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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
challenges decrease » challenges case (Expand Search)
changes decrease » larger decrease (Expand Search), change increases (Expand Search)
largest decrease » larger decrease (Expand Search), marked decrease (Expand Search)
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6341
Image 1_Entropy as a marker of physiological transition during pediatric cardiopulmonary exercise testing.jpeg
Published 2025“…In addition to sex and age group comparisons, we examined SampEn before and after the midpoint of each participant’s CPET to assess how SampEn changes as exercise intensity increases. We corroborated previous findings that SampEn decreases in the later half of CPET for healthy pediatric participants for oxygen uptake (V̇O2), carbon dioxide output (V̇CO2), ventilation (V̇E), and heart rate (HR). …”
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6342
Image 10_Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.tif
Published 2025“…</p>Results<p>Mice lacking Bmi1 versus WT exposed to hyperoxia exhibited hallmarks of human acute lung injury (ALI) such as increased lung permeability, alveolar edema, hemorrhage, interstitial thickening, and infiltration of immune cells; and alterations in lung mechanics, including increased elastance and decreased lung compliance.</p>Discussion<p>Bmi1<sup>−/−</sup> mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to WT mice. …”
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6343
Table 1_Effects of quantitative marinating on meat quality, biogenic amines, and flavor compounds in crayfish meat.docx
Published 2025“…The levels of biogenic amines of tryptamine, phenethylamine, and histamine in QM decreased significantly compared with SG (P < 0.05). …”
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6344
Image 8_Bmi1 deficiency exacerbates hyperoxia-induced acute lung injury in mice.tif
Published 2025“…</p>Results<p>Mice lacking Bmi1 versus WT exposed to hyperoxia exhibited hallmarks of human acute lung injury (ALI) such as increased lung permeability, alveolar edema, hemorrhage, interstitial thickening, and infiltration of immune cells; and alterations in lung mechanics, including increased elastance and decreased lung compliance.</p>Discussion<p>Bmi1<sup>−/−</sup> mice exhibit increased mitochondrial damage, increased oxidative stress, and significant changes in protein markers related to mitophagy compared to WT mice. …”
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6345
Table5_Dynamics of flavonoid metabolites in coconut water based on metabolomics perspective.xlsx
Published 2024“…The total flavonoid content in both types of coconut water exhibited a decreasing trend with developmental progression, but the total flavonoid content in CK was significantly higher than that in W5. …”
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6346
Image1_Dynamics of flavonoid metabolites in coconut water based on metabolomics perspective.png
Published 2024“…The total flavonoid content in both types of coconut water exhibited a decreasing trend with developmental progression, but the total flavonoid content in CK was significantly higher than that in W5. …”
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6347
Image 2_Entropy as a marker of physiological transition during pediatric cardiopulmonary exercise testing.jpeg
Published 2025“…In addition to sex and age group comparisons, we examined SampEn before and after the midpoint of each participant’s CPET to assess how SampEn changes as exercise intensity increases. We corroborated previous findings that SampEn decreases in the later half of CPET for healthy pediatric participants for oxygen uptake (V̇O2), carbon dioxide output (V̇CO2), ventilation (V̇E), and heart rate (HR). …”
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6348
Table4_Dynamics of flavonoid metabolites in coconut water based on metabolomics perspective.xlsx
Published 2024“…The total flavonoid content in both types of coconut water exhibited a decreasing trend with developmental progression, but the total flavonoid content in CK was significantly higher than that in W5. …”
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6349
Supplemental Tables S1-S5
Published 2025“…These findings indicate that a single day of reduced physical activity can elicit modest but significant changes in the metabolic and transcriptomic exercise response. …”
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6350
Table 6_The impact of Helicobacter pylori infection and eradication therapies on gut microbiota: a systematic review of microbial dysbiosis and its implications in gastric carcinog...
