يعرض 6,141 - 6,160 نتائج من 6,756 نتيجة بحث عن '(( significant changes decrease ) OR ( significant ((changes decrease) OR (largest decrease)) ))', وقت الاستعلام: 0.65s تنقيح النتائج
  1. 6141
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  6. 6146

    The impact of anesthesia and positioning on cerebral blood flow and pressure in patients undergoing laparoscopic surgery: an randomised observational study حسب alon lord (20342469)

    منشور في 2024
    "…In the REV group, CCA flow decreased after the Reverse Trendelenburg position (P=0.0213). …"
  7. 6147

    Table 1_Inflammatory markers CRP and WBC as predictors of liver function impairment in multiple injury trauma patients: a repeated measures analysis.docx حسب Gang Wang (36685)

    منشور في 2025
    "…</p>Conclusion<p>CRP and white blood cell count significantly correlate with liver function changes in multiple injury patients, with marked gender-specific differences in these associations. …"
  8. 6148

    Table 1_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.docx حسب Jikai He (11888466)

    منشور في 2025
    "…</p>Methods<p>(1) Fecal samples from CRC patients (n=26) and healthy controls (n=20) were collected for metagenomic sequencing and untargeted metabolomics analysis; (2) The ability of B.o to produce NMS from orange fiber was validated in vitro; (3) A CRC mouse model was established using azoxymethane (AOM)/dextran sulfate sodium (DSS) induction, followed by evaluation of body weight, rectal bleeding, colorectal length, tumor number, and intestinal barrier function; (4) Network pharmacology, molecular docking, and western blot analysis were combined to verify the mechanism of action; (5) 16S rRNA sequencing was performed to analyze gut microbiota changes.</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…"
  9. 6149

    DataSheet1_Global burden of chronic kidney disease in adolescents and young adults, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.docx حسب Ping Sun (59933)

    منشور في 2024
    "…However, the global age-specific death rate significantly decreased from 2.96 (2.76, 3.15) to 2.86 (2.61, 3.11), and the age-specific DALY rate remained stable. …"
  10. 6150

    Table 2_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.xlsx حسب Jikai He (11888466)

    منشور في 2025
    "…</p>Methods<p>(1) Fecal samples from CRC patients (n=26) and healthy controls (n=20) were collected for metagenomic sequencing and untargeted metabolomics analysis; (2) The ability of B.o to produce NMS from orange fiber was validated in vitro; (3) A CRC mouse model was established using azoxymethane (AOM)/dextran sulfate sodium (DSS) induction, followed by evaluation of body weight, rectal bleeding, colorectal length, tumor number, and intestinal barrier function; (4) Network pharmacology, molecular docking, and western blot analysis were combined to verify the mechanism of action; (5) 16S rRNA sequencing was performed to analyze gut microbiota changes.</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…"
  11. 6151

    Table 2_Modified maxillomandibular advancement for Eastern Asian patients with moderate or severe OSA: an anatomic and aerodynamic assessment of the upper airway.xlsx حسب Kan Li (490394)

    منشور في 2025
    "…The apnea–hypopnea index (36.05 ± 17.68 vs. 5.72 ± 4.76, p < 0.001) and the ESS (13.23 ± 8.9 vs. 6.23 ± 6.81 events/h, p < 0.05) decreased significantly, while the lowest oxygen saturation (76.54 ± 10.26% vs. 84.77 ± 6.02%, p < 0.05) improved greatly. …"
  12. 6152

    Table 1_Modified maxillomandibular advancement for Eastern Asian patients with moderate or severe OSA: an anatomic and aerodynamic assessment of the upper airway.xlsx حسب Kan Li (490394)

    منشور في 2025
    "…The apnea–hypopnea index (36.05 ± 17.68 vs. 5.72 ± 4.76, p < 0.001) and the ESS (13.23 ± 8.9 vs. 6.23 ± 6.81 events/h, p < 0.05) decreased significantly, while the lowest oxygen saturation (76.54 ± 10.26% vs. 84.77 ± 6.02%, p < 0.05) improved greatly. …"
  13. 6153

