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significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
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nn decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
significant challenges » significant challenge (Expand Search), significant changes (Expand Search)
challenges decrease » challenges case (Expand Search)
linear decrease » linear increase (Expand Search)
nn decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
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3041
Data Sheet 1_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.docx
Published 2025“…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …”
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3042
Data Sheet 1_IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection.pdf
Published 2025“…Introduction<p>Malaria remains a significant public health challenge in Brazil, where Plasmodium vivax (P. vivax) is the predominant species. …”
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3043
Video 3_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4
Published 2025“…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …”
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3044
Video 7_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4
Published 2025“…Introduction<p>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. …”
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3045
DataSheet1_Effects of mesenchymal stromal cells and human recombinant Nerve Growth Factor delivered by bioengineered human corneal lenticule on an innovative model of diabetic reti...
Published 2024“…In the last years, mesenchymal stromal cells (MSCs) and neurotrophins like Nerve Growth Factor (NGF), have garnered significant attention as innovative therapeutic approaches targeting DR-associated neurodegeneration. …”
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3046
Image 1_Regulation effect of seed priming on sowing rate of direct seeding of rice under salt stress.pdf
Published 2025“…However, the global intensification of soil salinization presents a significant challenge to food security. Increasing sowing rates is a common practice to enhance germination under salt stress, although it leads to higher seed costs. …”
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3047
Table 1_CD9 regulates proliferation, invasion, migration and radioresistance of esophageal squamous cell carcinoma by activating AKT/GSK3β signaling pathway.docx
Published 2025“…Background<p>Radioresistance poses a major therapeutic challenge in ESCC, significantly impacting patient prognosis. …”
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3048
Table 1_Regulation effect of seed priming on sowing rate of direct seeding of rice under salt stress.pdf
Published 2025“…However, the global intensification of soil salinization presents a significant challenge to food security. Increasing sowing rates is a common practice to enhance germination under salt stress, although it leads to higher seed costs. …”
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3049
Data Sheet 1_The efficacy and safety of panax quinquefolius saponin for heart failure: a systematic review and meta-analysis.pdf
Published 2025“…Background<p>Heart failure (HF) is a global health concern, affecting millions of individuals worldwide and leading to significant morbidity and mortality. Despite advances in conventional therapeutic strategies, the prognosis for HF patients remains challenging, and there is a constant search for novel therapeutic options. …”
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3050
Supplemental_Figure_of_Imeglimin_ameliorate_SA-AKI
Published 2025“…Serum ALT levels were not significantly different before and after E. coli challenge between the Ime and Veh groups. …”
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3051
Table 1_Organic and inorganic fertilizers modulate the response of the soil microbiome to salinity stress.docx
Published 2025“…Conversely, the application of NPK fertilizer reduced bacterial richness, alpha diversity and soil multifunctionality by 14.52, 5.83, and 12.34%, respectively, further disrupting the microbial community and making resilience to salinity stress more challenging. Furthermore, NPK fertilization increased bacterial network complexity but decreased its stability. …”
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3052
Image 1_Evaluating two live-attenuated vaccines against Salmonella enterica serovar Reading in turkeys: reduced tissue colonization and cecal tonsil transcriptome responses.pdf
Published 2024“…Salmonella dissemination to the spleen was significantly reduced by both vaccines. Gene expression of intestinal transporters (such as SCNN1B and SLC10A2) and tight junction proteins was significantly decreased in the turkey cecal tonsil transcriptome at 2 DPI with S. …”
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3053
Table 2_Evaluating two live-attenuated vaccines against Salmonella enterica serovar Reading in turkeys: reduced tissue colonization and cecal tonsil transcriptome responses.xlsx
Published 2024“…Salmonella dissemination to the spleen was significantly reduced by both vaccines. Gene expression of intestinal transporters (such as SCNN1B and SLC10A2) and tight junction proteins was significantly decreased in the turkey cecal tonsil transcriptome at 2 DPI with S. …”
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3054
Table 1_Evaluating two live-attenuated vaccines against Salmonella enterica serovar Reading in turkeys: reduced tissue colonization and cecal tonsil transcriptome responses.xlsx
Published 2024“…Salmonella dissemination to the spleen was significantly reduced by both vaccines. Gene expression of intestinal transporters (such as SCNN1B and SLC10A2) and tight junction proteins was significantly decreased in the turkey cecal tonsil transcriptome at 2 DPI with S. …”
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3055
Image 3_Evaluating two live-attenuated vaccines against Salmonella enterica serovar Reading in turkeys: reduced tissue colonization and cecal tonsil transcriptome responses.pdf
Published 2024“…Salmonella dissemination to the spleen was significantly reduced by both vaccines. Gene expression of intestinal transporters (such as SCNN1B and SLC10A2) and tight junction proteins was significantly decreased in the turkey cecal tonsil transcriptome at 2 DPI with S. …”
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3056
Image 2_Evaluating two live-attenuated vaccines against Salmonella enterica serovar Reading in turkeys: reduced tissue colonization and cecal tonsil transcriptome responses.pdf
Published 2024“…Salmonella dissemination to the spleen was significantly reduced by both vaccines. Gene expression of intestinal transporters (such as SCNN1B and SLC10A2) and tight junction proteins was significantly decreased in the turkey cecal tonsil transcriptome at 2 DPI with S. …”
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3057
DataSheet1_Effects of fertilization on litter decomposition dynamics and nutrient release in orchard systems.docx
Published 2024“…Although adding nutrients decreased soil enzyme activity later in the decomposition process, no significant correlation was detected between enzyme activity and the remaining mass. …”
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3058
Data Sheet 1_Dietary supplementation with polypeptin and bioture improves growth, feed utilization, antioxidant capacity, and disease resistance in juvenile hybrid grouper (Epineph...
Published 2025“…Fish were fed experimental diets for 56 days, followed by a 144 h challenge with Vibrio harveyi. The results showed that co-supplementation significantly improved multiple performance indicators, exhibiting notable synergistic effects: final body weight, weight gain, and specific growth rate increased, while feed conversion ratio and hepatosomatic index decreased. …”
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3059
Image 1_Vitamin K protects against lipopolysaccharide-induced intestinal inflammation in piglets by inhibiting the MAPK and PI3K-AKT pathways.pdf
Published 2025“…</p>Results<p>Morphological analysis revealed that VK significantly restored the decreased villus height and ratio of villus height to crypt depth induced by LPS. …”
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3060
Data Sheet 2_Predicting mortality in heart failure: BUN/creatinine ratio in MIMIC-III.docx
Published 2025“…</p>Conclusions<p>Admission BCR values are non-linearly associated with mortality in heart failure patients, suggesting its utility as a prognostic tool in critical care.…”