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significant change » significant changes (Expand Search), significant challenge (Expand Search), significant challenges (Expand Search)
change decrease » change increases (Expand Search), change degree (Expand Search)
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19341
Long-Term Effects of Adalimumab in Juvenile Idiopathic Arthritis-Associated Uveitis: 3- and 6-Year Results of the ADJUVITE Trial
Published 2025“…The mean dose of methotrexate decreased significantly from 11.3 ± 4.4 mg/week at the end of the trial to 5.2 ± 6.2 mg/week at the last follow-up (<i>p</i> = 0.002). …”
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19342
DataSheet1_Clinical associations of complement-activating collectins, collectin-10, collectin-11 and mannose-binding lectin in preterm neonates.pdf
Published 2024“…An important finding was the decreased concentrations of CL-10, CL-11 and MBL in respiratory distress syndrome (RDS). …”
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19343
Data Sheet 1_Polydatin combined with hawthorn flavonoids alleviate high fat diet induced atherosclerosis by remodeling the gut microbiota and glycolipid metabolism.pdf
Published 2025“…</p>Results<p>Polydatin combined with hawthorn flavonoids administration significantly reduced lipid and inflammatory cytokine levels, meanwhile, the atherosclerotic lesions in a high-fat diet-induced ApoE<sup>−/−</sup> mice were significantly decreased. …”
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19344
<b>Nonlinear and Sex-Specific Associations of Vitamin D Metabolites with Inflammatory Blood Markers in 455,000 Adults</b>
Published 2025“…Neutrophil counts were lowest at 25(OH)D levels of ~40–60 nmol/L and increased significantly at both lower and higher extremes (p < 0.001). …”
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19345
<b>Nonlinear and Sex-Specific Associations of Vitamin D Metabolites with Inflammatory Blood Markers in 455,000 Adults</b>Item
Published 2025“…Neutrophil counts were lowest at 25(OH)D levels of ~40–60 nmol/L and increased significantly at both lower and higher extremes (p < 0.001). …”
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19346
Supplementary data.xlsx
Published 2025“…However, recent studies have indicated that the telomere length of somatic cells can be drastically decreased in the offspring receiving in vitrofertilization (IVF) therapy, however, the underlying molecular mechanism remains unknown. …”
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19347
TNC promotes bone regeneration via inflammatory macrophage
Published 2024“…Transplantation of macrophages derived from injured periosteum is able to rescue the decreased skeletal stem cells and impaired bone regeneration caused by TNC deficiency. …”
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19348
Source data.xlsx
Published 2025“…This limitation restricts electrode thickness, decreases power density, and shortens battery lifetime. …”
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19349
Table 1_Gut microbiota alterations and systemic inflammation in community-acquired pneumonia: a prospective gut-lung axis study.docx
Published 2025“…The abundance of short-chain fatty acid-producing genera in CAP patients decreased significantly, such as Blautia and Agathobacter. …”
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19350
Additional file 2 of Single-cell profiling reveals periosteal signatures of impaired periosteal cells proliferation in a drill-hole model of type 2 diabetes
Published 2025“…Impaired callus remodeling and decreased osteogenic activity in db/db mice during fracture healing. …”
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19351
Glycogen synthase kinase 3 promotes the proliferation of porcine epidemic diarrhea virus by phosphorylating the nucleocapsid protein
Published 2025“…The phosphorylation level significantly decreased after mutation of threonine (Thr) to serine (Ser). …”
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19352
Image 2_ATG16L1 promotes cell migration and invasion in high glucose–induced retinal capillary endothelial cells.tif
Published 2025“…The migration ability and invasion rate of RCECs were significantly higher in the HG group than in the NG group but decreased markedly after transfection with ATG16L1 siRNA, compared with those in the control group (p < 0.01).…”
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19353
Image 1_ATG16L1 promotes cell migration and invasion in high glucose–induced retinal capillary endothelial cells.tif
Published 2025“…The migration ability and invasion rate of RCECs were significantly higher in the HG group than in the NG group but decreased markedly after transfection with ATG16L1 siRNA, compared with those in the control group (p < 0.01).…”
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19354
Data Sheet 1_Virus-like particles containing the extracellular domain of G protein in combination with a CTL peptide of M2 elicit protection against respiratory syncytial virus inf...
Published 2025“…Compared with the UV-RSV control group, both G<sub>ECD</sub>/M2<sub>82-90</sub>-VLPs and G<sub>ECD</sub>-VLPs groups exhibited significantly increased Th1-type cytokine levels and decreased Th2-type cytokine concentrations (P<0.05, P<0.001). …”
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19355
<b>Antiretroviral therapy </b><b>does not correct the dysregulations of plasma virome and cytokines induced by HIV-1</b>
Published 2024“…These results indicate that ART does not significantly correct the virome and cytokine dysregulations associated with HIV-1 infection.…”
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19356
<b>Antiretroviral therapy</b><b> does not correct the dysregulations of plasma virome and cytokines induced by HIV-1</b>
Published 2024“…These results indicate that ART does not significantly correct the virome and cytokine dysregulations associated with HIV-1 infection.…”
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19357
Data Sheet 1_Lethal and sublethal effects of chemical and bio-insecticides on Spodoptera frugiperda adults: new perspectives for “attract-and-kill” control strategies.pdf
Published 2025“…Sublethal exposure to chlorantraniliprole significantly reduced larval and pupal development durations, decreased pupal weights, and shortened adult longevity in the offspring, without significantly affecting larval mortality, pupation rate, or emergence rate. …”
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19358
Source data.zip
Published 2025“…In vivo, melatonin significantly increased MT1R (melatonin receptor 1A) expression in BPA-treated mouse testicular cells and the content of catalase, superoxide dismutase 2, and glutathione, while decreasing the level of malondialdehyde. …”
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19359
Data Sheet 14_Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment.zip
Published 2025“…Objective<p>Previous research has demonstrated that the hypoxic environment at high altitudes significantly alters the pharmacokinetics of many drugs, reducing their efficacy and increasing adverse effects. …”
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19360
Data Sheet 4_Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment.zip
Published 2025“…Objective<p>Previous research has demonstrated that the hypoxic environment at high altitudes significantly alters the pharmacokinetics of many drugs, reducing their efficacy and increasing adverse effects. …”