    Data Sheet 1_The CENPN/STAT3/USP37 signaling axis promotes invasion, migration and metastasis in nasopharyngeal carcinoma.docx حسب Yu-Fei Wang (322119)

    منشور في 2025
    "…</p>Results<p>The invasion and migration capacities of nasopharyngeal carcinoma cells decreased significantly after CENPN knockdown, whereas the overexpression of CENPN significantly promoted the invasion and metastasis abilities of nasopharyngeal carcinoma cells. …"
  14. 6154

    Data Sheet 1_Global, regional, and national burden of fracture of vertebral column, 1990–2021: analysis of data from the global burden of disease study 2021.docx حسب Yanni Lan (9092615)

    منشور في 2025
    "…Background<p>Fractures of the vertebral column, encompassing various spinal injuries, represent a significant public health burden worldwide. These injuries can lead to long-term disability, reduced quality of life, and substantial healthcare costs.…"
  15. 6155

    Supplementary Material for: High-sensitivity Troponin I Measurement in a Large Contemporary Cohort: Implications for Clinical Care حسب Esau D. (20563829)

    منشور في 2025
    "…Laboratory data, blood pressure, and anthropomorphic measures were extracted from the electronic medical record Results: Remeasurement of hsTnI did not change risk category in 92.7% of cases. Male sex, higher HDL-C, higher Hgb A1c, decreasing eGFR, and increasing systolic blood pressure were significant predictors of increased hsTnI. …"
  16. 6156

    Table 1_Rainfall distribution variability controls surface but not belowground litter decomposition in a semi-arid shrubland.docx حسب Yulin Li (36434)

    منشور في 2025
    "…</p>Results<p>Decomposition of belowground litter was consistently higher than that of surface litter over the entire field-incubation process. Mass loss significantly decreased in surface litter but not in belowground litter due to the lower frequency and larger amount of precipitation compared to the control treatment. …"
  17. 6157

    Table 1_Effects of neutral detergent fiber levels on apparent nutrient digestibility and intestinal microbiota composition and function in forest musk deer.docx حسب Qindan Dai (11056236)

    منشور في 2025
    "…At the genus level (the relative abundance > 1%), the three groups did not change (p > 0.05) significantly. In the KEGG function analysis, differentially expressed genes were primarily enriched in pathways related to organismal systems and human diseases. …"
  18. 6158

    Data Sheet 1_Use of the Temperament and Character Inventory to describe the effectiveness of Gestalt therapy.docx حسب Benjamin Calvet (11671588)

    منشور في 2025
    "…</p>Results<p>Statistically significant differences between the initial and final mean scores were observed for anxiety (t = 16.46; p < 0.0001), depression (t = 11.24; p < 0.0001), and harm avoidance (t = 8.82; p < 0.0001), and global psychological distress assessed by VAS (t = 18.7; p < 0.0001) (all showing decreased scores). …"
  19. 6159

    Source Apportionment of Atmospheric Iron in Northern China Based on Three-Year Continuous Measurements حسب Tianle Zhang (21796679)

    منشور في 2025
    "…Although PM<sub>2.5</sub> concentrations decreased significantly, the Fe component of PM<sub>2.5</sub> did not show a significant decline. …"
  20. 6160

    Data_Sheet_1_Effect of synbiotic supplementation on obesity and gut microbiota in obese adults: a double-blind randomized controlled trial.docx حسب Xiaokang Niu (13839428)

    منشور في 2024
    "…</p>Results<p>Synbiotics supplementation significantly decreased body fat percentage, waist, and serum low-density lipoprotein cholesterol (LDL-C), increased peptide YY, cholecystokinin, oxyntomodulin, GSH (glutathione peroxidase) in individuals with obesity. …"