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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
challenges decrease » challenges case (Expand Search)
linear decrease » linear increase (Expand Search)
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5841
Supplementary file 1_Cornuside mitigates acute lung injury through suppression of NLRP3 inflammasome-mediated pyroptosis and activation of the Keap1-Nrf2 antioxidant response.docx
Published 2025“…</p>Results<p>CNS significantly improved survival, reduced pulmonary edema, and alleviated lung inflammation and locomotor deficits in LPS-challenged mice. …”
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5842
Image 1_Cornuside mitigates acute lung injury through suppression of NLRP3 inflammasome-mediated pyroptosis and activation of the Keap1-Nrf2 antioxidant response.tif
Published 2025“…</p>Results<p>CNS significantly improved survival, reduced pulmonary edema, and alleviated lung inflammation and locomotor deficits in LPS-challenged mice. …”
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5843
Image 2_Cornuside mitigates acute lung injury through suppression of NLRP3 inflammasome-mediated pyroptosis and activation of the Keap1-Nrf2 antioxidant response.tif
Published 2025“…</p>Results<p>CNS significantly improved survival, reduced pulmonary edema, and alleviated lung inflammation and locomotor deficits in LPS-challenged mice. …”
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5844
Image 3_Cornuside mitigates acute lung injury through suppression of NLRP3 inflammasome-mediated pyroptosis and activation of the Keap1-Nrf2 antioxidant response.tif
Published 2025“…</p>Results<p>CNS significantly improved survival, reduced pulmonary edema, and alleviated lung inflammation and locomotor deficits in LPS-challenged mice. …”
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5845
Table 2_Determining the efficacy and safety of acupuncture for the treatment of menstrual migraine: an updated systematic review and meta-analysis.docx
Published 2025“…Compared with control interventions, acupuncture significantly reduced VAS scores, decreased the frequency and duration of migraine attacks, and improved response rates, as well as HIT-6 and MHI scores. …”
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5846
Presentation 1_Efficacy of disitamab vedotin in non-small cell lung cancer with HER2 alterations: a multicenter, retrospective real-world study.pdf
Published 2024“…Background<p>Non-small cell lung cancer (NSCLC) with human epidermal growth factor receptor 2 (HER2) alterations poses a substantial treatment challenge. Current HER2-targeted therapies offer limited efficacy. …”
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5847
Table1_CHF6297: a novel potent and selective p38 MAPK inhibitor with robust anti-inflammatory activity and suitable for inhaled pulmonary administration as dry powder.DOCX
Published 2024“…In a murine house dust mite (HDM) model of asthma exacerbated by influenza virus A (IAV) (H3N3), CHF6297 (0.1 mg/kg, i.n.) significantly decreased airway neutrophilia compared to vehicle-treated IAV/HDM-challenged mice. …”
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5848
Image1_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif
Published 2024“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”
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5849
Table1_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.docx
Published 2024“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”
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5850
Image3_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif
Published 2024“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”
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5851
Image4_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif
Published 2024“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”
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5852
Image2_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif
Published 2024“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”
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5853
OVD-induced transient OHT in mice leads to RGC loss and astrocyte reactivity.
Published 2025“…<p>(A) OVD injections led to IOP increase, with values presented as means ± SD. IOP decreased 6 hours post-injection and by day 1 had returned to near baseline levels. …”
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5854
Heart looping variations in <i>Notch3</i> and <i>Nodal</i> compound mutants.
Published 2025“…</i> Filled and empty arrowheads point to curved and straight outflow tract, respectively. Means and standard deviations are shown. L, Left; LV, left ventricle; n.s., non-significant; R, Right; RV, right ventricle. …”
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5855
Table 1_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx
Published 2025“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”
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5856
Table 4_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx
Published 2025“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”
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5857
Image 1_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.tif
Published 2025“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”
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5858
Table 3_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx
Published 2025“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”
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5859
Table 2_Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.xlsx
Published 2025“…Estimates are presented as means with 95% uncertainty intervals (UIs).</p>Results<p>In 2021, the global age-standardized prevalence rate of HHD was 148.32 (95% UI: 117.32, 186.28) per 100,000 population. …”
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5860
Broader frequency tuning in auditory cortex of <i>Fmr1</i> KO rats despite unaltered subcortical tuning properties.
Published 2025“…Boxplots dots represent individual multiunit clusters. All other values are means ± SEM. **<i>p</i> < 0.01, ***<i>p</i> < 0.0001, ns = not significant. …”