime alcohol consumption patterns and dementia risk: the EPIC-Spain dementia cohort.pdf
منشور في 2025"…</p>Conclusions<p>In this large prospective cohort with over 1,100 dementia cases and long-term follow-up, alcohol consumption was not significantly associated with dementia risk. …"
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19298
Supplementary file 1_Addressing common biases in the evaluation of lifetime alcohol consumption patterns and dementia risk: the EPIC-Spain dementia cohort.pdf
منشور في 2025"…</p>Conclusions<p>In this large prospective cohort with over 1,100 dementia cases and long-term follow-up, alcohol consumption was not significantly associated with dementia risk. …"
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19299
Supplementary Material for: Intraoperative Cortical Indocyanine Green Extravasation as a Predictor of Cerebral Hyperperfusion following Direct Revascularization for Moyamoya Diseas...
منشور في 2025"…However, intraoperative identification of the local vasogenic edema remains challenging. To address this, we implemented a prolonged observation of indocyanine green videoangiography (ICG-VAG) as an extension of routine clinical practice. …"
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19300
Supplementary file 1_Long-term trends in the burden of multiple myeloma in China: a Joinpoint regression and age-period-cohort analysis based on GBD 2021.docx
منشور في 2025"…</p>Results<p>It is estimated that in 2021, there were 17,250 new cases of MM in China, with 47,004 cases and 12,984 deaths. …"