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significant changes » significant challenge (Expand Search)
changes decrease » larger decrease (Expand Search), change increases (Expand Search)
largest decrease » larger decrease (Expand Search), marked decrease (Expand Search)
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5241
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5242
Table 1_Research on the effect of Rosa roxburghii root in alleviating spleen and stomach damp–heat gastric ulcer by regulating the imbalance of oral–gut axis microbiota.xlsx
Published 2025“…A 16S ribosomal RNA (rRNA) sequencing was conducted on samples of tongue coating and intestinal contents to analyze the microbial composition and changes.</p>Results and discussion<p>Compared to the control (CON) group, the gastric ulcer (GU) group exhibited significant pathological alterations in the gastric mucosa. …”
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5243
Data Sheet 1_The effects of acupoint catgut embedding therapy on anthropometric parameters and endocrine function in obese women: a systematic review and meta-analysis.pdf
Published 2025“…Hormonal changes included decreased LH and FSH and increased E2.…”
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5244
Supplementary Material for: Status of inpatients with pediatric epilepsy in children’s hospitals in China (2016–2021)
Published 2024“…The root-mean-square-error between the Inter-Provincial Visits Indexes decreased from 1.70 to 0.90, decreasing significantly (R2=0.8306). …”
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5245
Supplementary file 1_Persistent burden and health inequalities of disease in women of childbearing age attributable to Intimate Partner Violence, 1990–2021.docx
Published 2025“…Aims<p>Intimate Partner Violence (IPV) presents a significant global public health issue, particularly affecting women of childbearing age (WBCA). …”
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5246
Structural analysis of wild type and mutated variants of CXCR4.
Published 2024“…The changes in H-bond in the 3D structure of the CXCR4 protein likely have a significant impact on the structure functions of the protein.…”
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5247
Supplementary Material for: Impact of Abemaciclib-induced Serum Creatinine Elevation on Dose Adjustment of Concomitant Medications
Published 2025“…Results: Of 221 patients included in this study, 30.8% had grade ≥2 Scr elevation at 1 month post-ABE initiation, increasing to 56.6% after 2 years. CCr significantly decreased after ABE initiation compared with that at baseline (median [interquartile range]: 44.5 [34.7–55.7] mL/min vs. 61.6 [49.3–81.1] mL/min, P < 0.01). …”
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5248
Urbanization and climate jointly shape the composition of plant life forms
Published 2024“…<p dir="ltr">Urbanization and climate change are rapidly altering large-scale plant distributions and local community compositions, with profound impacts on ecosystem functions and services. …”
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5249
Effectiveness of Interventions to Reduce Sedentary Behaviour in People with Chronic Obstructive Pulmonary Disease: A Systematic Review of Randomised Controlled Trials
Published 2025“…Another study using a behaviour change intervention reduced sedentary behaviour by 64 minutes/day compared to baseline, significantly more than the control group (<i>p</i> = 0.018). …”
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5250
Table 1_Belimumab-driven reductions in retinal microvascular density assessed by optical coherence tomography angiography: insights from systemic lupus erythematosus patients.docx
Published 2025“…</p>Result<p>LN patients showed significantly reduced macular vascular density compared with non-LN patients. …”
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5251
Table 2_Integrative physiological, biochemical, and metabolomic analyses reveal complex drought and zinc stress tolerance in a novel Miscanthus hybrid.xlsx
Published 2025“…Fatty acid derivatives, nitrogen-containing compounds, hormone/signal-related compounds (jasmonate), and secondary metabolites (phenylpropanoids, N-containing compounds, and terpenes) showed significant (p < 0.05) abundance changes in response to D, Zn, and its combination D + Zn stress. …”
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5252
Data Sheet 1_Interaction between nasal epithelial cells and Tregs in allergic rhinitis responses to allergen via CCL1/CCR8.pdf
Published 2025“…In the AR + Derp1 group, TSLP was higher, and CCL1 protein levels were decreased. There were no significant differences in IL-25, TGF-β and IL-10. …”
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5253
Data Sheet 7_Global, regional, and national burdens of pancreatitis in children and adolescents aged 0–24 years from 1992 to 2021: a trend analysis based on the global burden of di...
Published 2025“…Background<p>The younger onset of pancreatitis presents a significant public health challenge. This study aims to analyze the global burden of pancreatitis in younger populations based on the Global Burden of Disease 2021.…”
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5254
Table 7_Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure.csv
Published 2025“…</p>Results<p>Myocardial energy metabolism in HF rats was disordered, characterized by reduced fatty acid oxidation, enhanced anaerobic glycolysis of glucose, mitochondrial damage, and decreased ATP content; The gut microbiota of HF rats was imbalanced, with a reduction in beneficial bacteria, an increase in conditional pathogenic bacteria, and impaired intestinal barrier function; Both Shenfu Injection and trimetazidine improved myocardial energy metabolism and cardiac function, but Shenfu Injection was more significant in regulating gut microbiota and improving intestinal health; The production of SCFAs from the gut microbiota of HF rats increased, which may be closely related to myocardial energy metabolism; SCFAs-producing bacteria Akkermansia and Blautia played a key role in the development of HF, and their abundance was positively correlated with SCFAs content.…”
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5255
Table 1_Exploring the antibacterial and anti-biofilm properties of Diacerein against methicillin-resistant Staphylococcus aureus.docx
Published 2025“…Background<p>Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant clinical challenge due to its multidrug resistance. …”
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5256
DataSheet1_Pressure-tolerant survival mechanism of Schizophyllum commune 20R-7-F01 isolated from deep sediments 2 kilometers below the seafloor.csv
Published 2024“…By assessing the cell viability, biomass, and cell wall thickness changes of strain 20-7-1 under different HHP conditions, we observed that, compared to 0.1 MPa, strain 20-7-1 exhibited slower growth rates and decreased cell viability at 15 MPa and 35 MPa, yet demonstrated significant pressure tolerance. …”
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5257
Image 2_Biometric parameters and choroidal microstructure in Chinese children with unilateral anisometropia.pdf
Published 2025“…The CVI decreases as hyperopia progresses to emmetropia and then to myopia, indicating that choroidal vascularity changes during refractive development.…”
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5258
Data Sheet 2_Assessing the evolution of infectious disease preparedness among a province with poor economy in China in the wake of COVID-19.docx
Published 2025“…Introduction<p>To identify the factors influencing changes in knowledge and experience of infectious disease prevention and control among physicians in Guangxis grassroots hospitals before and after the COVID-19 pandemic, thereby offering insights to enhance emergency response capabilities, disease prevention and control proficiency, and the overall effectiveness of grassroots medical institutions during epidemics.…”
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5259
Image 4_Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response.tif
Published 2025“…Treatment with these inhibitors also impacts neutrophil redox status, migration, and apoptosis without significantly changing overall bioenergetics.</p>Conclusions<p>Together, these results demonstrate that mitochondrial metabolism is dynamically remodeled and plays a significant role in neutrophils. …”
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5260
Data Sheet 2_Red mite (Panonychus citri) attack amplifies citrus rootstock-driven responses in physiological and biochemical traits, VOC emission, and expression of defence-related...
Published 2025“…<p>Citriculture faces significant constraints in expanding into new environments and agroecological zones. …”