يعرض 19,281 - 19,300 نتائج من 23,503 نتيجة بحث عن '(( significant challenges case ) OR ( significant decrease decrease ))', وقت الاستعلام: 0.43s تنقيح النتائج
  1. 19281

    Ubiquitin degradation of the Ribonuclease H2 subunit B Rnh2B regulates the virulence of <i>Cryptococcus neoformans</i> حسب Meng-Ru Guo (21375491)

    منشور في 2025
    "…Research has shown that the absence of Cdc4, an F-box protein in <i>C. neoformans</i>, decreases virulence, yet the mechanisms by which Cdc4 affects these processes remain unclear. …"
  2. 19282
  3. 19283

    Image 1_Safety assessment of temozolomidee: real-world adverse event analysis from the FAERS database.png حسب Yu Liu (6938)

    منشور في 2025
    "…Notable PTs included *petechiae* (ROR 9.87), *hemiparesis* (ROR 9.36), and *platelet count decreased* (ROR 8.61). Unexpected AEs, such as *pulmonary embolism* (ROR 4.96) and *Pneumocystis jirovecii pneumonia* (ROR 7.09), were identified. …"
  4. 19284

    Data Sheet 1_Interstitial fluid transport in linea alba is involved in acupuncture-induced attenuation of ovarian hypofunction in aged rats.pdf حسب Yaoyao Zhu (3487937)

    منشور في 2025
    "…Background<p>Age-related ovarian dysfunction, characterized by declining follicular reserve and hormonal imbalance, poses a significant challenge in reproductive endocrinology, severely compromising fertility and quality of life. …"
  5. 19285

    Table 1_Interleukin-26 expression in tuberculosis disease and its regulatory effect in macrophage polarization and intracellular elimination of Mycobacterium tuberculosis.docx حسب Kaisong Huang (5412626)

    منشور في 2024
    "…In this study, we observed significantly elevated IL-26 mRNA expression in peripheral blood mononuclear cells of active-TB patients compared to healthy individuals. …"
  6. 19286

    Research framework. حسب Wanzhuang Huang (17357306)

    منشور في 2025
    "…The results indicated that from 1990 to 2020, the area of unused land in the Shiyang River Basin decreased the most, mainly converted into farmland, construction land, and water areas. …"
  7. 19287

    Post-traumatic stress disorder in German youth: representative claims data pre- vs. intra-COVID-19-pandemic حسب Jule Leickert (21598275)

    منشور في 2025
    "…Hospitalisations among female adolescents only decreased for those with low SES (OR = 0.67 [0.38, 1.19]).…"
  8. 19288

    Supplementary Material for: WHOverlap Multicenter Study: Dissecting the Insufficient/Inadequate/Non-Diagnostic Category and Its Overlap with the Benign Category in the WHO Reportin... حسب figshare admin karger (2628495)

    منشور في 2025
    "…Introduction: Distinguishing between Non-Diagnostic (ND) and Benign (B) categories in lung cytopathology remains clinically challenging, especially given the significant overlap and the high risk of malignancy (ROM) often reported for ND cases. …"
  9. 19289

    Data Sheet 1_Analysis of pharmacotherapeutic approaches for multiple myeloma and correlated renal and pulmonary impairments: a retrospective real-world registry study in the Greate... حسب Ayman Alhejazi (21092054)

    منشور في 2025
    "…Background<p>Multiple myeloma (MM) is a plasma cell malignancy with significant unmet medical needs, particularly in the treatment of relapsed and refractory disease. …"
  10. 19290

    Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario حسب Karoliny Nune Santos (21752603)

    منشور في 2025
    "…<p>Preeclampsia (PE) is characterized by systemic endothelial dysfunction and remains a significant clinical challenge. Activation of NLRP3 inflammasome, reactive oxygen species (ROS) production, and pyroptosis and autophagy are important mechanisms in this condition. …"
  11. 19291

