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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
challenges decrease » challenges case (Expand Search)
teer decrease » greater decrease (Expand Search)
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4801
DataSheet1_Effects of mesenchymal stromal cells and human recombinant Nerve Growth Factor delivered by bioengineered human corneal lenticule on an innovative model of diabetic reti...
Published 2024“…In the last years, mesenchymal stromal cells (MSCs) and neurotrophins like Nerve Growth Factor (NGF), have garnered significant attention as innovative therapeutic approaches targeting DR-associated neurodegeneration. …”
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4802
Image 1_Regulation effect of seed priming on sowing rate of direct seeding of rice under salt stress.pdf
Published 2025“…However, the global intensification of soil salinization presents a significant challenge to food security. Increasing sowing rates is a common practice to enhance germination under salt stress, although it leads to higher seed costs. …”
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4803
Table 1_CD9 regulates proliferation, invasion, migration and radioresistance of esophageal squamous cell carcinoma by activating AKT/GSK3β signaling pathway.docx
Published 2025“…Background<p>Radioresistance poses a major therapeutic challenge in ESCC, significantly impacting patient prognosis. …”
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4804
Table 1_Regulation effect of seed priming on sowing rate of direct seeding of rice under salt stress.pdf
Published 2025“…However, the global intensification of soil salinization presents a significant challenge to food security. Increasing sowing rates is a common practice to enhance germination under salt stress, although it leads to higher seed costs. …”
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4805
Zika virus replicates efficiently in the zebrafish model and induces morphological defects.
Published 2024“…<i>N</i> = 3). Data are shown as means ± SEM. **** P ≤ 0.0001; ns = not significant; one-way ANOVA. …”
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4806
Table 1_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx
Published 2025“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”
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4807
Table 4_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx
Published 2025“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”
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4808
Image 1_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.tif
Published 2025“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”
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4809
Table 3_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx
Published 2025“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”
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4810
Table 2_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx
Published 2025“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”
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4811
Broader frequency tuning in auditory cortex of <i>Fmr1</i> KO rats despite unaltered subcortical tuning properties.
Published 2025“…Boxplots dots represent individual multiunit clusters. All other values are means ± SEM. **<i>p</i> < 0.01, ***<i>p</i> < 0.0001, ns = not significant. …”
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4812
Epidural Hydromorphone for Postpartum Pain Management After Vaginal Delivery: A Randomized Clinical Trial
Published 2025“…</p><p><br></p><p dir="ltr"><b>Findings</b></p><p dir="ltr">Epidural hydromorphone demonstrated a statistically significant reduction in postpartum pain scores, a decreased requirement for supplemental analgesics, and enhanced maternal satisfaction. …”
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4813
<i>mig-21</i> sensitizes adult DTCs to polarizing signals.
Published 2025“…A robust “extra turn” defect rate of control on <i>vab-3</i> RNAi (n=38/57) decreases with <i>mig-21(u787)</i> on <i>vab-3</i> RNAi (n=24/65), p < 0.01. …”
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4814
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4815
Heart looping variations in <i>Notch3</i> and <i>Nodal</i> compound mutants.
Published 2025“…</i> Filled and empty arrowheads point to curved and straight outflow tract, respectively. Means and standard deviations are shown. L, Left; LV, left ventricle; n.s., non-significant; R, Right; RV, right ventricle. …”
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4816
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4817
Update on trimethylamine N-oxide (TMAO) as a piezolyte and cryoprotectant: its role in a depth limit for marine fishes and loss from hadal fish during capture
Published 2025“…<p dir="ltr"><b>I</b><b>NTRODUCTION</b></p><p dir="ltr">Trimethylamine N-oxide (TMAO) is a small organic molecule found at osmotically-significant concentrations in many marine animal taxa. …”
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4818
LRIG1 and CDK6 expression in the lateral ventricular wall cells
Published 2025“…Although the <i>Cdk6</i> mRNA decreases significantly in the neuroblasts, the DCX+ neuroblasts still show a lot of td-sfGFP immunoreactivity.…”
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4819
Table 1_Organic and inorganic fertilizers modulate the response of the soil microbiome to salinity stress.docx
Published 2025“…Conversely, the application of NPK fertilizer reduced bacterial richness, alpha diversity and soil multifunctionality by 14.52, 5.83, and 12.34%, respectively, further disrupting the microbial community and making resilience to salinity stress more challenging. Furthermore, NPK fertilization increased bacterial network complexity but decreased its stability. …”
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4820
Image 1_Evaluating two live-attenuated vaccines against Salmonella enterica serovar Reading in turkeys: reduced tissue colonization and cecal tonsil transcriptome responses.pdf
Published 2024“…Salmonella dissemination to the spleen was significantly reduced by both vaccines. Gene expression of intestinal transporters (such as SCNN1B and SLC10A2) and tight junction proteins was significantly decreased in the turkey cecal tonsil transcriptome at 2 DPI with S. …”