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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
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17161
DataSheet1_Effects of total flavonoids of Rhizoma Drynariae on biochemical indicators of bone metabolism: a systematic review and meta-analysis.DOCX
Published 2024“…The tartrate-resistant acid phosphatase (TRACP) decreased significantly (WMD: −1.34; 95% CI: −1.62, −1.06; p < 0.00001). …”
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17162
Image 1_Berberine alleviates atherosclerosis by modulating autophagy and inflammation through the RAGE-NF-κB pathway.tif
Published 2025“…Introduction<p>Lipid accumulation and foam cell formation are significant features that expedite the progression of atherosclerosis (AS). …”
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17163
Supplementary Material for: How the COVID-19 Pandemic Impacted Neurological Hospital Admissions in Germany - A Retrospective Analysis
Published 2025“…While overall admissions decreased, average case severity was significantly higher. …”
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17164
Data Sheet 1_Burden of NASH related liver cancer from 1990 to 2021 at the global, regional, and national levels.pdf
Published 2025“…At the national level, ASRs consistently decreased with higher SDI.</p>Conclusion<p>This study highlights the substantial burden of NRLC at global, regional, and national levels. …”
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17165
Video 2_Cardiac contractility modulation to enhance optimized medical therapy and improve cardiac remodeling in advanced heart failure: a case report.avi
Published 2025“…NT-proBNP levels also decreased from 6,553 pg/ml to within the normal range.…”
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17166
Supplementary file 1_Disproportionality analysis of taste disorders using the FDA adverse event reporting system and Japanese adverse drug event report databases.docx
Published 2025“…The hazard for clarithromycin remained constant throughout administration, while the hazards for the other drugs decreased over time. Logistic regression analysis confirmed significant associations between the drugs and taste disorders, even after adjusting for age and sex. …”
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17167
Table 3_MicroRNAs regulate alveolar macrophage homeostasis and its function in lung fibrosis.xlsx
Published 2025“…Our recent study found that the loss of miRNAs in embryonic progenitors significantly decreased the number of TR-AMs in late-stage embryos, indicating that miRNAs are necessary for TR-AM development. …”
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17168
Supplementary file 1_Dietary composition and fasting regimens differentially impact the gut microbiome and short-chain fatty acid profile in a Pakistani cohort.docx
Published 2025“…Ramadan fasting also led to a significant increase in SCFAs including C7, iC4, and iC6, accounting for variability in microbial composition and phylogeny, respectively. …”
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17169
Image 1_Multi level effects of Sanghuang Tongxie Formula on type 2 diabetes rats: a comprehensive analysis from intestinal bacteria to metabolome and transcriptome.tif
Published 2025“…</p>Results<p>SHTX treatment significantly altered the gut microbiota composition in T2DM rats, increasing the relative abundance of Bacteroidetes while decreasing that of Firmicutes, which was closely correlated with improved insulin sensitivity. …”
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17170
Table 1_Global, regional, and national trends in the incidence of pneumoconiosis among populations aged 20 and above from 1990 to 2021.xlsx
Published 2025“…Notably, the EAPC showed a statistically significant but very weak positive correlation with the 2021 Human Development Index (HDI) values.…”
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17171
Table 1_Inner engineering is associated with perceived improvements in relationship quality, interpersonal connections, and interpersonal compassion.docx
Published 2024“…Linear mixed-effects models were used to analyze the survey data, with p-values of < 0.05 considered statistically significant.</p>Results<p>From the baseline to the 6-week follow-up after the program, the participants reported experiencing more positive qualities (p < 0.001, ηp2 = 0.12) and fewer negative qualities (p = 0.001, ηp2 = 0.08) in their relationships, increased interpersonal mindfulness (p < 0.001, ηp2 = 0.30), decreased stress levels (p < 0.001, ηp2 = 0.27), enhanced compassion for others (p < 0.001, ηp2 = 0.17), and overall personal wellbeing (p < 0.001, ηp2 = 0.25).…”
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17172
Table 1_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.docx
Published 2025“…Crim1 encodes a type I transmembrane protein that is expressed at the cell membrane of lens epithelial and fiber cells at the stage of lens pit formation. Decreased Crim1 expression in the mouse reduced the number of lens epithelial cells and caused defective adhesion between lens epithelial cells and between the epithelial and fiber cells.…”
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17173
Table 1_A population-based study of social demographic factors, associated diseases, and herpes zoster ophthalmicus in Taiwan.docx
Published 2025“…</p>Results<p>Patients with systemic diseases (hypertension, diabetes, hyperlipidaemia, etc.) had significantly higher ORs for HZO development. Patients whose monthly income was >NT$ 30,000 and patients residing in southern Taiwan had increased odds of developing HZO; however, patients residing in northern Taiwan, metropolitans, or satellite cities, and being public servants (military, civil, teaching staff, etc.) had decreased odds of developing HZO.…”
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17174
Data Sheet 1_Unveiling nitrogen preferences in indica rice: a classification study of cultivars in South China.pdf
Published 2025“…Compared with the 100:0 treatment, the maximum root length, shoot length, root dry weight, shoot dry weight, and total dry weight in the 75:25 treatment significantly increased by 29.85%, 4.11%, 7.65%, 1.71% and 3.03% (p < 0.01), respectively; and the SPAD value in the 0:100 treatment significantly decreased by 4.22% (p < 0.01).…”
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17175
Table 1_Lyophyllum decastes-derived polysaccharides alleviate DSS-induced colitis in mice by suppressing inflammation, enhancing intestinal barrier integrity, and restoring gut mic...
Published 2025“…</p>Results and discussion<p>LDP treatment significantly reduced DAI scores and preserved colonic histological structure. …”
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17176
Table 2_Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea.docx
Published 2025“…</p>Results<p>Both the low-frequency electroacupuncture group and the high-frequency electroacupuncture group significantly reduced writhing scores, increased spleen index, decreased prostaglandin PGF2α and COX-2 levels, and increased prostaglandin PGE2 and β-EP levels to varying degrees.…”
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17177
DataSheet3_Screening of active components of melastoma dodecandrum lour. against diabetic osteoporosis using cell membrane chromatography-mass spectrometry.pdf
Published 2024“…Cell experiments further validated the activity of the characteristic component isovitexin.</p>Results<p>MD significantly improved cell viability in AGEs-damaged osteoblasts, enhanced ALP, SOD, CAT, and GPx activities, reduced MDA levels, increased OCN and RUNX2 protein expression, and decreased TNF-α mRNA and RAGE protein expression. …”
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17178
Table 1_The role of gut microbiota in modulating immune responses in chronic liver disease: a systematic review and meta-analysis.docx
Published 2025“…Interleukin-6 (IL-6) levels showed no significant change between the groups (SMD, -0.67; 95% CI [-1.5, 0.12) p = 0.09). …”
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17179
Image 1_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.tiff
Published 2025“…Crim1 encodes a type I transmembrane protein that is expressed at the cell membrane of lens epithelial and fiber cells at the stage of lens pit formation. Decreased Crim1 expression in the mouse reduced the number of lens epithelial cells and caused defective adhesion between lens epithelial cells and between the epithelial and fiber cells.…”
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17180
DataSheet1_Strict biennial lifecycle and anthropogenic interventions affect temporal genetic differentiation in the endangered endemic plant, Pedicularis hallaisanensis.docx
Published 2024“…Other cluster analyses also showed that a microhabitat under historical anthropogenic interventions contained lowered genetic diversity due to a decreased genetic distance between odd-year and even-year flowering cohorts (p < 0.05). …”