يعرض 3,021 - 3,040 نتائج من 3,191 نتيجة بحث عن '(( significant challenges decrease ) OR ( significantly ((nn decrease) OR (linear decrease)) ))', وقت الاستعلام: 0.54s تنقيح النتائج
  1. 3021

    Image 1_Multi-omics analysis reveals indicator features of microbe-host interactions during Candida albicans colonization and subsequent infection.tif حسب Huan Zhang (220065)

    منشور في 2024
    "…</p>Importance<p>Candida albicans invasive infections pose a significant challenge to contemporary medicine, with mortality rates from such fungal infections remaining high despite antifungal treatment. …"
  2. 3022

    Data Sheet 3_CD44 knockdown alters miRNA expression and their target genes in colon cancer.pdf حسب Diana Maltseva (11678641)

    منشور في 2025
    "…Introduction<p>Metastasis formation poses a significant challenge to oncologists, as it severely limits the survival of colorectal cancer (CRC) patients. …"
  3. 3023

    Data Sheet 1_Prognostic model construction and immune microenvironment analysis of pyroptosis-related genes in hepatocellular carcinoma based on single-cell RNA sequencing.zip حسب Haoming Shen (3816988)

    منشور في 2025
    "…Background<p>Hepatocellular carcinoma (HCC) prognosis continues to be challenging due to tumor heterogeneity and dynamic immunosuppressive microenvironments. …"
  4. 3024

    Image 2_A comprehensive study of hip dislocation: global health burden from 1990 to 2021 and its predictions to 2030.pdf حسب Xu Zheng (296676)

    منشور في 2025
    "…</p>Conclusion<p>The disease burden of hip dislocation remains a significant public health challenge. Data-driven analysis is pivotal for guiding clinical practice, shaping public health policies, and ensuring optimal allocation of healthcare resources. …"
  5. 3025

    Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario حسب Karoliny Nune Santos (21752603)

    منشور في 2025
    "…<p>Preeclampsia (PE) is characterized by systemic endothelial dysfunction and remains a significant clinical challenge. Activation of NLRP3 inflammasome, reactive oxygen species (ROS) production, and pyroptosis and autophagy are important mechanisms in this condition. …"
  6. 3026

    Image 1_A comprehensive study of hip dislocation: global health burden from 1990 to 2021 and its predictions to 2030.tif حسب Xu Zheng (296676)

    منشور في 2025
    "…</p>Conclusion<p>The disease burden of hip dislocation remains a significant public health challenge. Data-driven analysis is pivotal for guiding clinical practice, shaping public health policies, and ensuring optimal allocation of healthcare resources. …"
  7. 3027

    Table 2_A comprehensive study of hip dislocation: global health burden from 1990 to 2021 and its predictions to 2030.docx حسب Xu Zheng (296676)

    منشور في 2025
    "…</p>Conclusion<p>The disease burden of hip dislocation remains a significant public health challenge. Data-driven analysis is pivotal for guiding clinical practice, shaping public health policies, and ensuring optimal allocation of healthcare resources. …"
  8. 3028

    Table 1_A comprehensive study of hip dislocation: global health burden from 1990 to 2021 and its predictions to 2030.docx حسب Xu Zheng (296676)

    منشور في 2025
    "…</p>Conclusion<p>The disease burden of hip dislocation remains a significant public health challenge. Data-driven analysis is pivotal for guiding clinical practice, shaping public health policies, and ensuring optimal allocation of healthcare resources. …"
  9. 3029

    AjMLKL is involved in 10<sup>8</sup> CFU/mL AJ01 induced lytic coelomocyte death independent on its phosphorylation. حسب Kaiyu Chen (11691918)

    منشور في 2025
    "…Treatment of sea cucumber coelomocytes with 100 μM GW806724X for 3 h and then challenged by 10<sup>8</sup> CFU/mL AJ01. Coelomocyte viability was significantly increased (L), and coelomocytes plasma membrane disruption (M) and the percentage of Annexin V+/PI+ coelomocytes significantly decreased (N). …"
  10. 3030

    Image 1_Analysis and contrast of psoriasis disease burden trends in China and globally from 1990 to 2021.tiff حسب Keyi Yu (8958845)

    منشور في 2025
    "…</p>Conclusion<p>Psoriasis poses a substantial public health challenge in China due to the country’s large and increasingly aging populace. …"
  11. 3031

    Video 2_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

    منشور في 2025
    "…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …"
  12. 3032

    Image1_Oleic acid attenuates asthma pathogenesis via Th1/Th2 immune cell modulation, TLR3/4-NF-κB-related inflammation suppression, and intrinsic apoptotic pathway induction.tif حسب Soon-Young Lee (4721136)

    منشور في 2024
    "…The incidence is expected to increase as the average life expectancy increases, highlighting asthma as a significant health challenge in an aging society. The etiology of asthma is linked to an imbalance of Th1 and Th2 cells, respiratory inflammation, and pulmonary cell proliferation. …"
  13. 3033

    Video 5_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

    منشور في 2025
    "…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …"
  14. 3034

    Data Sheet 1_Association of oxidative balance score with all-cause and cardiovascular mortality among patients with cardio-renal-metabolic disease.docx حسب Yucui Lin (21598376)

    منشور في 2025
    "…Moreover, Higher OBS quartiles were linked to a decreased risk of cardiovascular mortality, while no significant reduction was observed in the lower quartiles [model 3: Q2, Q3, Q4: aHR (95CI%) = 0.96(0.77–1.19), 0.78 (0.63–0.97), 0.70 (0.53–0.93), respectively; P for trend = 0.003]. …"
  15. 3035

    Video 1_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

    منشور في 2025
    "…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …"
  16. 3036

    Image 2_Analysis and contrast of psoriasis disease burden trends in China and globally from 1990 to 2021.tif حسب Keyi Yu (8958845)

    منشور في 2025
    "…</p>Conclusion<p>Psoriasis poses a substantial public health challenge in China due to the country’s large and increasingly aging populace. …"
  17. 3037

    Data Sheet 1_The multivalent passive immune-protective vaccines of egg yolk immunoglobulin Y derived from live or inactivated Pseudomonas anguilliseptica against aquaculture pathog... حسب Pan Cui (5726669)

    منشور في 2025
    "…Furthermore, the structures of the kidney, spleen, and intestinal tissues were intact, and the expression of p53 and γH2A.X decreased in the kidney.</p>Conclusion<p>L-PA-IgY and I-PA-IgY can resist multiple bacterial infections and have immunoprotective effects with no significant differences. …"
  18. 3038

    Video 6_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

    منشور في 2025
    "…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …"
  19. 3039

    Data Sheet 2_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.docx حسب Lina Ouologuem (22489549)

    منشور في 2025
    "…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …"
  20. 3040

    Video 4_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 حسب Lina Ouologuem (22489549)

    منشور في 2025
    "…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …"