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significant changes » significant challenge (Expand Search)
changes decrease » larger decrease (Expand Search), largest decrease (Expand Search), change increases (Expand Search)
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6541
Data Sheet 1_Protein-free domains in native and ferroptosis-driven oxidized cell membranes: a molecular dynamics study of biophysical properties and doxorubicin uptake.pdf
Published 2024“…<p>Ferroptosis is a regulated form of cell death characterized by iron-dependent lipid peroxidation of polyunsaturated fatty acids (PUFAs). Despite its significance, the precise molecular mechanisms underlying ferroptosis remain elusive, particularly concerning their impact on membrane properties. …”
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6542
Image 1_Protein-free domains in native and ferroptosis-driven oxidized cell membranes: a molecular dynamics study of biophysical properties and doxorubicin uptake.pdf
Published 2024“…<p>Ferroptosis is a regulated form of cell death characterized by iron-dependent lipid peroxidation of polyunsaturated fatty acids (PUFAs). Despite its significance, the precise molecular mechanisms underlying ferroptosis remain elusive, particularly concerning their impact on membrane properties. …”
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6543
Supporting data for "Excess mortality during the COVID-19 pandemic in Hong Kong and South Korea"
Published 2024“…Mortality from influenza and pneumonia was estimated to have a statistically significant increase in HK but a decrease in SK probability due to different coding practices. …”
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6544
Image 1_Plant-based dietary index on the Mediterranean and a vegan diet: a secondary analysis of a randomized, cross-over trial.jpeg
Published 2025“…These associations remained significant even after adjustment for changes in energy intake. …”
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6545
DataSheet1_RETRACTED: MiRNA-200b Regulates RMP7-Induced Increases in Blood-Tumor Barrier Permeability by Targeting RhoA and ROCKII.XLS
Published 2025“…Microarray analysis revealed 34 significantly deregulated miRNAs including miR-200b in the BTB as induced by RMP7 and 8 significantly up-regulated miRNAs in the BTB by RMP7. …”
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6546
Supplementary file 1_The impact of COVID-19 on thyroid function and psychological state of Graves’ disease: a one-year prospective study.jpeg
Published 2025“…At 3 months post-infection, the G3 group showed an increased FT3/FT4 ratio and decreased FT4 levels. Significant intergroup differences were observed in FT4 and TSH changes from pre-infection levels, with the G3 group having the highest anxiety and depression scores. …”
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6547
Supplementary file 2_The impact of COVID-19 on thyroid function and psychological state of Graves’ disease: a one-year prospective study.jpeg
Published 2025“…At 3 months post-infection, the G3 group showed an increased FT3/FT4 ratio and decreased FT4 levels. Significant intergroup differences were observed in FT4 and TSH changes from pre-infection levels, with the G3 group having the highest anxiety and depression scores. …”
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6548
Supplementary Material for: Treatment of plaque psoriasis with guselkumab reduces systemic inflammatory burden as measured by neutrophil/lymphocyte ratio, platelet/lymphocyte ratio...
Published 2025“…In VOYAGE I, NLR (p=0.011), PLR (p=0.015) and MLR (p=0.004) decreased significantly following 16 weeks of guselkumab treatment vs. placebo. …”
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6549
Data Sheet 1_Aleurone supplementation enhances the metabolic benefits of training in Standardbred mares: impacts on glucose-insulin dynamics and gut microbiome composition.pdf
Published 2025“…</p>Results<p>Training alone: Training significantly improved OGTT parameters by decreasing Maximum<sub>insulin</sub> (P = 0.005) and AUC<sub>insulin</sub> (P = 0.001), while increasing Time to peak<sub>insulin</sub> (P = 0.03), indicating enhanced insulin sensitivity. …”
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6550
Supplementary file 2_Wuzi-Yanzong-Wan inhibits testicular mitochondrial apoptosis in rats by downregulating TAp73-Mediated P38 MAPK-ADAM17 pathway.docx
Published 2025“…Mechanistic investigations revealed that WZYZW markedly suppressed germ cell apoptosis (flow cytometry confirmed a significant decrease in apoptotic cell proportion) and attenuated DNA damage (indicated by significantly reduced γ-H2AX (a DNA damage marker) fluorescence intensity). …”
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6551
The ADMET analysis of the selected compounds.
Published 2025“…Rg values confirmed this, with the LasI-Sulfamerazine complex being more compact (~2.00 nm) than QscR-ligand complexes (2.10–2.30 nm). PCA revealed significant conformational changes in the LasI-Sulfamerazine complex, with PC1 explaining 57.26% variance. …”
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6552
AMDET profiling parameters and shorting criteria.
Published 2025“…Rg values confirmed this, with the LasI-Sulfamerazine complex being more compact (~2.00 nm) than QscR-ligand complexes (2.10–2.30 nm). PCA revealed significant conformational changes in the LasI-Sulfamerazine complex, with PC1 explaining 57.26% variance. …”
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6553
Interactive effects of temperature and food ration on growth and mercury concentration in eastern brook trout
Published 2025“…Across a range of temperatures (16 – 24°C), Brook Trout growth rate decreased, and Hg concentration increased with temperature. …”
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6554
Data Sheet 1_Adherence to a “MediterrAsian” diet is associated with weight loss-independent improvements in liver fat and lipid profile, but not glucoregulation or inflammation: se...
Published 2025“…Analyses were conducted both without adjustments and after adjusting for weight change.</p>Results<p>Body weight, total body fat, visceral and subcutaneous adipose tissues, and liver fat decreased significantly after the intervention, in tandem with improvements in markers of glucose and lipid metabolism and inflammation. …”
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6555
Data_Sheet_1_The impact of forestry management practices on regional economic benefits and livelihood of the rural communities in Ghana: a case study of three forest reserves in th...
Published 2024“…Despite these improvements, a significant decrease in forest cover was observed in recent years. …”
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6556
Numerical Study of the Mechanical Properties and Failure Mechanisms of Shale Under Different Loading Conditions
Published 2025“…The results reveal the following key findings: (1) With an increase in the bedding angle, the uniaxial compressive strength of shale shows a U-shaped change trend, while the tensile strength gradually decreases. …”
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6557
R project including metadata update.
Published 2025“…ASAP was found to be superior to RESL due to RESL’s adherence to the concept of the DNA barcoding gap. Moreover, we found that taxonomic misassignments, inconsistencies in BIN formation, and missing metadata also contribute significantly to unreliable identifications. …”
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6558
Classes of errors and gaps in BOLD metadata.
Published 2025“…ASAP was found to be superior to RESL due to RESL’s adherence to the concept of the DNA barcoding gap. Moreover, we found that taxonomic misassignments, inconsistencies in BIN formation, and missing metadata also contribute significantly to unreliable identifications. …”
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6559
<b>IER3IP1 mutations cause neonatal diabetes due to impaired proinsulin trafficking</b>
Published 2024“…While these mutant stem cell lines differentiated normally into definitive endoderm and pancreatic progenitors, we observed that IER3IP1-KO stem cell derived-islets (SC-islets) presented a significant decrease in beta cell numbers and elevated ER stress. …”
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6560
Table2_Cuproptosis-related lncRNAs emerge as a novel signature for predicting prognosis in prostate carcinoma and functional experimental validation.docx
Published 2024“…Additionally, in vitro cellular functional experiments, we knocked down SNHG9 that is the most significantly differentially expressed ClncRNA among the three key ClncRNAs. …”