يعرض 18,061 - 18,080 نتائج من 18,202 نتيجة بحث عن '(( significant challenges decrease ) OR ( significant ((we decrease) OR (a decrease)) ))', وقت الاستعلام: 0.64s تنقيح النتائج
  1. 18061

    Table 2_Plasma exosomal miRNA expression and gut microbiota dysbiosis are associated with cognitive impairment in Alzheimer’s disease.docx حسب Kaihao Lin (13016658)

    منشور في 2025
    "…</p>Results<p>Four exosomal miRNAs and 14 microbiota taxa, which exhibited differential expression and abundance, respectively, in comparison between AD group and normal cognition group, were identified to be significantly associated with MMSE scores. Notably, the abundance of potential probiotics, including Faecalibacterium prausnitzii, Roseburia intestinalis and Roseburia inulinivorans, which was decreased in AD patients, exhibited positive correlations with specific exosomal miRNAs: Roseburia intestinalis correlated with miR-3120-3p and miR-6529-5p; Roseburia inulinivorans correlated with miR-3120-3p, miR-6529-5p and miR-124-3p; Faecalibacterium prausnitzii correlated with miR-3120-3p.…"
  2. 18062

    Table 1_Regional and age-specific global trends associated with infectious diarrhea in children under 14 years old caused by pathogenic microorganisms in 2021.docx حسب Tuanjie Wang (6619406)

    منشور في 2025
    "…</p>Conclusion<p>Although the global burden of diarrhea has decreased significantly, it is still high in low-income countries and low- and medium-SDI areas, and newborns are at high risk. …"
  3. 18063

    Image 1_The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells.tif حسب Jianguo Zhang (6482)

    منشور في 2025
    "…E2F1 was identified as an upstream regulator of EIF4EBP1, with knockdown of E2F1 significantly decreasing EIF4EBP1 promoter activity and binding. …"
  4. 18064

    Image 1_Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway.jpeg حسب Mouying Du (21398510)

    منشور في 2025
    "…</p>Results<p>In vivo, YHF treatment significantly attenuated RIF, protected renal function, increased miR-210 expression, and decreased the expression of HIF-1α, BNIP3, and NIX in the serum exosomes of UUO rats. …"
  5. 18065

    Image 2_Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway.jpeg حسب Mouying Du (21398510)

    منشور في 2025
    "…</p>Results<p>In vivo, YHF treatment significantly attenuated RIF, protected renal function, increased miR-210 expression, and decreased the expression of HIF-1α, BNIP3, and NIX in the serum exosomes of UUO rats. …"
  6. 18066

    Table 1_Epidemiological characteristics and trends of pre-hospital emergency care in Handan, China from 2011 to 2024.docx حسب Feng Tian (121350)

    منشور في 2025
    "…Over the past 14 years, Handan’s pre-hospital EMS demand increased significantly by 3.11-fold (p < 0.001). The percentages of EMS patients aged 61 to 70 and over 71 years old increased significantly (p < 0.01), in contrast, the percentage of EMS patients aged 21 to 30 and 31 to 40 years old decreased significantly (p < 0.01). …"
  7. 18067

    Table 1_Electroacupuncture improves scopolamine hydrobromide induced dry eye in mice via inhibiting ocular surface inflammation and regulating the HMGB1-related signaling pathways.... حسب Xia Wu (203682)

    منشور في 2025
    "…The levels of HMGB1, RAGE, TLR2, TLR4, and IL-6 were significantly decreased while IL-10 level was significantly increased after EA treatment, indicating that EA may improve dry eye surface inflammation by inhibiting HMGB1-related signaling pathways.…"
  8. 18068

    DSC block and its application network structure. حسب Yingying Liu (360782)

    منشور في 2025
    "…The research focuses on the advantages and problems of residual networks and depth-wise separable convolution modules, designs a new remote sensing image change detection model, and finally sets up experiments for verification. …"
  9. 18069

    Image 1_REDD1 attenuates cholestatic liver fibrosis and suppresses PI3K/AKT/mTOR pathway.jpg حسب Xiaonan Li (340228)

    منشور في 2025
    "…</p>Results<p>RNA sequencing revealed REDD1 was significantly upregulated in BDL-induced fibrotic liver tissue. …"
  10. 18070

    Effects of Feed Enriched with Freshwater Fish Oil on the Nutritional Profile and Growth Performance of Asian Redtail Catfish (Hemibagrus nemurus) Fry حسب Netti Aryani (7007696)

