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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
challenges decrease » challenges case (Expand Search)
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18341
Table 1_Trends in cervical cancer incidence and mortality in the United States, 1975–2018: a population-based study.docx
Published 2025“…</p>Conclusion<p>For cervical cancer cases diagnosed in the United States from 1975 to 2018, the overall incidence and mortality rates decreased significantly. However, there was an increase in the incidence and mortality of advanced-stage squamous cell carcinoma. …”
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18342
Comparisons of separability and variance of evidence distributions when noise and variability are manipulated independently for the 4-layer CNN across the three experiments.
Published 2024“…On the other hand, separability of evidence distributions decreased significantly from the low to high variability condition and the variance of evidence distribution increased from the low to high variability conditions for all experiments.…”
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18343
Genomic DNA yield and integrity obtained from MDR-TB and DS-TB isolate cultures.
Published 2025“…A) DNA yields extracted from MGIT tubes over time; there was no change in MDR-TB DNA yield, but the DS-TB isolate yield decreased. B) DNA amounts extracted from 7H11 slopes over time; there was no change in MDR-TB DNA yields, but DS-TB isolate yields decreased. …”
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18344
Data Sheet 1_Dehydrozaluzanin C inhibits colon cancer cell proliferation, apoptosis and cycle arrest through peroxisome proliferator-activated receptor γ (PPARγ) activation.pdf
Published 2025“…In vivo, DC treatment significantly decreased the weight and volume of xenograft tumor tissues in mice and apoptosis-related protein levels. …”
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18345
Data Sheet 1_Continuous cropping of Patchouli alters soil physiochemical properties and rhizosphere microecology revealed by metagenomic sequencing.docx
Published 2025“…In addition, S-PPO enzyme activity increased significantly with the cropping years, but S-NAG increased in the first 2 years and decreased in the third cropping year. …”
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18346
Table 1_Continuous cropping of Patchouli alters soil physiochemical properties and rhizosphere microecology revealed by metagenomic sequencing.xlsx
Published 2025“…In addition, S-PPO enzyme activity increased significantly with the cropping years, but S-NAG increased in the first 2 years and decreased in the third cropping year. …”
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18347
Cardiovascular safety of Janus kinase inhibitors in inflammatory bowel disease: a systematic review and network meta-analysis
Published 2025“…</p> <p>Although a trend of increased cardiovascular risks was found considering dose, no significantly increased cardiovascular risk was associated with JAKinibs in IBD patients, and Deucravacitinib significantly decreased the risks of VTE and CVE.…”
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18348
Supplementary Material for: Dose-effect Relationship of Hyperbaric Oxygen Therapy in Rats with Amnestic Mild Cognitive Impairment
Published 2025“…Results:After hyperbaric oxygen treatment, compared with the aMCI group, the escape latency of each HBO subgroup was significantly shortened (p<0.001). The 2.0ATA subgroup (p=0.001), 2.2ATA subgroup (p=0.001)and 2.5ATA subgroup ( p=0.002) significantly increased the number of platform crossings.the levels of SOD were significantly increased in1.6ATA subgroup (p=0.019), 1.8ATA subgroup(p =0.003), 2.0ATA subgroup(p=0.010 ) and 2.2ATA group(p=0.016) and MDA contents were significantly decreased in the 1.6ATA subgroup(p=0.015), 1.8ATA subgroup(p =0.012), 2.0ATA subgroup(p=0.002), and 2.2ATA subgroups (p<0.001), and the levels of eNOS were significantly decreased in the 1.8ATA subgroup(p=0.007) and 2.0ATA subgroup (p=0.029),and the expression of nNOS were significantly decreased in the 1.8ATA subgroup (p=0.006),2.0ATA subgroup (p<0.001) and the 2.2ATA subgroup ( p< 0.001). …”
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18349
Data Sheet 1_Leaf hydraulic decline coordinates stomatal and photosynthetic limitations through anatomical adjustments under drought stress in cotton.docx
Published 2025“…By day 28 after drought stress, drought stress significantly impaired leaf hydraulics, as demonstrated by decreases in leaf hydraulic conductivity (K<sub>leaf</sub>) (9.81% under MD, 12.93% under SD) and leaf water potential (5.79% under MD, 17.54% under SD). …”
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18350
<b>Tracking incidence classification changes across disturbances at Konza Prairie LTER</b>
Published 2025“…Plants had the most populations classified as directed change (increasing=241/253, decreasing=95/101). The grazing press disturbance hypothesis was partially supported for plant taxa, which significantly differed by watershed treatments (Chi-square, p=3.182e-11). …”
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18351
Presentation 1_Efficacy of disitamab vedotin in non-small cell lung cancer with HER2 alterations: a multicenter, retrospective real-world study.pdf
Published 2024“…The most common adverse events included hand-foot syndrome (54.5%), asthenia (50.0%), decreased white blood cell count (45.5%), and liver impairment (45.5%). …”
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18352
Table1_CHF6297: a novel potent and selective p38 MAPK inhibitor with robust anti-inflammatory activity and suitable for inhaled pulmonary administration as dry powder.DOCX
Published 2024“…In a murine house dust mite (HDM) model of asthma exacerbated by influenza virus A (IAV) (H3N3), CHF6297 (0.1 mg/kg, i.n.) significantly decreased airway neutrophilia compared to vehicle-treated IAV/HDM-challenged mice. …”
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18353
Image1_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif
Published 2024“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”
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18354
Table1_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.docx
Published 2024“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”
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18355
Image3_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif
Published 2024“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”
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18356
Image4_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif
Published 2024“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”
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18357
Image2_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif
Published 2024“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”
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18358
Data Sheet 1_Dynamics of soil nutrients and biological activities along an infection chronosequence of pine wilt disease in subtropical Masson pine forests.docx
Published 2025“…The results revealed that soil non-capillary porosity, clay, microbial biomass carbon and microbial biomass nitrogen decreased significantly in 6 years forests. Available potassium consistently decreased with longer invasion periods, while soil polyphenol oxidase, leucine amino peptidase, and available phosphorous peaked in 6 years forests and then declined over time. …”
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18359
Exploratory investigation on conversion behaviors and coking tendency during coal-based asphaltene hydrogenation processes
Published 2024“…And moreover, with hydrogen pressure increases from 2MPa to 4MPa, oil yield increases from 65.28% to 71.16% while coke yield decreases significantly from 8.85% to 2.90%, which indicates that relatively increase hydrogen pressure can effectively stabilize the free radicals to produce oil and restrict the generation of coke at 470°C. …”
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18360
Data Sheet 1_Genetic variation in RYR1 is associated with heart failure progression and mortality in a diverse patient population.docx
Published 2025“…Based on eQTL data, these SNPs were associated with decreased RYR1 expression in vascular tissue. Two missense variants, in linkage disequilibrium with rs2915950 (rs2915952 and rs2071089) were significantly associated with decreased mortality risk (P = 0.03) and decreased risk of atrial fibrillation/flutter (OR: 0.66, 95% CI: 0.44–0.96; P = 0.03 and OR: 0.67, 95% CI: 0.45–0.98; P = 0.04, respectively). …”