Published 2025“…</p>Results<p>A total of 45 studies met the inclusion criteria, which evaluated microbial changes in H. pylori -infected individuals before and after eradication therapies. …”
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6351
Table 1_Effect of Lactobacillus rhamnosus AB-GG combined with phototherapy on neonatal jaundice indicators, intestinal microbiota and metabolism.docx
Published 2025“…This study also observed that the metabolic composition structures of both groups underwent changes before and after phototherapy. However, no significantly differential metabolites were identified when the groups were compared at different time points.…”
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6352
Supplementary file 1_Saltmarsh reclamation enhances plant species richness and reduces soil macrofaunal biomass by regulating soil properties through elevation.docx
Published 2025“…<p>Globally, saltmarsh reclamation results in significant losses of coastal wetlands. However, the impacts on above- and below-ground biodiversity and the underlying mechanisms remain poorly understood. …”
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6353
Table 2_The impact of Helicobacter pylori infection and eradication therapies on gut microbiota: a systematic review of microbial dysbiosis and its implications in gastric carcinog...
Published 2025“…</p>Results<p>A total of 45 studies met the inclusion criteria, which evaluated microbial changes in H. pylori -infected individuals before and after eradication therapies. …”
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6354
Table 4_The impact of Helicobacter pylori infection and eradication therapies on gut microbiota: a systematic review of microbial dysbiosis and its implications in gastric carcinog...
Published 2025“…</p>Results<p>A total of 45 studies met the inclusion criteria, which evaluated microbial changes in H. pylori -infected individuals before and after eradication therapies. …”
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6355
Table 1_Unpacking the cost implications of diagnosis-related groups reform for lumbar disc herniation patients in Chinese medicine: a closer look at evidence from China.xls
Published 2025“…Objectives<p>Lumbar disc herniation (LDH) presents a significant economic burden globally, worsening in China due to an aging population. …”
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6356
Data Sheet 1_Comparison between 75-g and 100-g oral glucose tolerance tests using international association of diabetes and pregnancy study group one-step diagnostic threshold to d...
Published 2025“…However, from fasting to 2h, the 100g group showed a steeper rise than the 75g group [Difference in slope (95% CI):0.412 (0.244 to 0.580), p<0.05], and a slower decline between 1-2h [Difference in slope (95% CI):0.047 (0.010 to 0.084), p<0.05].Glucose-adjusted continuous analysis showed that blood glucose levels were mostly associated with adverse outcomes, with the strength of association gradually decreasing from fasting to 1h and 2h. Both groups exhibited similar trends, no significant differences in the risks of adverse outcomes (expressed as ORs) were observed between the 75g and 100g OGTT groups (all p > 0.05).…”
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6357
Data Sheet 1_Thermophilic microbial agents promote the fermentation progression of spent mushroom compost and pig manure.docx
Published 2025“…Notably, the co-addition of thermophilic microbial agents and SMC reduced persistent ARGs by lg0.45–3.73, significantly decreased the abundances of HPB such as Bacteroides and Treponema, and reduced the enrichment of related metabolic pathways, greatly improving compost quality. …”
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6358
Image 3_Scalability of spheroid-derived small extracellular vesicles production in stirred systems.tif
Published 2025“…Implementing upstream processes in a chemically defined media in stirred-tank bioreactors (STBr) is mandatory to closely control the cell environment, and to scale-up production, but it remains a significant challenge for anchorage-dependent cells.…”
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6359
Data Sheet 1_Spatial–temporal evolution and associated factors of older adult care institutions in Shanghai.xlsx
Published 2025“…Background<p>Shanghai is one of the first Chinese cities to tackle the challenges presented by an aging population. In response, the city has been actively seeking solutions for older adult care within a metropolitan context. …”
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6360
Table 3_Does COVID-19 vaccination affect risk perception and adherence to preventive behaviors? A systematic review and meta-analysis.docx
Published 2025“…Meta-analysis revealed no significant difference in risk perception between vaccinated (70.3, 95% CI 60.8–79.8) and unvaccinated subgroups (70.8, 95% CI 61.9–79.6; I<sup>2</sup> = 17.5%), suggesting limited influence on behavior maintenance.…”