    منشور في 2024
    "…The results showed that feed enrichment with FFO significantly affected the composition of fatty acids, amino acids, growth performance, and survival (p<0.05). …"
  11. 18071

    Effects of Feed Enriched with Freshwater Fish Oil on the Nutritional Profile and Growth Performance of Asian Redtail Catfish (Hemibagrus nemurus) Fry حسب netti aryani (19985907)

    منشور في 2024
    "…The results showed that feed enrichment with FFO significantly affected the composition of fatty acids, amino acids, growth performance, and survival (p<0.05). …"
  12. 18072

    Structural, Morphological and Thermal Properties of Kenaf Microcrystalline Cellulose/Poly (Butylene Adipate-Co-Terephthalate) Films for Packaging Applications حسب Aatikah Meraj (20632855)

    منشور في 2025
    "…Cellulose film could potentially be used as a biodegradable film in food packaging applications.…"
  13. 18073

    Table 1_Alterations in gut–kidney axis indicators and TMAO-related biomarkers in elderly patients with hypertensive nephropathy.xlsx حسب Ziyi Li (349831)

    منشور في 2025
    "…</p>Results<p>The chronic kidney disease group exhibited elevated serum urea and creatinine and reduced eGFR, along with increased levels of KIM-1, NGAL, IL-18, TNF-α, IL-6, NF-κB, and FMO3. Urinary TMAO was significantly decreased in both hypertensive groups, while serum TMAO remained unchanged. …"
  14. 18074

    Image 2_Immunomodulatory effects of probiotic Lactobacillus brevis ZG2488 on SARS-CoV-2 vaccine responses in mice.tif حسب Mengshan Chen (14303892)

    منشور في 2025
    "…</p>Discussion<p>These findings demonstrate that L. brevis ZG2488 enhances the immune response to the SARS-CoV-2 vaccine through synergistic and multi-mechanistic actions, supporting its potential as a probiotic adjuvant strategy.</p>…"
  15. 18075

    The structure of multi-scale residual block [30]. حسب Yingying Liu (360782)

    منشور في 2025
    "…The research focuses on the advantages and problems of residual networks and depth-wise separable convolution modules, designs a new remote sensing image change detection model, and finally sets up experiments for verification. …"
  16. 18076

    The structure of IRAU and Res2Net+ block [22]. حسب Yingying Liu (360782)

    منشور في 2025
    "…The research focuses on the advantages and problems of residual networks and depth-wise separable convolution modules, designs a new remote sensing image change detection model, and finally sets up experiments for verification. …"
  17. 18077

    Image 1_Immunomodulatory effects of probiotic Lactobacillus brevis ZG2488 on SARS-CoV-2 vaccine responses in mice.tif حسب Mengshan Chen (14303892)

    منشور في 2025
    "…</p>Discussion<p>These findings demonstrate that L. brevis ZG2488 enhances the immune response to the SARS-CoV-2 vaccine through synergistic and multi-mechanistic actions, supporting its potential as a probiotic adjuvant strategy.</p>…"
  18. 18078

    S1 File - حسب Shi-jie Wang (18569781)

    منشور في 2025
    "…The results showed that muscle TOR knockdown and endurance exercise significantly increased the climbing speed, climbing endurance, the expression of autophagy related gene 2(ATG2), silent information regulator 2(SIR2), and pparγ coactivator 1(PGC-1α) genes, and superoxide dismutases(SOD) activity, but it decreased the expression of the TOR gene and reactive oxygen species(ROS) level, and it protected the myofibrillar fibers and mitochondria of skeletal muscle in Drosophila on a high-salt diet. …"
  19. 18079

    DataSheet_1_RETRACTED: Macrophages depletion alleviates lung injury by modulating AKT3/GXP4 following ventilator associated pneumonia.docx حسب Youfeng Zhu (2460811)

    منشور في 2024
    "…Depletion of macrophages protected against lung epithelial cells and significantly decreased MMP9, MMP19, FTH, and FTL expression levels and increased GPX4 expression levels, while partially reversing the changes in macrophage. …"
  20. 18080

    Data Sheet 1_Relay intercropped soybean promotes nodules development and nitrogen fixation by root exudates deposition.docx حسب Ping Lin (146330)

    منشور في 2024
    "…Compared with monocropping, the nodule number significantly decreased in relay strip intercropping soybean, and NTS achieved 97% at soybean five trifoliolate stage. …"