بدائل البحث:
significant changes » significant challenge (توسيع البحث)
changes decrease » larger decrease (توسيع البحث), change increases (توسيع البحث)
largest decrease » larger decrease (توسيع البحث), marked decrease (توسيع البحث)
significant changes » significant challenge (توسيع البحث)
changes decrease » larger decrease (توسيع البحث), change increases (توسيع البحث)
largest decrease » larger decrease (توسيع البحث), marked decrease (توسيع البحث)
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6141
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6142
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6146
The impact of anesthesia and positioning on cerebral blood flow and pressure in patients undergoing laparoscopic surgery: an randomised observational study
منشور في 2024"…In the REV group, CCA flow decreased after the Reverse Trendelenburg position (P=0.0213). …"
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6147
Table 1_Inflammatory markers CRP and WBC as predictors of liver function impairment in multiple injury trauma patients: a repeated measures analysis.docx
منشور في 2025"…</p>Conclusion<p>CRP and white blood cell count significantly correlate with liver function changes in multiple injury patients, with marked gender-specific differences in these associations. …"
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6148
Table 1_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.docx
منشور في 2025"…</p>Methods<p>(1) Fecal samples from CRC patients (n=26) and healthy controls (n=20) were collected for metagenomic sequencing and untargeted metabolomics analysis; (2) The ability of B.o to produce NMS from orange fiber was validated in vitro; (3) A CRC mouse model was established using azoxymethane (AOM)/dextran sulfate sodium (DSS) induction, followed by evaluation of body weight, rectal bleeding, colorectal length, tumor number, and intestinal barrier function; (4) Network pharmacology, molecular docking, and western blot analysis were combined to verify the mechanism of action; (5) 16S rRNA sequencing was performed to analyze gut microbiota changes.</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…"
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6149
DataSheet1_Global burden of chronic kidney disease in adolescents and young adults, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.docx
منشور في 2024"…However, the global age-specific death rate significantly decreased from 2.96 (2.76, 3.15) to 2.86 (2.61, 3.11), and the age-specific DALY rate remained stable. …"
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6150
Table 2_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.xlsx
منشور في 2025"…</p>Methods<p>(1) Fecal samples from CRC patients (n=26) and healthy controls (n=20) were collected for metagenomic sequencing and untargeted metabolomics analysis; (2) The ability of B.o to produce NMS from orange fiber was validated in vitro; (3) A CRC mouse model was established using azoxymethane (AOM)/dextran sulfate sodium (DSS) induction, followed by evaluation of body weight, rectal bleeding, colorectal length, tumor number, and intestinal barrier function; (4) Network pharmacology, molecular docking, and western blot analysis were combined to verify the mechanism of action; (5) 16S rRNA sequencing was performed to analyze gut microbiota changes.</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…"
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6151
Table 2_Modified maxillomandibular advancement for Eastern Asian patients with moderate or severe OSA: an anatomic and aerodynamic assessment of the upper airway.xlsx
منشور في 2025"…The apnea–hypopnea index (36.05 ± 17.68 vs. 5.72 ± 4.76, p < 0.001) and the ESS (13.23 ± 8.9 vs. 6.23 ± 6.81 events/h, p < 0.05) decreased significantly, while the lowest oxygen saturation (76.54 ± 10.26% vs. 84.77 ± 6.02%, p < 0.05) improved greatly. …"
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6152
Table 1_Modified maxillomandibular advancement for Eastern Asian patients with moderate or severe OSA: an anatomic and aerodynamic assessment of the upper airway.xlsx
منشور في 2025"…The apnea–hypopnea index (36.05 ± 17.68 vs. 5.72 ± 4.76, p < 0.001) and the ESS (13.23 ± 8.9 vs. 6.23 ± 6.81 events/h, p < 0.05) decreased significantly, while the lowest oxygen saturation (76.54 ± 10.26% vs. 84.77 ± 6.02%, p < 0.05) improved greatly. …"
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6153
Data Sheet 1_The CENPN/STAT3/USP37 signaling axis promotes invasion, migration and metastasis in nasopharyngeal carcinoma.docx
منشور في 2025"…</p>Results<p>The invasion and migration capacities of nasopharyngeal carcinoma cells decreased significantly after CENPN knockdown, whereas the overexpression of CENPN significantly promoted the invasion and metastasis abilities of nasopharyngeal carcinoma cells. …"
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6154
Data Sheet 1_Global, regional, and national burden of fracture of vertebral column, 1990–2021: analysis of data from the global burden of disease study 2021.docx
منشور في 2025"…Background<p>Fractures of the vertebral column, encompassing various spinal injuries, represent a significant public health burden worldwide. These injuries can lead to long-term disability, reduced quality of life, and substantial healthcare costs.…"
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6155
Supplementary Material for: High-sensitivity Troponin I Measurement in a Large Contemporary Cohort: Implications for Clinical Care
منشور في 2025"…Laboratory data, blood pressure, and anthropomorphic measures were extracted from the electronic medical record Results: Remeasurement of hsTnI did not change risk category in 92.7% of cases. Male sex, higher HDL-C, higher Hgb A1c, decreasing eGFR, and increasing systolic blood pressure were significant predictors of increased hsTnI. …"
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6156
Table 1_Rainfall distribution variability controls surface but not belowground litter decomposition in a semi-arid shrubland.docx
منشور في 2025"…</p>Results<p>Decomposition of belowground litter was consistently higher than that of surface litter over the entire field-incubation process. Mass loss significantly decreased in surface litter but not in belowground litter due to the lower frequency and larger amount of precipitation compared to the control treatment. …"
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6157
Table 1_Effects of neutral detergent fiber levels on apparent nutrient digestibility and intestinal microbiota composition and function in forest musk deer.docx
منشور في 2025"…At the genus level (the relative abundance > 1%), the three groups did not change (p > 0.05) significantly. In the KEGG function analysis, differentially expressed genes were primarily enriched in pathways related to organismal systems and human diseases. …"
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6158
Data Sheet 1_Use of the Temperament and Character Inventory to describe the effectiveness of Gestalt therapy.docx
منشور في 2025"…</p>Results<p>Statistically significant differences between the initial and final mean scores were observed for anxiety (t = 16.46; p < 0.0001), depression (t = 11.24; p < 0.0001), and harm avoidance (t = 8.82; p < 0.0001), and global psychological distress assessed by VAS (t = 18.7; p < 0.0001) (all showing decreased scores). …"
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6159
Source Apportionment of Atmospheric Iron in Northern China Based on Three-Year Continuous Measurements
منشور في 2025"…Although PM<sub>2.5</sub> concentrations decreased significantly, the Fe component of PM<sub>2.5</sub> did not show a significant decline. …"
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6160
Data_Sheet_1_Effect of synbiotic supplementation on obesity and gut microbiota in obese adults: a double-blind randomized controlled trial.docx
منشور في 2024"…</p>Results<p>Synbiotics supplementation significantly decreased body fat percentage, waist, and serum low-density lipoprotein cholesterol (LDL-C), increased peptide YY, cholecystokinin, oxyntomodulin, GSH (glutathione peroxidase) in individuals with obesity. …"