Search alternatives:
significant clusters » significant cause (Expand Search), significant changes (Expand Search), significant factors (Expand Search)
greater decrease » greatest decrease (Expand Search), greater increase (Expand Search), greater disease (Expand Search)
marked decrease » marked increase (Expand Search)
significant clusters » significant cause (Expand Search), significant changes (Expand Search), significant factors (Expand Search)
greater decrease » greatest decrease (Expand Search), greater increase (Expand Search), greater disease (Expand Search)
marked decrease » marked increase (Expand Search)
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<b>The loss of insulin-positive cell clusters precedes the decrease of islet frequency and beta cell area in type 1 diabetes</b>
Published 2025“…Insulin-positive (INS+) single cells (≤10µm), cell clusters (>10 to <35µm), small- and medium-sized islets (35-100µm and 100-200µm) were significantly lost at type 1 diabetes onset, while large INS+ islets (>200µm) were preserved. …”
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a, Anti-correlation of gene expression between <i>dmdR1</i> and its predicted regulon. Left: Pearson correlation coefficients (PCCs) between <i>dmdR1</i> and all genes with a DmdR1 position weight matrix (PWM) score greater than 15 in their regulatory region. The vertical dashed line marks the refined PWM score threshold of 22.875. The horizontal dotted lines mark PCC = ±0.43, corresponding to an adjusted <i>p</i>-value of 0.05. Right: Target genes immediately downstream of a predicted DmdR1 binding site, ordered by decreasing PWM score. Plus and minus indicate the strand of the target gene. Genes marked with an × did not have significant co-expression with <i>dmdR1</i>....
Published 2025“…Genes marked with an × did not have significant co-expression with <i>dmdR1</i>. …”