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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
challenges decrease » challenges case (Expand Search)
changes decrease » larger decrease (Expand Search), change increases (Expand Search)
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6301
Data Sheet 2_Identification of the malonylation modification in Staphylococcus aureus and insight into the regulators in biofilm formation.xlsx
Published 2025“…</p>Results<p>Quantitative profiling identified 2,833 malonylated sites across 788 proteins, with significant enrichment in biofilm-associated proteins. …”
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6302
Supplementary Material for: Adjuvant Lip Gauze Wet Dressing Restores Lip Barrier Function and Improves Atopic Cheilitis
Published 2025“…Results indicated that patients exhibited decreased lip barrier function, which improved significantly with gauze wet dressing, enhancing hydration and normalizing pH levels within 30 minutes. …”
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6303
Table 1_High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota.xlsx
Published 2025“…Furthermore, oral administration of high-dose thiamine also regulated HFFD-induced gut microbiota dysbiosis by reshaping its structure and composition of gut microbiota, such as increasing the relative abundance of Actinobacteria and Bifidobacterium pseudolongum, and reducing the relative abundance of Proteobacteria and Ruminococcus gnavus, accompanied by decreased level of gut-derived endotoxin. Finally, significant correlations were found between obesity-related phenotypes and gut microbiota through correlation analysis.…”
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6304
Data Sheet 1_Comprehensive analysis on the regulatory mechanism of active ingredient accumulation during fermentation process of Massa Medicata Fermentata: microbe and metabolic pr...
Published 2025“…In this study, we aimed to investigate the dynamic changes and correlations of physicochemical properties, microbial communities, and metabolite profiles in different fermentation stages (0, 48, 72, and 96 h) of MMF.…”
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6305
Data_Sheet_1_Efficacy of transcranial magnetic stimulation treatment in reducing neuropsychiatric symptomatology after traumatic brain injury.PDF
Published 2024“…After 4 weeks, impulsivity further declined, though no other significant changes were noted. At 8 weeks, a persistent positive effect was observed, including enhanced positive emotions.…”
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6306
Data Sheet 1_In vivo profiling of the PE/PPE proteins of Mycobacterium tuberculosis reveals diverse contributions to virulence.pdf
Published 2025“…We found consistent, time-dependent changes in mutant abundance across our animal replicates and identified decreases in several key mutant strains known to promote bacterial growth or virulence. …”
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6307
Table 1_Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.docx
Published 2025“…</p>Results<p>Mice lacking Bmi1 versus WT exposed to hyperoxia exhibited hallmarks of human acute lung injury (ALI) such as increased lung permeability, alveolar edema, hemorrhage, interstitial thickening, and infiltration of immune cells; and alterations in lung mechanics, including increased elastance and decreased lung compliance.</p>Discussion<p>Bmi1<sup>−/−</sup> mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to WT mice. …”
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6308
Image 11_Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.tif
Published 2025“…</p>Results<p>Mice lacking Bmi1 versus WT exposed to hyperoxia exhibited hallmarks of human acute lung injury (ALI) such as increased lung permeability, alveolar edema, hemorrhage, interstitial thickening, and infiltration of immune cells; and alterations in lung mechanics, including increased elastance and decreased lung compliance.</p>Discussion<p>Bmi1<sup>−/−</sup> mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to WT mice. …”
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6309
Table 8_The impact of Helicobacter pylori infection and eradication therapies on gut microbiota: a systematic review of microbial dysbiosis and its implications in gastric carcinog...
Published 2025“…</p>Results<p>A total of 45 studies met the inclusion criteria, which evaluated microbial changes in H. pylori -infected individuals before and after eradication therapies. …”
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6310
Presentation 1_Combination of αCD4 antibody and retinal antigen injection induces long-term disease control in autoimmune uveitis.pptx
Published 2025“…Flow cytometry was employed to analyze immune cell infiltration, and RNA sequencing of ocular tissue was performed to assess gene expression changes.</p>Results<p>Mice receiving aCD4 antibody and IRBP1-20 showed sustained disease control up to 28 weeks, with reduced ocular inflammation, less retinal damage on OCT, and decreased immune cell infiltration compared to untreated controls. …”
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6311
Table 3_Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.xlsx
Published 2025“…The lactylation levels of Mtatp8, Atp5mg, and Atp5po proteins in the exercise group were significantly decreased, while their protein levels were significantly increased. …”
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6312
Table9_Dynamics of flavonoid metabolites in coconut water based on metabolomics perspective.xlsx
Published 2024“…The total flavonoid content in both types of coconut water exhibited a decreasing trend with developmental progression, but the total flavonoid content in CK was significantly higher than that in W5. …”
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6313
Presentation 1_Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.pptx
Published 2025“…</p>Results<p>Mice lacking Bmi1 versus WT exposed to hyperoxia exhibited hallmarks of human acute lung injury (ALI) such as increased lung permeability, alveolar edema, hemorrhage, interstitial thickening, and infiltration of immune cells; and alterations in lung mechanics, including increased elastance and decreased lung compliance.</p>Discussion<p>Bmi1<sup>−/−</sup> mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to WT mice. …”
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6314
Image 1_Global burden of endometriosis from 1990 to 2021 and projections to 2050: a comprehensive analysis based on the global burden of disease study 2021.tif
Published 2025“…Future research should investigate the effects of population aging and lifestyle changes on the burden of EMT.</p>…”
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6315
Table7_Dynamics of flavonoid metabolites in coconut water based on metabolomics perspective.xlsx
Published 2024“…The total flavonoid content in both types of coconut water exhibited a decreasing trend with developmental progression, but the total flavonoid content in CK was significantly higher than that in W5. …”
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6316
Image 3_Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.tif
Published 2025“…The lactylation levels of Mtatp8, Atp5mg, and Atp5po proteins in the exercise group were significantly decreased, while their protein levels were significantly increased. …”
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6317
Table 1_Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.xlsx
Published 2025“…The lactylation levels of Mtatp8, Atp5mg, and Atp5po proteins in the exercise group were significantly decreased, while their protein levels were significantly increased. …”
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6318
Image 3_Global burden of endometriosis from 1990 to 2021 and projections to 2050: a comprehensive analysis based on the global burden of disease study 2021.tif
Published 2025“…Future research should investigate the effects of population aging and lifestyle changes on the burden of EMT.</p>…”
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6319
Table6_Dynamics of flavonoid metabolites in coconut water based on metabolomics perspective.xlsx
Published 2024“…The total flavonoid content in both types of coconut water exhibited a decreasing trend with developmental progression, but the total flavonoid content in CK was significantly higher than that in W5. …”
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6320
original data.xlsx
Published 2024“…<b>Research Results</b>: The results showed that the levels of inflammatory factors significantly decreased in the blood purification treatment group after treatment, with a notable reduction in hospitalization and ICU stay duration compared to the conventional treatment group. …”