    Data_Sheet_1_Banxia-Yiyiren alleviates insomnia and anxiety by regulating the gut microbiota and metabolites of PCPA-induced insomnia model rats.zip حسب Liang Wang (23021)

    منشور في 2024
    "…Additionally, there was a significant Pearson correlation between the genus-level differences in the gut microbiota and the differentially abundant metabolites among the G1–G2, G3–G2, and G6–G2 groups.…"
  12. 19292

    Data Sheet 2_Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy.docx حسب Wenjun Li (41954)

    منشور في 2025
    "…The levels of pro-inflammatory cytokines in blood were also significantly decreased in shPD-L1 treated mice. Additionally, T cell apoptosis rates in the spleen showed a 2-fold increase in treated mice. …"
  13. 19293

    Data Sheet 1_Risk factors of low bone mass in young patients with transfusion-dependent beta-thalassemia.docx حسب Wei Zhang (405)

    منشور في 2025
    "…Without height-adjusted BMD correction, the overall prevalence was 31.6% (33.4% in the 5-19-year subgroup), which significantly decreased to 15.8% in the 5-19-year subgroup after height-adjusted correction, highlighting that traditional BMD assessments may overestimate risk due to unaccounted short stature. …"
  14. 19294

    Data Sheet 1_Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy.pdf حسب Wenjun Li (41954)

    منشور في 2025
    "…The levels of pro-inflammatory cytokines in blood were also significantly decreased in shPD-L1 treated mice. Additionally, T cell apoptosis rates in the spleen showed a 2-fold increase in treated mice. …"
  15. 19295

    Highly Sensitive and Selective Electrochemical Sensor via Cu-BTC/Au@Cu-BTC Modified Screen-Printed Electrode for the Detection of Chemical Agents حسب Xiaosen Li (6263651)

    منشور في 2025
    "…Chemical agents present significant threat to international peace, security, and human health due to their potential toxicity. …"
  16. 19296

    Data Sheet 1_Efficacy and mechanism of cyprosulfamide in alleviating the phytotoxicity of clomazone residue on maize seedling.docx حسب Lanlan Sun (1798921)

    منشور في 2024
    "…Introduction<p>The residues of clomazone (Clo) can lead to phytotoxic symptoms such as foliar bleaching, reduced plant height, and decreased maize yields. Herbicide safener represent one of the most economically efficient strategies for mitigating herbicide-induced damage.…"
  17. 19297

    Data Sheet 1_Addressing common biases in the evaluation of lifetime alcohol consumption patterns and dementia risk: the EPIC-Spain dementia cohort.pdf حسب José M. Huerta (4229557)

    منشور في 2025
    "…</p>Conclusions<p>In this large prospective cohort with over 1,100 dementia cases and long-term follow-up, alcohol consumption was not significantly associated with dementia risk. …"
  18. 19298

    Supplementary file 1_Addressing common biases in the evaluation of lifetime alcohol consumption patterns and dementia risk: the EPIC-Spain dementia cohort.pdf حسب José M. Huerta (4229557)

    منشور في 2025
    "…</p>Conclusions<p>In this large prospective cohort with over 1,100 dementia cases and long-term follow-up, alcohol consumption was not significantly associated with dementia risk. …"
  19. 19299

    Supplementary Material for: Intraoperative Cortical Indocyanine Green Extravasation as a Predictor of Cerebral Hyperperfusion following Direct Revascularization for Moyamoya Diseas... حسب figshare admin karger (2628495)

    منشور في 2025
    "…However, intraoperative identification of the local vasogenic edema remains challenging. To address this, we implemented a prolonged observation of indocyanine green videoangiography (ICG-VAG) as an extension of routine clinical practice. …"
  20. 19300

    Supplementary file 1_Long-term trends in the burden of multiple myeloma in China: a Joinpoint regression and age-period-cohort analysis based on GBD 2021.docx حسب Yanyu Zhang (281806)

    منشور في 2025
    "…</p>Results<p>It is estimated that in 2021, there were 17,250 new cases of MM in China, with 47,004 cases and 12,984 deaths. …"