Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer In vitro حسب Najem, Sonia A.

"…Results: Our results showed that SAHA and DAC, separately, significantly decreased cell proliferation, induced apoptosis and cell cycle arrest of Caco-2 cell line. …"
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Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells حسب Castellino, R.C.

"…We previously showed that inhibition of the platelet-derived growth factor receptor (PDGFR) blocks the survival and migration of medulloblastoma cells. …"
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Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice حسب Ayman Alzu'bi (18192898)

"…These findings were found to be correlated with increased level of <u>oxidative stress, neuroinflammation,</u> and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (BDNF), which plays an essential role in modulating <u>synaptic plasticity</u> integral for promoting learning and memory in the hippocampus. Additionally, we showed that AB-FUBINACA significantly decreased the expression of NR1, an important functional subunit of glutamate/NMDA receptors and closely implicated in the development of toxic psychosis. …"

Healthcare Professionals' Attitudes Toward Patients With Mental Illness: A Cross-Sectional Study in Qatar حسب Suhaila Ghuloum (796180)

"…Stigmatizing attitudes by HCP can have adverse consequences on people with mental illness from delays in seeking help to decreased quality of care provided. Assessing such attitudes is an essential step in understanding such stigma and, if needed, developing and testing appropriate and culturally adapted interventions to reduce it.…"

A case of cat-scratch disease with unusual ophthalmic manifestations حسب Ghazi, Nicola G.

"…A 12-year-old healthy male presented with three weeks history of decreased visual acuity in the right eye. A significant history of cat exposure and elevated Bartonella titers were present. …"
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The promise of tirzepatide: A narrative review of metabolic benefits حسب Sara Sokary (17337724)

"…<p>Obesity and type 2 diabetes mellites (T2DM) are intertwined epidemics that continue to pose significant challenges to global public health. We aim to review the available evidence on the metabolic effects of tirzepatide, focusing on weight loss and maintenance of lost weight, body composition alterations, appetite regulation, glycemic control, and lipid profile modulation. …"

n-Hexadecane Fuel for a Phosphoric Acid Direct Hydrocarbon Fuel Cell حسب Zhu, YuanChen

"…We have investigated the performance of a phosphoric acid fuel cell (PAFC) reactor, with n-hexadecane, C16H34 (a model compound for diesel fuel, cetane number = 100). …"
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Whole-Genome Molecular Characterization and Typing of Staphylococcus aureus Isolated from Lebanon حسب El Hassan, Sarah

"…For the first time, we detected an untypeable SCCmec cassette harboring multiple ccr complexes or missing some of the conserved genes. …"
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Functional Connectivity Analysis under Vigilance Decrement and Enhanced Mental States حسب Hassanin, Omnia

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The Use of the Gene Expression Omnibus (GEO) Database to Study Gene Expression and Methylation Patterns in Cases of Preterm Birth and Associated Diseases حسب Tala Abuarja (17075070)

"…</p> <h3>Results</h3> <p>Of the 8 datasets, 3 displayed significant changes in expression patterns after application of the filtering criteria. …"

Prevalence of bullying and violence among adolescents in Arab Gulf countries: a systematic review حسب Amani N. Alansari (19743643)

"…Academic impacts included increased absenteeism (24–29%) and decreased performance.</p><h3 dir="ltr">Conclusion</h3><p dir="ltr">This review highlights the widespread prevalence and serious consequences of bullying among adolescents in AGC, with clear gender differences and significant impacts on mental health and academic performance. …"

Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response حسب Noura Al-Zeheimi (5177066)

"…From a panel of tested proteins and genes, we found that the levels of plasma NRP-1, placenta growth factor (PlGF) and immune cell expression of the transcription factor <i>SNAI1</i> before and after NAC were significantly different. …"

Indwelling pleural catheters in hepatic hydrothorax حسب Diab, Khalil

"…There were statistically significant decreases in both BMI and serum albumin levels following IPC placement. …"
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IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells حسب Homaidan, Fadia R.

"…Background: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased ceramide levels. …"
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A jojoba (Simmondsia chinensis) seed cake extracts express hepatoprotective activity against paracetamol-induced toxicity in rats حسب Firas Feki (17545638)

"…In addition, the histological analysis of liver tissues proved significant injury and hepatocellular necrosis. WE and NE extract showed a relatively high in vitro radical scavenging (ORAC) and averting activities (HORAC) with a polyphenol content of 3.6 % and 2.9 %, respectively. …"

The effect of type and combination of fertilizers on eukaryotic microbiome of date palm rhizosphere حسب Sara H. Al-Hadidi (17821196)

"…However, a high concentration of biofertilizer combined with a low concentration of chemical fertilizers enhanced the eukaryotic diversity within the samples. We conclude that cultivar type (biotic factor), type of fertilizer, and dosage (abiotic factor) play significant roles in determining the microbiome diversity of the rhizosphere. …"

PGAP3 Associated with Hyperphosphatasia with Mental Retardation Plays a Novel Role in Brain Morphogenesis and Neuronal Wiring at Early Development حسب Sahar I. Da’as (9631717)

"…<p dir="ltr">Recessive mutations in Post-GPI attachment to proteins 3 (PGAP3) cause the rare neurological disorder hyperphosphatasia with mental retardation syndrome 4 type (HPMRS4). Here, we report a novel homozygous nonsense mutation in PGAP3 (c.265C>T-p.Gln89*), in a 3-year-old boy with unique novel clinical features. …"

Optimum sizing of steam turbines for concentrated solar power plants حسب Poullikkas, Andreas

"…For capacity sizes of 10kWe up to 50MWe, the steam turbine efficiency increases and the steam turbine expected specific capital cost of the power block decreases at a high rate, whereas for larger sizes they remain almost constant. …"
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Direct Oral Anticoagulants Compared to Warfarin in Patients with Intermediate‐ to High‐Risk Pulmonary Embolism: A Systematic Review and Meta‐Analysis حسب Mohamed Nabil Elshafei (9960500)

"…Direct oral anticoagulants were associated with comparable recurrence and mortality rates versus warfarin (odds ratio [OR] 0.72, 95% confidence interval [CI] 0.15–3.43) and (OR 0.57, 95% CI 0.16–2.01), respectively. There was no significant difference in the safety outcomes (major and minor bleeding events), with a trend towards a decreased risk among direct oral anticoagulant treated cohorts (OR 0.3, 95% CI 0.08–1.1) and (OR 0.64, 95% CI 0.24–1.7), respectively.…"

Prevention of carcinogen-induced mouse skin papilloma by Daucus carota (wild carrot) aqueous extract حسب Mroueh, M.

"…Intraperitoneal treatment decreased hyperplasia and dermal infiltration with an increase in the level of hyperkeratosis. …"
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